scholarly journals AN IMPACT OF INTRAABDOMINAL HYPERTENSION ON BLOOD BIOCHEMICAL AND RHEOLOGICAL CHANGES AFTER SURGICAL TREATMENT OF ACUTE INTESTINAL OBSTRUCTION IN AN EXPERIMENT

2012 ◽  
Vol 11 (4) ◽  
pp. 34-38
Author(s):  
V. Yu. Bodiaka
Author(s):  
А.А. Коваленко ◽  
В.К. Хугаева

Высокая смертность при хирургическом лечении острой кишечной непроходимости (ОКН) определила поиск новых методов сопутствующей терапии. Обнаруженная ранее высокая эффективность опиоидных пептидов в стимулировании лимфотока в микрососудах брыжейки тонкой кишки у крыс, восстановлении нарушенной микроциркуляцию и снижении смертности при ряде заболеваний, определила цель данного исследования: изучить роль фармакологической стимуляции лимфотока в динамике ОКН. В работе использовали методы: биомикроскопия, лазерная допплеровская флоуметрия брыжейки и стенки тонкой кишки крысы, регистрация сократительной активности лимфатических микрососудов ЛМ методом фотометрии, морфометрия микрососудов, видео- и фотосъемка. Полученные результаты предполагают наличие адаптационной роли у активатора микролимфоциркуляции (опиоидного пептида-171 прямого действия) в комплексном хирургическом лечении ОКН. Однократное орошение пептидом межкишечного анастомоза (после удаления) и поврежденного лигатурой фрагмента кишки (перед зашиванием операционной раны) увеличивало выживаемость животных с ОКН на 23%. У всех выживших животных отмечено восстановление: проходимости кишки, микроциркуляции в кровеносных и лимфатических микрососудах, а также структуры стенки кишки. High mortality in the surgical treatment of acute intestinal obstruction (AIO) has warranted the search for new methods of concomitant therapy. Opioid peptides have proved highly effective in stimulating the lymphatic flow in rat small intestinal mesenteric microvessels, restoring the impaired microcirculation, and reducing mortality in many diseases. This had determined this study objective: to investigate the role of lymphatic stimulation in the dynamics of AIO. The study used methods of biomicroscopy, laser Doppler flowmetry, and histological examination of the mesentery and the small intestinal wall in rats; recording the contractile activity of lymphatic microvessels using photometry; microvessel morphometry; video and photography. The study results suggested an adaptive role of the lymphatic microcirculation activator (direct-action opioid-171) in the complex surgical treatment of AIO. A one-time peptide irrigation of the intestinal anastomosis (after removal) and the intestinal injuried by the ligature (before the surgical wound was sutured) increased the survival of animals with AIO by 23%. In all surviving animals, recovery of the intestinal patency, blood and lymphatic microcirculation, and the intestinal wall structure was observed.


2021 ◽  
pp. 37-41
Author(s):  
M. A. Kashtalyan ◽  
V. Y. Shapovalov ◽  
R. V. Yenin ◽  
M. О. Koshicov ◽  
S. O. Pasternachenko

Summary. Objective: to improve the results of surgical treatment of patients with acute intestinal obstruction of tumor origin. Materials and methods of research. During the period from 2014 to 2020 in the surgical clinics of the Military Medical Clinical Center of the Southern Region (Odessa) 186 patients were treated with acute obstructive colonic obstruction of tumor origin. Research results and their discussion. In 34 (18.3 %) patients with GOKN during the applied conservative measures positive dynamics was observed, which allowed to examine patients in detail and prepare for surgery. In 6 (3.2 %) elderly patients with severe comorbidities, tumor recanalization and stent placement were performed. In 146 (78.5 %) patients, conservative measures were unsuccessful and were operated on according to vital signs, the first stage of which was intestinal fatigue. Conclusions. Step-by-step tactics of surgical treatment of acute intestinal obstruction of tumor origin with the use of laparoscopic colostomy in the first stage were used in 60.3 % of patients, which allowed final verification of the diagnosis, safe compensation of electrolyte and nutritional disorders in the patient and further treatment and correction.


