Potential short interfering RNAs (siRNA) modulating gene expression have emerged as a novel therapeutic
arsenal against a wide range of maladies and disorders containing cancer, viral infections, bacterial ailments
and metabolic snags at the molecular level. Nanogel, in the current medicinal era, displayed a comprehensive
range of significant drug delivery prospects. Biodegradation, swelling and de-swelling tendency, pHsensitive
drug release and thermo-sensitivity are some of the renowned associated benefits of nanogel drug delivery
system. Global researches have also showed that nanogel system significantly targets and delivers the biomolecules
including DNAs, siRNA, protein, peptides and other biologically active molecules. Biomolecules
delivery via nanogel system explored a wide range of pharmaceutical, biomedical engineering and agro-medicinal
application. The siRNAs and DNAs delivery plays a vivacious role by addressing the hitches allied with chronic
and contemporary therapeutic like generic possession and low constancy. They also incite release kinetics approach
from slow-release while mingling to rapid release at the targets will be beneficial as interference RNAs
delivery carriers. Therefore, in this research, we focused on the latest improvements in the delivery of siRNA
loaded nanogels by enhancing the absorption, stability, sensitivity and combating the hindrances in cellular trafficking
and release process.
