scholarly journals Results of routine first trimester screening tests and following invasive procedures during pregnancy

2015 ◽  
Vol 23 (1) ◽  
pp. 50-55
Author(s):  
Rahime Nida Ergin ◽  
Murat Yayla
Keyword(s):  
First Trimester ◽  
Screening Tests ◽  
First Trimester Screening ◽  
Invasive Procedures ◽  
Trimester Screening

scholarly journals Reducing the Risk of Preterm Preeclampsia: Comparison of Two First Trimester Screening and Treatment Strategies in a Single Centre in Switzerland

2021 ◽  
Author(s):  
Sofia Amylidi-Mohr ◽  
Jakub Kubias ◽  
Stefanie Neumann ◽  
Daniel Surbek ◽  
Lorenz Risch ◽  
...  
Keyword(s):  
At Risk ◽  
Treatment Strategies ◽  
First Trimester ◽  
Screening Tests ◽  
First Trimester Screening ◽  
Single Centre ◽  
Positive Rate ◽  
Trimester Screening ◽  
Different Populations ◽  
Screening Approaches

Abstract Introduction First trimester screening for preeclampsia (PE) is based on the combined risks model. Recent trials demonstrate that variations in multiple of the medians (MoMs) of the screening markers influence the performance of the algorithm in different populations. The aim of this study is to compare the performance of the algorithm in two cohorts with different prevention strategies. Material and Methods All first trimester screening tests performed between January 2014 and April 2020 were included. Up to June 2017 pregnancies with a risk > 1 : 200 for early-onset PE (eoPE) were considered at risk and received 100 mg of aspirin (strategy A). From July 2017 onwards, pregnancies with a risk > 1 : 100 for preterm PE (pPE) received 150 mg of aspirin (strategy B). We compared the screen positive rates (SPR) and incidence of PE between the two screening approaches. Statistical analysis were performed with Graphpad 8.0. Results 3552 pregnancies were included; 1577 pregnancies were screened according to strategy A, 1975 pregnancies according to strategy B. The screen positive rate (SPR) for strategy A and B was 8.9 and 16.9% respectively (p < 0.0001) while the incidence of PE was 1.41 and 1.84% respectively (p = ns). Conclusion With a SPR of less than 10% we achieved a remarkably low rate of PE in our population, no further reduction in PE could be achieved by an increase in the SPR and LDA-prescription during the second screening period. The cut-off to define a pregnancy at risk for PE should be tailored to keep the SPR below 10% to avoid unnecessary treatment with aspirin.

scholarly journals The impact of prenatal screening tests on prenatal diagnosis in Taiwan from 2006 to 2019: a regional cohort study

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Ching Hua Hsiao ◽  
Ching Hsuan Chen ◽  
Po Jen Cheng ◽  
Steven W. Shaw ◽  
Woei Chyn Chu ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Prenatal Screening ◽  
Diagnostic Testing ◽  
First Trimester ◽  
Screening Tests ◽  
Screening Methods ◽  
Second Trimester ◽  
Invasive Procedures ◽  
Trimester Screening ◽  
The Impact

Abstract Background The purpose of this study is to evaluate the impact of prenatal screening tests on prenatal diagnosis in Taiwan’s 14 years from 2006 to 2019. Methods The prenatal screening methods evolved from the second-trimester serum screening to combined first-trimester screening (cFTS) and then followed by the non-invasive cell-free DNA prenatal test (NIPT). The data used by the Department of Statistics, the Ministry of Health and Welfare and Department of Household Registration, Ministry of the Interior public website. Results This regional registry-based cohort retrospective study examined a total of 2,775,792 births from January 2006 to December 2019. The proportion of advanced maternal age (AMA) pregnancies increased from 11.63% in 2006 to 30.94% in 2019. Overall, invasive diagnostic testing was used in 87.22% of AMA pregnancies. The prenatal detection rate of trisomy 21 and 18 increased from 74.1% and 83.3% in 2006 to 96.9% and 98.8% in 2019, respectively. Conclusion During the second-trimester and cFTS periods, the percentage of AMA pregnancies increased every year and the number of invasive procedures also accompany with increased percentage of AMA. However, during the period that NIPT were implemented, the percentage of invasive procedures decreased.

