Simulation-based Integrated Design and Control with Embedded Mixed-Integer MPC using Constrained Bayesian Optimization

Author(s):  
Naitik A. Choksi ◽  
Joel A. Paulson
Author(s):  
Takeshi D. Itoh ◽  
Takaaki Horinouchi ◽  
Hiroki Uchida ◽  
Koichi Takahashi ◽  
Haruka Ozaki

In automated laboratories consisting of multiple different types of instruments, scheduling algorithms are useful for determining the optimal allocations of instruments to minimize the time required to complete experimental procedures. However, previous studies on scheduling algorithms for laboratory automation have not emphasized the time constraints by mutual boundaries (TCMBs) among operations, which is important in procedures involving live cells or unstable biomolecules. Here, we define the “scheduling for laboratory automation in biology” (S-LAB) problem as a scheduling problem for automated laboratories in which operations with TCMBs are performed by multiple different instruments. We formulate an S-LAB problem as a mixed-integer programming (MIP) problem and propose a scheduling method using the branch-and-bound algorithm. Simulations show that our method can find the optimal schedules of S-LAB problems that minimize overall execution time while satisfying the TCMBs. Furthermore, we propose the use of our scheduling method for the simulation-based design of job definitions and laboratory configurations.


Author(s):  
Hui Li ◽  
Linxuan Zhang ◽  
Tianyuan Xiao ◽  
Jietao Dong

This paper introduces a CPS application for intelligent aeroplane assembly. At first, the CPS structure is presented, which acquires the characteristics of general CPS and enables "simulation-based planning and control" to achieve high level intelligent assembly. Then the paper puts forward data fusion estimation algorithm under synchronous and asynchronous sampling, respectively. The experiment shows that global optimal distributed fusion estimation under synchronized sampling proves to be closer to the actual value compared with ordinary weighted estimation, and multi-scale distributed fusion estimation algorithm of wavelet under asynchronous sampling does not need time registration, it can also directly link to data, and the error is smaller. This paper presents hybrid control strategy under the circumstance of joint action of the inner and outer loop to address the problems caused by the less controllable feature of the parallel mechanism when undertaking online process simulation and control. A robust adaptive sliding mode controller is designed based on disturbance observer to restrain inner interference and maintain robustness. At the same time, an outer collaborative trajectory planning is also designed. All the experiment results show the feasibility of above proposed methods.


Sign in / Sign up

Export Citation Format

Share Document