Significant Immunohistochemical Expression of Human Chorionic Gonadotropin in High-Grade Osteosarcoma is Rare, but May Be Associated with Clinically Elevated Serum Levels

2014 ◽  
Vol 17 (4) ◽  
pp. 278-285 ◽  
Author(s):  
Anna F. Lee ◽  
Bruce R. Pawel ◽  
Lisa M. Sullivan
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Elevated Serum ◽  
Serum Levels ◽  
High Grade ◽  
Immunohistochemical Expression ◽  
High Grade Osteosarcoma

scholarly journals Don’t cancel the surgery just yet! A case report of positive preoperative pregnancy test due to a soft tissue sarcoma production of ectopic beta human chorionic gonadotropin

Rare Tumors ◽  
2018 ◽  
Vol 10 ◽  
pp. 203636131878972
Author(s):  
Alan Todd Blank ◽  
Mazdak Khalighi ◽  
R Lor Randall ◽  
Kevin B Jones
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Immunohistochemical Staining ◽  
Elevated Serum ◽  
Soft Tissue Sarcomas ◽  
High Grade ◽  
Beta Human Chorionic Gonadotropin ◽  
Rare Group

Soft tissue sarcomas are a rare group of mesenchymal malignancies which can range from low to high grade. These tumors have different clinical, radiographic, and histopathological characteristics. Beta human chorionic gonadotropin is a naturally secreted hormone by placental syncytiotrophoblast cells during pregnancy. On very rare occasions, sarcomas can develop the ability to ectopically produce human chorionic gonadotropin. Very few cases exist in the literature of soft tissue sarcomas expressing this hormone. We report the case of a 55-year-old female who presented with a posterior thigh soft tissue sarcoma who on the day of surgical resection was found to have an unusually elevated serum human chorionic gonadotropin. Positive immunohistochemical staining of the resected mass confirmed the sarcoma as the source of the beta human chorionic gonadotropin.

Human chorionic gonadotropin (HCG) as a biomarker in sarcoma: A systematic review.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e22503-e22503
Author(s):  
Martin W. Schoen ◽  
Ahmad Al-Taee ◽  
Bassel Jallad
Keyword(s):  
Systematic Review ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Low Cost ◽  
Elevated Serum ◽  
Germ Cell Tumors ◽  
Response To Therapy ◽  
Response To Treatment ◽  
High Grade ◽  
Poorly Differentiated

e22503 Background: Human chorionic gonadotropin (HCG) has been reported in soft tissue sarcoma and osteosarcoma. In some patients, the ectopic production of HCG can lead to delays in diagnosis due to concern for pregnancy or germ cell tumors. Methods: We performed a systematic review of the scientific literature in English using PubMed to categorize cases of sarcoma search terms were HCG, sarcoma, human chorionic gonadotropin and osteosarcoma. Cases of sarcoma associated with HCG production were identified and further categorized by type and grade of tumor. Initial HCG, Peak HCG, response to therapy and case outcome were collected when available. We also included a case seen at our institution of osteosarcoma with ectopic HCG production. Results: We identified 21 manuscripts and 23 cases of patients with both sarcoma and elevated serum HCG. 10/23 patients were male (43%).The most frequent type of sarcoma was osteosarcoma with 9/23 (39%) of cases, leiomyosarcoma was identified in 7/23 (30%) and liposarcoma in 3/23 (13%) of cases. When described, all tumors were high grade or poorly differentiated. 20/23 tumors (87%) had HCG expression of the tumor by immunohistochemistry. Mean initial HCG was 3607 with a peak value of 6188. In 19 cases, HCG was used to monitor disease after treatment and 14/19 (74%) responded with a decrease in HCG after treatment. Of responders, 3 patients were considered cured and 2 were put into remission, while none of the patients without response survived. Overall, outcomes were poor with 16/23 (70%) deaths within one year. Conclusions: Sarcomas that secrete HCG tend to be high grade, poorly differentiated and appear to portend a poor prognosis. When expressed, HCG can be used as a marker of disease and response to therapy. Oncologists should consider checking HCG as a potentially low-cost marker of prognosis and response to treatment in patients with sarcoma. [Table: see text]

Production of human chorionic gonadotropin—β subunit associated with an osteolytic meningioma

