Clinical outcomes in adults' subjects with aphthous stomatitis treated with an oral hyaluronic acid-based medical device

Background: Although platelet-rich plasma (PRP) has potential as a regenerative treatment for knee osteoarthritis, its efficacy varies. Compositional differences among types of PRP could affect clinical outcomes, but the biological characterization of PRP is lacking. Purpose: To assess the efficacy of intra-articular PRP injection in knee osteoarthritis as compared with hyaluronic acid (HA) injection and to determine whether the clinical efficacy of PRP is associated with its biological characteristics. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A total of 110 patients with symptomatic knee osteoarthritis received a single injection of leukocyte-rich PRP (1 commercial kit) or HA. Clinical data were assessed at baseline and at 6 weeks and 3 and 6 months after injection. The primary endpoint was an improvement in the International Knee Documentation Committee (IKDC) subjective score at 6 months, and the secondary endpoints were improvements in scores based on the Patient Global Assessment, the visual analog scale (VAS) for pain, the Western Ontario and McMaster Universities Osteoarthritis Index, and the Samsung Medical Center patellofemoral score. Cell counts and concentrations of growth factors and cytokines in the injected PRP were assessed to determine their association with clinical outcomes. Results: PRP showed significantly improvement in IKDC subjective scores at 6 months (11.5 in the PRP group vs 6.3 in the HA group; P = .029). There were no significant differences between groups in other clinical outcomes. The Patient Global Assessment score at 6 months was better in the PRP group ( P = .035). The proportion of patients who scored above the minimal clinically important difference (MCID) for VAS at 6 months was significantly higher in the PRP group ( P = .044). Within the PRP group, the concentrations of platelet-derived growth factors were high in patients with a score above the MCID for VAS at 6 months. The incidence of adverse events did not differ between the groups ( P > .05). Conclusion: PRP had better clinical efficacy than HA. High concentrations of growth factors were observed in patients who scored above the MCID for clinical outcomes in the PRP group. These findings indicate that concentration of growth factors needs to be taken into consideration for future investigations of PRP in knee osteoarthritis. Registration: NCT02211521 (ClinicalTrials.gov identifier).

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Commentary: Novel Hyaluronic Acid Dermal Filler: Dermal Gel Extra Physical Properties and Clinical Outcomes

Dermatologic Surgery ◽

10.1111/j.1524-4725.2010.01781.x ◽

2010 ◽

Vol 36 (Suppl 3) ◽

pp. 1842

Author(s):

JEAN CARRUTHERS

Keyword(s):

Hyaluronic Acid ◽

Physical Properties ◽

Clinical Outcomes ◽

Dermal Filler

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Long-Term Clinical Outcomes and Parental Satisfaction After Dextranomer/Hyaluronic Acid (Dx/HA) Injection for Primary Vesicoureteral Reflux

Frontiers in Pediatrics ◽

10.3389/fped.2019.00392 ◽

2019 ◽

Vol 7 ◽

Cited By ~ 1

Author(s):

Michelle Lightfoot ◽

Aylin N. Bilgutay ◽

Noah Tollin ◽

Scott Eisenberg ◽

Jake Weiser ◽

...

Keyword(s):

Hyaluronic Acid ◽

Clinical Outcomes ◽

Vesicoureteral Reflux ◽

Parental Satisfaction ◽

Primary Vesicoureteral Reflux

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Corrigendum

The American Journal of Sports Medicine ◽

10.1177/0363546517700110 ◽

2017 ◽

Vol 45 (5) ◽

pp. NP10-NP10

Keyword(s):

Randomized Controlled Trial ◽

Hyaluronic Acid ◽

Knee Osteoarthritis ◽

Clinical Outcomes ◽

Platelet Rich Plasma ◽

Controlled Trial ◽

Double Blind ◽

Randomized Controlled ◽

Acid Versus

Cole BJ, Karas V, Hussey K, Merkow DB, Pilz K, Fortier LA. Hyaluronic acid versus platelet-rich plasma: a prospective, double-blind randomized controlled trial comparing clinical outcomes and effects on intra-articular biology for the treatment of knee osteoarthritis. Am J Sports Med. 2017;45(2):339-346. (Original DOI: 10.1177/0363546516665809 )

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Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment

Nanomaterials ◽

10.3390/nano10040628 ◽

2020 ◽

Vol 10 (4) ◽

pp. 628 ◽

Cited By ~ 3

Author(s):

João P. F. Carvalho ◽

Ana C. Q. Silva ◽

Verónica Bastos ◽

Helena Oliveira ◽

Ricardo J. B. Pinto ◽

...

Keyword(s):

Hyaluronic Acid ◽

In Vitro Release ◽

Three Dimensional ◽

Human Keratinocytes ◽

Controlled Drug Release ◽

Dynamic Mechanical Properties ◽

Aphthous Stomatitis ◽

Release Mechanism ◽

Porous Network

Nanostructured patches composed of bacterial nanocellulose (BNC), hyaluronic acid (HA) and diclofenac (DCF) were developed, envisioning the treatment of aphthous stomatitis. Freestanding patches were prepared via diffusion of aqueous solutions of HA and DCF, with different concentrations of DCF, into the wet BNC three-dimensional porous network. The resultant dual polysaccharides-based patches with a nanostructured morphology present thermal stability up to 200 °C, as well as good dynamic mechanical properties, with a storage modulus higher than 1.0 GPa. In addition, the patches are non-cytotoxic to human keratinocytes (HaCaT cells), with a cell viability of almost 100% after 24 h. The in vitro release profile of DCF from the patches was evaluated in simulated saliva, and the data refer to a diffusion- and swelling-controlled drug-release mechanism. The attained results hint at the possibility of using these dual polysaccharides-based oral mucosal patches to target aphthous stomatitis.

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