Anatomopathological Correlation Between The Clinical Tumor Stage And The Cystectomy Piece

Objectives: For a better staging of bladder tumors, we studied the characteristics and the clinical tumor stage in a series of patients and we compared them with the anatomopathological results of cystectomy. Materials and methods: The clinical data of 126 patients who had had radical cystectomy with ilio-obturator dissection for bladder cancer in our department were analyzed retrospectively. Results: Of the 126 cases studied, 86% were men (109 cases) and 14% women , the average age in our series is 60 years. There was a correlation in 48.4% of the cases. The differences between clinical and pathological stages were statistically significant, the agreement was moderate with a percentage of 1.5% of pT0 at the cystectomy site (P <0.005). We found the following results: 100% of the 2 T0 tumors were T2. 80% of the 31 T1 tumors were T1, while 7 were T2; 28.3% of T2 tumors were T2, 11.6% were superficial tumors; 77.7% of T3 tumors were T3; 100% of T4 tumors were T4. Pathological lymph node involvement was diagnosed in 77 patients (61.1%) while only 19.8% was diagnosed with an abdominopelvic CT scan (P <0.005). Conclusion: This study demonstrated the high risk of the presence of an increase or decrease in the local stage of the primary tumor and of lymph node involvement.

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328: Accuracy of the Extent of Lymph Node Involvement Found at Pelvic Lymphadenectomy at the Time of Cystectomy in Patients with Bladder Cancer: Relation to Primary Tumor Stage

The Journal of Urology ◽

10.1016/s0022-5347(18)37590-6 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 86-86

Author(s):

Farhang Rabbani ◽

Harry W. Herr

Keyword(s):

Bladder Cancer ◽

Lymph Node ◽

Primary Tumor ◽

Tumor Stage ◽

Lymph Node Involvement ◽

Pelvic Lymphadenectomy ◽

Node Involvement

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Pilot study of [18F] fluorodexoyglucose positron emission tomography-magnetic resonance imaging (FDG-PET-MRI) for staging of muscle-invasive bladder cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.e16002 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. e16002-e16002

Author(s):

Patrick Eulitt ◽

Ersan Altun ◽

Arif Sheikh ◽

Terence Z. Wong ◽

Michael Woods ◽

...

Keyword(s):

Bladder Cancer ◽

Lymph Node ◽

Primary Tumor ◽

Fdg Pet ◽

Tissue Characterization ◽

Imaging Modality ◽

Preoperative Staging ◽

Lymph Node Involvement ◽

Imaging Results ◽

Node Involvement

e16002 Background: Standard of care imaging for staging MIBC is computed tomography (CT) abdomen and pelvis despite poor diagnostic accuracy. The addition of FDG-PET to evaluate biologic activity has been shown to improve detection of metastatic bladder cancer. Better soft tissue characterization with MRI may improve detection of local disease. We hypothesized that simultaneous acquisition of FDG-PET and MRI images (PET-MRI) would allow for more accurate preoperative staging in patients with MIBC. Methods: 21 patients with MIBC and planned radical cystectomy with lymph node dissection were enrolled. Four radiologists (2 senior, 2 junior) with expertise in MRI and PET independently reviewed MRI and FDG-PET scans, respectively, to determine: 1) extent of the primary bladder tumor; and 2) involvement of local lymph nodes and distant sites of disease. Combined radiologist reads were performed (senior MRI and junior PET and vice versa). Imaging results were compared to surgical pathology. Results: 18 patients were included in the final analysis (3 PET-MRI scans excluded due to technical pitfalls with image acquisition). Final pathology revealed 10 patients (56%) with muscle invasion and only 2 patients (11%) with lymph node involvement. Combined analyses of PET-MRI accurately detected the extent of the primary tumor (sensitivity 0.84, specificity 0.50, PPV 0.70, NPV 0.70), but was less accurate for the detection of lymph node involvement (sensitivity 0.00, specificity 1.00, no calculable PPV, NPV 0.91). Senior MRI radiologist had improved PPV and NPV for extent of primary tumor compared to junior MRI radiologist (PPV 0.71 vs 0.56, NPV 0.83 vs. 0.50), and senior PET radiologist had improved PPV with similar NPV for extent of primary tumor (PPV 1.00 vs 0.78, NPV 0.50 vs 0.55). No patient was determined to have distant metastatic disease. Conclusions: To our knowledge, this is the first study exploring the use of PET-MRI for staging MIBC. This novel imaging modality demonstrated promise in detecting the extent of the primary tumor. Further investigation of FDG-PET-MRI is needed to better determine its potential utility in staging MIBC.