2002 ◽  
Vol 97 (1) ◽  
pp. 197-199 ◽  
Author(s):  
Cheng-shyuan Rau ◽  
Jui-wei Lin ◽  
Cheng-loong Liang ◽  
Tao-chen Lee ◽  
Han-jung Chen ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Elevated Serum ◽  
Immunohistochemical Analysis ◽  
Serum Levels ◽  
Β Subunit ◽  
Content Type ◽  
First Case ◽  
Β Hcg ◽  
Microscopy Examination

✓ An osteolytic meningioma in a 36-year-old woman was accompanied by elevated serum levels of human chorionic gonadotropin—β subunit (β-HCG), which returned to normal after removal of the tumor. Light microscopy examination demonstrated a transitional meningioma. Immunohistochemical analysis revealed that the tumor cells had a positive reaction for β-HCG. This case illustrates the possibility that meningioma may be associated with clinically detectable secretion of β-HCG. To the authors' knowledge, this is the first case in which meningioma has been shown to secrete β-HCG. The authors believe that meningioma should be considered in the differential diagnosis of choriocarcinoma, embryonal cell tumor, germinoma, and metastatic ovarian tumor associated with elevated levels of β-HCG.

scholarly journals The Value of Hysteroscopy in Women with Persistently Elevated Post-Evacuation Serum Human Chorionic Gonadotropin (hCG) Level Following Evacuation of Molar Disease

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A H Bakhat ◽  
S T Fayed ◽  
A M Ibrahim ◽  
A H Naguib ◽  
M A Faris
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Gynecologic Oncology ◽  
Hydatidiform Mole ◽  
Elevated Serum ◽  
Serum Levels ◽  
Gestational Trophoblastic Disease ◽  
Invasive Disease ◽  
Maternity Hospital ◽  
Postoperative Serum

Abstract Background and rational Gestational trophoblastic disease (GTD) is a spectrum of trophoblastic diseases that encompass the hydatidiform mole (both complete and partial), as well as the potentially-malignant and malignant forms: invasive mole, choriocarcinoma and placental site trophoblastic tumor. Gestational trophoblastic neoplasia (GTN) refers to persistent elevation of serum levels of human chorionic gonadotropin (hCG). The subsequentmanagement of GTD after evacuation of the uterus relies on serial surveillance of serum hCG levels. When serum hCG levels plateau or rise, chemotherapy should promptly be initiated. Patients and Methods This study for accuracy of a diagnostic test. The current study was conducted at Gynecologic Oncology Unit and Early Cancer Detection Unit at Ain Shams University Maternity Hospital during the period between January 2016 and June 2018. Results In the present study, the case who had a vascular mass, the patient was 44 years old and she was para 4, so board decision was for TAH. Postoperative serum hCG surveillance for this case showed adequately declining levels. She, accordingly, did not receive chemotherapy. For the 19/44 (43.2%) cases who had a hysteroscopic finding of ‘an empty cavity’ were diagnosed as persistent GTN and received chemotherapy according to the protocol. The remaining 25/44 (56.8%) cases, who had a hysteroscopic finding of ‘remnants’, underwent re-evacuation. Postoperative serum hCG surveillance showed persistently elevated levels in 9/44 (20.5%) cases, who, therefore, received chemotherapy according to the protocol; and adequately declining levels in 16/44 (36.4%) cases, who, accordingly, did not receive chemotherapy. Conclusion The hysteroscopy significantly reduced the risk of chemotherapy in women with hydatidiform mole and have persistent post-evacuation elevated serum hCG level and sonographic criteria of invasive disease.

Elevated Serum Levels of Interleukin-6, Interleukin-1β and Human Chorionic Gonadotropin in Pre-eclampsia

2011 ◽  
Vol 66 (6) ◽  
pp. 468-475 ◽  
Author(s):  
Michail Kalinderis ◽  
Alexis Papanikolaou ◽  
Kallirhoe Kalinderi ◽  
Elizabeth Ioannidou ◽  
Charalambos Giannoulis ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Interleukin 6 ◽  
Elevated Serum ◽  
Serum Levels ◽  
Interleukin 1Β

Immunohistochemical expression of ?-human chorionic gonadotropin in colorectal carcinoma

Surgery Today ◽  
1996 ◽  
Vol 26 (12) ◽  
pp. 966-970 ◽  
Author(s):  
Akinori Kido ◽  
Masaki Mori ◽  
Yosuke Adachi ◽  
Hirofumi Yukaya ◽  
Teruyoshi Ishida ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Immunohistochemical Expression
Sign in / Sign up

Export Citation Format

Share Document