scholarly journals Register of myocardial infarction in Northern Bukovyna: neurohumoral disorders in acute heart failure

2013 ◽  
Vol 17 (2 (66)) ◽  
pp. 37-40
Author(s):  
O. I. Hulaga ◽  
V. K. Tashchuk ◽  
O. S. Polianska
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Stroke Volume ◽  
Atrial Natriuretic Peptide ◽  
Acute Heart Failure ◽  
Natriuretic Peptide ◽  
Clinical Manifestations ◽  
Minute Volume ◽  
Relationship Of ◽  
Atrial Natriuretic

In patients with acute myocardial infarction with clinical manifestations of acute heart failure (Killip II) significantly lower rates of the stroke volume of blood (p<0,01), minute volume of blood (p<0,001), significantly high indices of the level of aldosterone (p<0,05) and atrial natriuretic peptide (p <0,05). A negative correlative relationship of the atrial natriuretic peptide concentration with the magnitude of the stroke volume of blood (p<0,05), ejection fraction (p<0,01) and the minute volume of blood (p<0,05) has been detected.

N-terminal pro-atrial natriuretic peptide (N-ANP) and N-terminal pro-B-type natriuretic peptide (N-BNP) in the prediction of death and heart failure in unselected patients following acute myocardial infarction

2004 ◽  
Vol 107 (3) ◽  
pp. 309-316 ◽  
Author(s):  
Iain B. SQUIRE ◽  
Russell J. O'BRIEN ◽  
Bettina DEMME ◽  
Joan E. DAVIES ◽  
Leong L. NG
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Risk Of Death ◽  
Number Of Patients ◽  
Patients At Risk ◽  
Relationship Of ◽  
Atrial Natriuretic

Elevated plasma natriuretic peptide levels after AMI (acute myocardial infarction) are associated with adverse outcome. The aim of the present study was to examine the relationship of plasma N-ANP (N-terminal pro-atrial natriuretic peptide) and N-BNP (N-terminal pro-B-type natriuretic peptide) with mortality and heart failure following AMI. We studied 403 patients with AMI. Blood was sampled for measurement of N-ANP and N-BNP on a single occasion between 72 and 96 h after symptom onset. Natriuretic peptide levels were related to all-cause mortality and heart failure episodes. During follow up (median, 462 days; range 5–764), 43 (10.7%), 25 (6.2%) and 49 (12.2%) patients suffered death, heart failure hospitalization and outpatient heart failure respectively. Only N-BNP (P<0.0005), N-ANP (P=0.005) and previous AMI (P=0.016) were independently predictive of death. N-BNP, but not N-ANP, predicted 30-day mortality. N-ANP, but not N-BNP, predicted mortality after 30 days. N-BNP was the better predictor of heart failure. N-ANP and N-BNP were above the median in 35 and 38 respectively, of 43 patients who later died. N-ANP, N-BNP, or both were above the median in 41 out of 43 patients. Of 25 patients hospitalized with heart failure, N-ANP and N-BNP was above the median in 20 and 24 respectively, and one or other was elevated in all cases. Above-median N-ANP predicted 36 and N-BNP predicted 41 out of 49 episodes of outpatient heart failure. One or other peptide was above the median in 45 out of 49 patients. Our results indicate that N-BNP predicts 30-day and N-ANP >30-day mortality. We conclude that consideration of both N-ANP and N-BNP identifies a greater number of patients at risk of death or heart failure than either peptide alone.

scholarly journals Mid‐regional pro‐atrial natriuretic peptide for the early detection of non‐acute heart failure

2019 ◽  
Vol 21 (10) ◽  
pp. 1219-1227 ◽  
Author(s):  
Aisha Gohar ◽  
Frans H. Rutten ◽  
Hester Ruijter ◽  
Johannes C. Kelder ◽  
Stephan Haehling ◽  
...  
Keyword(s):  
Heart Failure ◽  
Early Detection ◽  
Atrial Natriuretic Peptide ◽  
Acute Heart Failure ◽  
Natriuretic Peptide ◽  
Atrial Natriuretic

Atrial natriuretic peptide transcription, storage, and release in rats with myocardial infarction

1987 ◽  
Vol 253 (6) ◽  
pp. H1449-H1455 ◽  
Author(s):  
R. E. Mendez ◽  
J. M. Pfeffer ◽  
F. V. Ortola ◽  
K. D. Bloch ◽  
S. Anderson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Chronic Heart Failure ◽  
Atrial Natriuretic Peptide ◽  
Infarct Size ◽  
Natriuretic Peptide ◽  
Left Ventricular ◽  
Coronary Artery Ligation ◽  
Mrna Levels ◽  
Atrial Natriuretic

To study the role of atrial natriuretic peptide (ANP) in chronic heart failure, ANP synthesis, storage, and release were examined by measuring atrial ANP messenger ribonucleic acid (mRNA) levels and atrial and plasma ANP concentrations in rats with myocardial infarction produced by coronary artery ligation. Three groups were defined as the following: 1) controls, sham-operated, or operated, but noninfarcted; 2) moderate infarcts, involving 5-30% of the left ventricular circumference; and 3) large infarcts (greater than or equal to 30%). In addition, to determine a possible modulation by dietary Na intake on ANP levels in heart failure, plasma immunoreactive ANP (iANP) levels were measured in rats with and without infarcts given low, regular, or high Na intake for 2 wk, by which time all groups were in neutral balance. Plasma iANP levels varied directly with increasing infarct and atrial sizes, irrespective of Na intake. In contrast, atrial ANP concentration varied inversely with increasing infarct size. The ANP mRNA content index, a measure of total atrial ANP mRNA, was significantly increased in rats with large infarcts compared with control rats. These results indicate that in rats with myocardial infarction, the severity of left ventricular dysfunction, as inferred from infarct size, but not chronic Na intake, is the primary determinant of the extent of activation of the ANP system. Elevated circulating ANP levels are maintained through enhanced atrial synthesis and release. ANP may thus play an important role in the hemodynamic and renal adaptations to chronic heart failure.

Atrial natriuretic peptide levels during development of chronic heart failure after myocardial infarction in rats

Life Sciences ◽  
1987 ◽  
Vol 40 (20) ◽  
pp. 2025-2030 ◽  
Author(s):  
Richard W. Lee ◽  
Richard G. Gay ◽  
Cassandra Moffett ◽  
David G. Johnson ◽  
Steven Goldman
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Chronic Heart Failure ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Atrial Natriuretic
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