Author(s):  
Zemlyanoy V. Р. P. Zemlyanoy ◽  
B. V. Sigua ◽  
D. S. Syomin ◽  
D. V. Gurzhiy ◽  
D. H. Qalandarova

Damage to the gastrointestinal tract with extragenital endometriosis is a very rare pathology. According to the literature, the frequency of damage to the gastrointestinal tract in endometriosis, after previously performed gynecological operations, is less than 1%. At the same time, involvement in the pathological process of the intestine is noted in 337% of women of childbearing age with diagnosed genital endometriosis. In most clinical cases extragenital endometriosis occurs intraoperatively due to the complexity of early diagnosis. This article presents a clinical case of successful surgical treatment of a 43-year-old patient admitted to a surgical department with signs of intestinal obstruction. According to the anamnesis the patient had been suffering from recurrent pains in the lower abdomen in the right mesogastrium and constipation. The day before hospitalization, the above mentioned symptoms become worse with additional nausea, vomiting, lack of gases and feces. Based on the clinical laboratory and instrumental data the diagnosis of acute intestinal obstruction was established; and the urgent surgical treatment was carried out. Two formations were revealed intraoperatively (in the terminal ileum and in the elongated loop of the sigmoid colon). Both formations circularly narrowed the intestinal lumen, however the ileum was the cause of obstruction. Due to the lack of histological verification and the inability to exclude the malignant nature of the formation, the surgical treatment was carried out taking into account oncological standard in the amount of ileum resection and obstructive resection of the sigmoid colon with lymphadenectomy and small intestine intubation. Pathohistological examination confirmed intestinal endometriosis. The course of the postoperative period revealed no complications. The patient was discharged on the 12th day for outpatient treatment under the supervision of a surgeon and a gynecologist at the place of residence with recommendations and subsequent planned hospitalization in order to conduct reconstructive surgery to restore intestinal patency.


2019 ◽  
Vol 23 (1) ◽  
pp. 48-49
Author(s):  
A. N. Smirnov ◽  
M. A. Pronichev ◽  
Nadezhda B. Kireeva ◽  
N. M. Ganyushkin

In children, foreign bodies of the gastrointestinal tract (GIT) are common, 80-90% of them pass through the GIT without any problem. However, in some cases the clinical picture of peritonitis, intestinal obstruction, bleeding develops, which requires surgical treatment. Described in the article the clinical observation of acute intestinal obstruction in an 11-month-old child, after he has swallowed a hydrogel ball, will be useful for practicing pediatric surgeons.


2020 ◽  
Vol 24 (2) ◽  
pp. 37-45
Author(s):  
Ildar Mugallimovich Sharafutdinov ◽  
◽  
Marat Faritovich Minniakhmetov ◽  
Vladimir Petrovich Ionin ◽  

A clinical case of successful surgical treatment of acute intestinal obstruction due to a neuroendocrine tumor of the small intestine in a patient against a new coronovirus infection COVID-19 is described.


2020 ◽  
Vol 24 (3) ◽  
pp. 409-412
Author(s):  
V. V. Kernychnyi ◽  
A. I. Sukhodolya

Annotation. The article presented a rare clinical case of a successful treatment of cancer of the descending colon, that is complicated by acute obstructive intestinal obstruction on the background of post-traumatic left diaphragmatic hernia in a 68-year-old patient. The result of surgical treatment indicates some possible unexpected intraoperative difficulties that the surgeon might be facing with during the process of a surgery. It is noticed that in surgery for a cancer of the descending colon, had been complicated by an acute intestinal obstruction, it is still necessary to find the cause of abdominal pain, had been accompanied by bloating, lack of stool and gas, vomiting “feils”, one of which may be postpartum of left hernia of the diaphragm.


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