scholarly journals Preventive pharmacotherapy of type 2 diabetes mellitus in patients with early carbohydrate metabolism disorders: long-term efficacy and clinical outcomes

2020 ◽  
Author(s):  
V.V. Boeva ◽  
A.N. Zavyalov
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Carbohydrate Metabolism ◽  
Lifestyle Modification ◽  
Term Therapy ◽  
Medication Therapy

Prevention of type 2 diabetes mellitus (T2DM) in prediabetic patients is a pressing concern due to its increasing prevalence. The aim of this study was to evaluate the efficacy of preventive pharmacotherapy in delaying progression of incident impaired glucose tolerance (IGT) and impaired fasting glycemia (IFG) to T2DM. The participants of the study (1,136 subjects) found healthy by a regular annual checkup underwent repeat screening for T2DM. Blood samples were processed following the guidelines for good preanalytical sample preparation. Patents with incident IGT/IFG were prescribed medication therapy with metformin or/and acarbose. The rate of IGT/IFG conversion to T2DM was evaluated in years 3 and 10 of observation. Carbohydrate metabolism disorders were detected in 18.5% (n = 210) of the re-screened patients: 5.0% had T2DM, 5.5% had IGT, 8.0% had IFG. Patients with incident T2DM were prescribed blood sugar lowering therapy and they were excluded from further analysis. Patients with IGT/IFG (n = 151) were given recommendations on lifestyle modification and prescribed metformin (77%) or a combination of metformin and acarbose (23%). Three years after the start of observation, the rate of conversion to T2DM was 6.8% in patients undergoing monotherapy with metformin and 11.4% in patients undergoing combination therapy with metformin and acarbose. After the active follow-up phase was over, the majority of the patients (n = 85) decided to discontinue preventive therapy without consulting their physicians. Ten years after the active follow-up phase, the rate of NGT/IFG conversion to T2DM was 38.8% in patients who had discontinued their treatment and 0% in patients still taking metformin (p < 0.01). Long-term therapy with metformin prevented progression to T2DM in the long run in 83.3% (p < 0.05).

Comparative Efficacy and Potency of Long-Term Therapy with Glipizide or Glyburide in Patients with Type 2 Diabetes Mellitus

2000 ◽  
Vol 319 (3) ◽  
pp. 143-148
Author(s):  
Kitabchiphd Abbas E. ◽  
Elizabeth Kaminska ◽  
Joseph N. Fisher ◽  
Amy Sherman ◽  
Pitts Kathy ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Term Therapy ◽  
Comparative Efficacy ◽  
Long Term Therapy

Comparative Efficacy and Potency of Long-Term Therapy with Glipizide or Glyburide in Patients with Type 2 Diabetes Mellitus

2000 ◽  
Vol 319 (3) ◽  
pp. 143-148 ◽  
Author(s):  
Abbas E. Kitabchi ◽  
Elizabeth Kaminska ◽  
Joseph N. Fisher ◽  
Amy Sherman ◽  
Kathy Pitts ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Term Therapy ◽  
Comparative Efficacy ◽  
Long Term Therapy

scholarly journals QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up

Diabetologia ◽  
2006 ◽  
Vol 50 (1) ◽  
pp. 186-194 ◽  
Author(s):  
C. Stettler ◽  
A. Bearth ◽  
S. Allemann ◽  
M. Zwahlen ◽  
L. Zanchin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Type 2 Diabetes Mellitus ◽  
Qtc Interval ◽  
Resting Heart Rate

scholarly journals Effectiveness of Lifestyle Modification Counseling on Glycemic Control in Type 2 Diabetes Mellitus Patients

2018 ◽  
Vol 6 (1) ◽  
pp. 70-82 ◽  
Author(s):  
Vikram Singh ◽  
Ashok Kumar Jhingan ◽  
Saurabh Dahiya ◽  
Girija Kumari
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Blood Sugar ◽  
Lifestyle Intervention ◽  
Lifestyle Modification ◽  
Holistic Model

