scholarly journals The Diagnostic Utility of Calretinin in Deep Fibromatosis when Dilemma of Spindle Cell Mimic Lesions are Considered: An Immunohistochemical Study

2020 ◽  
Vol 6 (2) ◽  
Author(s):  
El-Din Somaia Ahmed Saad ◽  
Shakweer Marwa Mosaad
Keyword(s):  
Spindle Cell ◽  
Immunohistochemical Study ◽  
Diagnostic Utility ◽  
Deep Fibromatosis

Congenital Supratentorial and Infratentorial Peripheral Neurogenic Tumor: A Clinical, Ultrastructural, and Immunohistochemical Study

Neurosurgery ◽  
1986 ◽  
Vol 19 (3) ◽  
pp. 426-433 ◽  
Author(s):  
David S. Moss ◽  
Stephen J. Haines ◽  
Arnold S. Leonard ◽  
Louis P. Dehner
Keyword(s):  
Spindle Cell ◽  
Immunohistochemical Study ◽  
Operative Procedure ◽  
Cranial Nerves ◽  
Vascular Differentiation ◽  
Spindle Cell Neoplasm ◽  
Nerve Sheath ◽  
Neuroectodermal Tumors ◽  
The Central Nervous System ◽  
Supratentorial Mass

Abstract Congenital neoplasms of the central nervous system are extremely rare, although they have been well documented since the earliest reports from the mid-19th century. Medulloblastoma, other primitive neuroectodermal tumors, and various types of gliomas have comprised the majority of cases. This report describes a highly unusual infratentorial and supratentorial tumor presenting as a scalp mass in a neonate who experienced in utero distress. The supratentorial mass extended through a defect in the skull to the parietooccipital lobe, and the infratentorial aspect involved the 9th and 10th cranial nerves in the region of the cerebellopontine angle. A complex spindle cell neoplasm incorporating peripheral nerve sheath and vascular characteristics was further characterized by electron microscopy and immunohistochemistry. Based upon these studies, the tumor was interpreted as a congenital schwannoma with divergent vascular differentiation. The child has been tumor-free for approximately 2 years after the initial operative procedure.

Pediatric Angiosarcoma of Soft Tissue: A Rare Clinicopathologic Entity

2010 ◽  
Vol 134 (3) ◽  
pp. 481-485 ◽  
Author(s):  
Lobna Ayadi ◽  
Abdelmajid Khabir
Keyword(s):  
Spindle Cell ◽  
Immunohistochemical Study ◽  
Kaposi Sarcoma ◽  
Neck Region ◽  
Epithelioid Hemangioendothelioma ◽  
Vascular Tumors ◽  
Clinical Settings ◽  
Vascular Differentiation ◽  
Head And Neck Region ◽  
Poorly Differentiated

Abstract Angiosarcomas are rare tumors that predominantly affect adults and elderly patients. Although angiosarcomas are well described in a variety of clinical settings, they have been poorly studied in children and little is known about their biology, natural history, or optimal treatment. Childhood angiosarcomas are exceedingly rare. The head and neck region and mediastinum seem to be the preferred locations. Most tumors are high-grade tumors. Vasoformative architecture is not always obvious on light microscopy requiring the benefit of immunohistochemical study. The differential diagnosis includes Kaposi sarcoma, epithelioid hemangioendothelioma, hemangiopericytoma, and spindle cell hemangioendothelioma whose prognosis is different. Complete resection is required for patients with localized tumors. Malignant vascular tumors are rare in children in the first 2 decades of life and when they do occur they seem to be more aggressive than in adults. Pathologic diagnosis is difficult particularly in poorly differentiated angiosarcomas requiring immunohistochemical study to confirm vascular differentiation.

An immunohistochemical study of metaplastic spindle cell carcinoma, phyllodes tumor and fibromatosis of the breast

2003 ◽  
Vol 34 (10) ◽  
pp. 1009-1015 ◽  
Author(s):  
Barbara Dunne ◽  
Andrew H.S Lee ◽  
Sarah E Pinder ◽  
Jane A Bell ◽  
Ian O Ellis
Keyword(s):  
Cell Carcinoma ◽  
Spindle Cell ◽  
Immunohistochemical Study ◽  
Phyllodes Tumor ◽  
Spindle Cell Carcinoma

Thymic carcinosarcoma associated with a spindle cell thymoma: an immunohistochemical study

1992 ◽  
Vol 21 (3) ◽  
pp. 263-268 ◽  
Author(s):  
D.SUAREZ VILELA ◽  
J.S.SALAS VALIEN ◽  
M.A.GONZALEZ MORAN ◽  
F.IZQUIERDO GARCIA ◽  
J.R.RIERA VELASCO
Keyword(s):  
Spindle Cell ◽  
Immunohistochemical Study

Expression of WT-1, Bcl-2, and CD34 by Primary Renal Spindle Cell Tumors in Children

2004 ◽  
Vol 7 (6) ◽  
pp. 577-582 ◽  
Author(s):  
Lei Shao ◽  
D. Ashley Hill ◽  
Elizabeth J. Perlman
Keyword(s):  
Spindle Cell ◽  
Clear Cell ◽  
Immunohistochemical Study ◽  
Wilms Tumor ◽  
Expression Profiles ◽  
Potential Utility ◽  
Mesoblastic Nephroma ◽  
Immunohistochemical Markers ◽  
Synovial Sarcomas ◽  
Spindle Cell Tumors

The confident diagnosis of renal spindle cell tumors in children is often difficult. An immunohistochemical study of WT-1, Bcl-2, and CD34 was performed to determine their expression profiles and to assess the potential utility of these immunohistochemical markers in the differential diagnosis of 36 cases of renal spindle cell tumors of childhood. The cases included 11 stromal predominant Wilms tumors, 12 cellular mesoblastic nephromas, 9 clear cell sarcomas of the kidney (CCSK), and 4 monophasic synovial sarcomas. WT-1 was uniformly positive in primitive undifferentiated stromal Wilms tumors (6 of 6) and negative in the differentiating and differentiated stromal elements of Wilms tumors (0 of 5). WT-1 was also negative in cellular mesoblastic nephromas (0 of 12), CCSKs (0 of 12), and synovial sarcomas (0 of 4). Bcl-2 was expressed in all stromal Wilms tumors (11 of 11), all synovial sarcomas (4 of 4), some CCSKs (4 of 9), and none of the cellular mesoblastic nephromas (0 of 12). Although CD34 was absent in the tumor cells of all the tumors studied (0 of 36), CD34 immunohistochemistry nicely demonstrated the evenly distributed septal capillaries characteristic of CCSK in all 9 cases of this tumor. We conclude that a combination of WT-1 and Bcl-2 immunohistochemistry may aid in the distinction of stromal Wilms tumor, monophasic synovial sarcoma, cellular mesoblastic nephroma, and CCSK.

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