An Intelligent Prenatal Screening System for the Prediction of Trisomy-21

2020 ◽  
Author(s):  
Amir Jamshidnezhad ◽  
Seyed Mohsen Hosseini ◽  
Javad Mohammadi-Asl ◽  
Mandana Mahmoudi
Keyword(s):  
Neural Network ◽  
Down Syndrome ◽  
Screening Test ◽  
First Trimester ◽  
Diagnostic Methods ◽  
Screening Tests ◽  
Reference Laboratory ◽  
First Trimester Screening ◽  
Proposed Model ◽  
Trimester Screening

Abstract Objective: Early and accurate diagnosis of genetic diseases such as Down syndrome can lead to correct action and prevent irreversible events. Therefore, the use of accurate and low-risk diagnostic methods to detect these diseases in the fetal period is important. In this study, a combined artificial neural network (ANN) and genetic algorithm (GA) was used to predict Down syndrome through first trimester screening test. In order to examine the proposed model, sample data were collected on 381 pregnant women who referred to a private screening reference laboratory for the first trimester screening test and NT ultrasound between 11 and 13 weeks of gestation. The proposed model in this study was a feedforward neural which its structure and input parameters were determined by (GA).Results: The average of 10 times experiments showed that the developed model can accurately identify cases of Down syndrome with specificity of 99.72% and sensitivity of 90.91%, and a mean square error (MSE) of 0.61%. The results of this study showed that the use of GA in optimizing the structure of the neural network technique can increase the accuracy in diagnosing Down syndrome through the information of first trimester screening tests.

scholarly journals Combined First-Trimester Screening in Northern Finland: Experiences of the First Ten Years

2014 ◽  
Vol 8 ◽  
pp. CMRH.S14958
Author(s):  
Merilainen Anna ◽  
Peuhkurinen Sini ◽  
Honkasalo Timppa ◽  
Laitinen Paivi ◽  
Kokkonen Hannaleena ◽  
...  
Keyword(s):  
Detection Rate ◽  
False Positive Rate ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
First Trimester ◽  
First Trimester Screening ◽  
Invasive Procedures ◽  
Screening Performance ◽  
Positive Rate ◽  
Trimester Screening

Objective To evaluate the efficacy of first trimester combined screening for Down's syndrome in Northern Finland during the first 10 years of practice. Methods During 1 January 2002 to 31 December 2011, 47,896 women participated voluntarily in combined screening during first trimester. The risk cutoff was 1:250. The study period was divided into two time periods; 2002-2006 and 2007-2011. Results During the first half of the study period, the detection rate (DR) was 77.3% with a 4.9% false-positive rate (FPR). During the latter half, the DR was 77.1% with a 2.8% FPR. Conclusions An important issue is the number of invasive procedures needed to detect one case of Down's syndrome. The screening performance improved markedly in the latter five years period since the FPR lowered from 4.9% to 2.8% and the number of invasive procedures needed to detect one case of Down's syndrome lowered from 15 to 11.

scholarly journals Analysis of 42 Cases of First Trimester Screening in a Private Set-up

2011 ◽  
Vol 2 (2) ◽  
pp. 77-80
Author(s):  
Manasi Venkatraman ◽  
Sameer Dikshit ◽  
Ketan Gundavda
Keyword(s):  
First Trimester ◽  
Private Clinic ◽  
Screening Tests ◽  
First Trimester Screening ◽  
Standard Practice ◽  
Trimester Screening ◽  
Set Up

ABSTRACT Combined NT and first trimester biochemistry for aneuploidy has become a standard practice. This study was conducted in a busy private clinic. The results of this study showed that this study can be successfully performed in a busy private clinic. The results of the combined screening match those of the conventional screening tests. Proper counseling help the women to take a decision towards invasive testing in screen positive cases.

Trends in early prenatal screening for chromosomal abnormalities and congenital malformations in Russia in 2018

2020 ◽  
pp. 76-78
Author(s):  
Е.А. Калашникова ◽  
Е.Н. Андреева ◽  
П.А. Голошубов ◽  
Н.О. Одегова ◽  
Е.В. Юдина ◽  
...  
Keyword(s):  
Reference Values ◽  
Congenital Malformations ◽  
Prenatal Screening ◽  
Chromosomal Abnormalities ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
Overall Effectiveness ◽  
Regions Of Russia

В ходе анализа результатов раннего пренатального скрининга (РПС) в России за 2018 г. (Аудит-2019) дана оценка качества мероприятий, общей эффективности и тенденций развития системы РПС в субъектах РФ посредством сравнения рассчитанных основных организационных, методологических и интегральных показателей с международными референтными значениями. In the course of analyzing the results of early prenatal combined first-trimester screening (FTS) in Russia for 2018 (Audit-2019) the assessment of the quality of measures, the overall effectiveness and trends in the development of the FTS system in the regions of Russia. They are presented by comparing the calculated main organizational, methodological and integral indicators with international reference values.

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