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Prognostic implications of lymph node involvement in bladder cancer: are we understaging using current methods?

BJU International ◽

10.1111/j.1464-410x.2011.10330.x ◽

2011 ◽

Vol 108 (4) ◽

pp. 484-492 ◽

Cited By ~ 13

Author(s):

Kara L. Watts ◽

Benjamin T. Ristau ◽

Harold T. Yamase ◽

John A. Taylor III

Keyword(s):

Bladder Cancer ◽

Lymph Node ◽

Lymph Node Involvement ◽

Node Involvement ◽

Prognostic Implications

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The Role of BiP and the IRE1α–XBP1 Axis in Rhabdomyosarcoma Pathology

Cancers ◽

10.3390/cancers13194927 ◽

2021 ◽

Vol 13 (19) ◽

pp. 4927

Author(s):

Mahmoud Aghaei ◽

Ahmad Nasimian ◽

Marveh Rahmati ◽

Philip Kawalec ◽

Filip Machaj ◽

...

Keyword(s):

Skeletal Muscle ◽

Lymph Node ◽

Tumor Development ◽

Tumor Stage ◽

Lymph Node Involvement ◽

P Value ◽

Adult Disease ◽

Specific Tumor ◽

Node Involvement ◽

The Unfolded Protein Response

Background: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children, and is associated with a poor prognosis in patients presenting with recurrent or metastatic disease. The unfolded protein response (UPR) plays pivotal roles in tumor development and resistance to therapy, including RMS. Methods: In this study, we used immunohistochemistry and a tissue microarray (TMA) on human RMS and normal skeletal muscle to evaluate the expression of key UPR proteins (GRP78/BiP, IRE1α and cytosolic/nuclear XBP1 (spliced XBP1-sXBP1)) in the four main RMS subtypes: alveolar (ARMS), embryonal (ERMS), pleomorphic (PRMS) and sclerosing/spindle cell (SRMS) RMS. We also investigated the correlation of these proteins with the risk of RMS and several clinicopathological indices, such as lymph node involvement, distant metastasis, tumor stage and tumor scores. Results: Our results revealed that the expression of BiP, sXBP1, and IRE1α, but not cytosolic XBP1, are significantly associated with RMS (BiP and sXBP1 p-value = 0.0001, IRE1 p-value = 0.001) in all of the studied types of RMS tumors (n = 192) compared to normal skeletal muscle tissues (n = 16). In addition, significant correlations of BiP with the lymph node score (p = 0.05), and of IRE1α (p value = 0.004), cytosolic XBP1 (p = 0.001) and sXBP1 (p value = 0.001) with the stage score were observed. At the subtype level, BiP and sXBP1 expression were significantly associated with all subtypes of RMS, whereas IRE1α was associated with ARMS, PRMS and ERMS, and cytosolic XBP1 expression was associated with ARMS and SRMS. Importantly, the expression levels of IRE1α and sXBP1 were more pronounced in ARMS than in any of the other subtypes. The results also showed correlations of BiP with the lymph node score in ARMS (p value = 0.05), and of sXBP1 with the tumor score in PRMS (p value = 0.002). Conclusions: In summary, this study demonstrates that the overall UPR is upregulated and, more specifically, that the IRE1/sXBP1 axis is active in RMS. The subtype and stage-specific dependency on the UPR machinery in RMS may open new avenues for the development of novel targeted therapeutic strategies and the identification of specific tumor markers in this rare but deadly childhood and young-adult disease.

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