scholarly journals Assessment of the Immune Effect and Safety of Cell Culture-Derived Influenza Vaccine from Egg-Derived by Meta Analysis

2020 ◽  
Vol 5 (10) ◽  
pp. 456-459
Author(s):  
Xingliang Geng ◽  
Ze Liu ◽  
Guoyang Liao
Keyword(s):  
Cell Culture ◽  
Clinical Trials ◽  
Randomised Controlled Trial ◽  
Influenza Vaccine ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Human Beings ◽  
Immune Effect ◽  
Randomised Controlled

Objective: The study was to evaluate the immune effect and safety difference of cell culture-derived influenza vaccine from egg-derived by meta analysis; Methods: It selected the article about clinical trials through medline, embase, cochrane library, FEBM, clinicaltrials.gov, WHO, and International Standard Randomised Controlled Trial Number Registry. There was no language restrictions (update to Apr 25, 2016). The threshold should contain cell culture-derived or egg-derived influenza vaccine for human beings; Result: It showed enough immune effect and accepted safety by using cell culture-derived influenza vaccine, compared with egg-derived influenza vaccine; Conclusion: The cell culture-derived influenza vaccine could be used for human after clinical trials, not differ from egg-derived.

scholarly journals Systematic Review and Meta-Analysis of the Use of Hyaluronic Acid Injections to Restore Interproximal Papillae

2021 ◽  
Author(s):  
Arturo Sanchez-Perez ◽  
Tania Rosa-Vela ◽  
Bibiana Mateos-Moreno ◽  
Alfonso Jornet-Garcia ◽  
Carlos Navarro-Cuellar
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Hyaluronic Acid ◽  
Randomised Controlled Trial ◽  
Social Relationships ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Black Triangle ◽  
Interdental Papilla ◽  
Randomised Controlled

The absence of interdental papillae leads to the appearance of black triangle. For most patients, the appearance of these triangles is an important reason for concern and affects their social relationships. Multiple reconstruction techniques have been developed with different degrees of success and predictability. The main aim of this study was to evaluate the efficiency of hyaluronic acid (HA) injected into interproximal papillae six months after injection and to perform a systematic review and meta-analysis. After a systematic review, five articles were selected: a clinical randomised controlled trial and four clinical trials. In total, eighty-five patients with a deficiency in upper papillae in the front of the maxilla and jaw were included in the study. The height variable was evaluated (mm) six months after HA injection. In total, one hundred and four interproximal papillae were studied. Three articles showed an important difference in favour of intervention. The total result regarding in the injection of AH was favourable with an approximate average filling of 0.7 mm in the height of the interdental papilla. The injection of HA for the reconstruction of deficient papillae in the region of the upper and lower maxilla was a possible option treatment strategy.

Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial

The Lancet ◽  
2007 ◽  
Vol 370 (9587) ◽  
pp. 580-589 ◽  
Author(s):  
Isabel Leroux-Roels ◽  
Astrid Borkowski ◽  
Thomas Vanwolleghem ◽  
Mamadou Dramé ◽  
Frédéric Clement ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Influenza Vaccine ◽  
Pandemic Influenza ◽  
Controlled Trial ◽  
Randomised Controlled

scholarly journals Update on the EFFECTS study of fluoxetine for stroke recovery: a randomised controlled trial in Sweden

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Erik Lundström ◽  
◽  
Eva Isaksson ◽  
Per Näsman ◽  
Per Wester ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Severe Heart Failure ◽  
Stroke Recovery ◽  
Neurological Deficits ◽  
Exclusion Criterion ◽  
Link Type ◽  
Parallel Group ◽  
Randomised Controlled

Abstract Studies have suggested that fluoxetine might improve neurological recovery after stroke, but the results remain inconclusive. The EFFECTS (Efficacy oF Fluoxetine – a randomisEd Controlled Trial in Stroke) reached its recruitment target of 1500 patients in June 2019. The purpose of this article is to present all amendments to the protocol and describe how we formed the EFFECTS trial collaboration in Sweden. Methods In this investigator-led, multicentre, parallel-group, randomised, placebo-controlled trial, we enrolled non-depressed stroke patients aged 18 years or older between 2 and 15 days after stroke onset. The patients had a clinical diagnosis of stroke (ischaemic or intracerebral haemorrhage) with persisting focal neurological deficits. Patients were randomised to fluoxetine 20 mg or matching placebo capsules once daily for 6 months. Results Seven amendments were made and included clarification of drug interaction between fluoxetine and metoprolol and the use of metoprolol for severe heart failure as an exclusion criterion, inclusion of data from central Swedish registries and the Swedish Stroke Register, changes in informed consent from patients, and clarification of design of some sub-studies. EFFECTS recruited 1500 patients at 35 centres in Sweden between 20 October 2014 and 28 June 2019. We plan to unblind the data in January 2020 and report the primary outcome in May 2020. Conclusion EFFECTS will provide data on the safety and efficacy of 6 months of treatment with fluoxetine after stroke in a Swedish health system setting. The data from EFFECTS will also contribute to an individual patient data meta-analysis. Trial registration EudraCT 2011-006130-16. Registered on 8 August 2014. ISRCTN, ISRCTN13020412. Registered on 19 December 2014. ClinicalTrials.gov: NCT02683213. Retrospectively registered on 2 February 2016.

scholarly journals Methods and efficacy of social support interventions in preventing suicide: a systematic review and meta-analysis

2021 ◽  
pp. ebmental-2021-300318
Author(s):  
Xiaofei Hou ◽  
Jiali Wang ◽  
Jing Guo ◽  
Xinxu Zhang ◽  
Jiahai Liu ◽  
...  
Keyword(s):  
Social Support ◽  
Clinical Trials ◽  
Suicide Attempts ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Intervention Group ◽  
Inclusion Criteria ◽  
Support Providers ◽  
Study Selection ◽  
Randomised Controlled

QuestionSuicide is a global public and mental health problem. The effectiveness of social support interventions has not been widely demonstrated in the prevention of suicide. We aimed to describe the methods of social support interventions in preventing suicide and examine the efficacy of them.Study selection and analysisWe searched literature databases and conducted clinical trials. The inclusion criteria for the summary of intervention methods were as follows: (1) studies aimed at preventing suicide through method(s) that directly provide social support; (2) use of one or more method(s) to directly provide social support. The additional inclusion criteria for meta-analysis on the efficacy of these interventions included: (1) suicide, suicide attempt or social support-related outcome was measured; (2) randomised controlled trial design and (3) using social support intervention as the main/only method.FindingsIn total, 22 656 records and 185 clinical trials were identified. We reviewed 77 studies in terms of intervention methods, settings, support providers and support recipients. There was a total of 18 799 person-years among the ten studies measuring suicide. The number of suicides was significantly reduced in the intervention group (risk ratio (RR)=0.48, 95% CI 0.27 to 0.85). In 14 studies with a total of 14 469 person-years, there was no significant reduction of suicide attempts in the overall pooled RR of 0.88 (95% CI 0.73 to 1.07).ConclusionsSocial support interventions were recommended as a suicide prevention strategy for those with elevated suicide risk.

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