This study was carried out to assess the effectiveness of lifestyle modification counseling using lifestyle intervention holistic model and its adherence towards glycemic control in type 2 diabetes mellitus patients. This quasi-experimental prospective study was conducted among 224 type 2 diabetes mellitus patients in Delhi Diabetes Research Center, New Delhi. The study participants were allocated to lifestyle modification counseling group (intervention) and usual care (control) group based on receiving or not receiving lifestyle modification counseling using lifestyle intervention holistic model. Effect of counseling on glycemic control was assessed at baseline and follow up of both the groups at 3rd, 6th and 12th months after receiving lifestyle modification counseling. The collected data was analyzed for percentage, mean, median, standard deviation, chi-squared, t-test and Wilcoxon test. In this study, the lifestyle modification counseling proved to be effective and showed significant improvement in fasting blood sugar (175.5±32.3 to 144.7±17.6), postprandial blood sugar (275.5±61. to199.0±48.3), hemoglobin A1c by 9.3±1.5 to 8.4±1.3. Significant improvement was observed in diastolic blood pressure (82.6±7.0 to79.4±6.1) and high-density lipoproteins cholesterol (47.3±10.5 to 58.8±5.6) from 3rd to 12th months follow up with significant p value 0.001 in the intervention group. The study showed good adherence to balanced diet, physical activity, and tobacco and alcohol cessation but less adherence was observed towards meditation for stress management, regular checkups, and medicine adherence. Lifestyle modification counseling is an effective, noninvasive approach towards glycemic control in type 2 diabetes mellitus patients. Lifestyle intervention holistic model used in this counseling may be helpful for type 2 diabetes mellitus patients to improve adherence and self-care behavior towards the management of their diabetes.

scholarly journals Glomerular Permselectivity at the Onset of Nephropathy in Type 2 Diabetes Mellitus

2000 ◽  
Vol 11 (11) ◽  
pp. 2095-2105
Author(s):  
KEVIN V. LEMLEY ◽  
KRISTINA BLOUCH ◽  
ISHA ABDULLAH ◽  
DEREK B. BOOTHROYD ◽  
PETER H. BENNETT ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pima Indians ◽  
Glomerular Injury ◽  
Control Subjects ◽  
Glomerular Barrier

Abstract. The development of microalbuminuria in individuals with type 2 diabetes mellitus is associated with a 10-fold increase in the risk of progression to overt nephropathy and eventual end-stage renal failure. The present study reports long-term (up to 8 yr) follow-up of 43 Pima Indians with type 2 diabetes detected on screening to have microalbuminuria. The natural history of albuminuria in these individuals included progression to overt proteinuria (urinary albumin excretion ≥ 300 mg/d) in half of the participants by 7 yr of follow-up. The size selectivity of the glomerular barrier was also investigated using dextran sieving and pore theory. Whereas a comparison group of macroalbuminuric Pima Indians had an excess of large pores that served as a macromolecular “shunt,” individuals with microalbuminuria had a shunt size no different from long-term diabetic, normoalbuminuric control subjects. An abrupt transition from little or no relationship to a highly significant and positive relationship between increasing albuminuria and shunt size occurred at an albumin-to-creatinine ratio of approximately 3000 mg/g. Shunt size in macroalbuminuric individuals correlated with the extent of foot process broadening. Podocyte foot processes in microalbuminuric participants were not different from those in control subjects. In conclusion, although microalbuminuria in type 2 diabetic Pima Indians often heralds progressive glomerular injury, it is not the result of defects in the size permselectivity of the glomerular barrier but rather of changes in either glomerular charge selectivity or tubular handling of filtered proteins or of a combination of these two factors.

Biliopancreatic diversion, type 2 diabetes mellitus and metabolic syndrome: Long-term follow-up study

2005 ◽  
Vol 1 (3) ◽  
pp. 273
Author(s):  
Gian Franco Adami ◽  
Francesco Papadia ◽  
Giuseppe Marinari ◽  
Giovanni Camerini ◽  
Nicola Scopinaro
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Biliopancreatic Diversion ◽  
Follow Up Study ◽  
Long Term Follow Up

scholarly journals Long-term patterns of adherence to medication therapy among patients with type 2 diabetes mellitus in Denmark: The importance of initiation

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179546 ◽  
Author(s):  
Majken Linnemann Jensen ◽  
Marit Eika Jørgensen ◽  
Ebba Holme Hansen ◽  
Lise Aagaard ◽  
Bendix Carstensen
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Medication Therapy ◽  
Adherence To Medication
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