MODERN VIEWS ON GASTROESOPHAGEAL REFLUX DISEASE IN CHILDREN: ISSUES OF CLASSIFICATION, ETIOLOGY AND PATHOGENESIS (PART I)

2021 ◽  
Vol 100 (6) ◽  
pp. 85-91
Author(s):  
N.N. Akhparov ◽  
◽  
R.Z. Boranbaeva ◽  
S.B. Suleimanova ◽  
L.N. Manzhuova ◽  
...  
Keyword(s):  
Minimally Invasive Surgery ◽  
Surgical Treatment ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Scientific Literature ◽  
Surgical Intervention ◽  
Molecular Genetic ◽  
Cytogenetic Studies

The review is devoted to modern views on the etiology, pathogenesis, clinical picture, methods of diagnosis and surgical treatment of gastroesophageal reflux disease (GERD) in children. An analysis of scientific literature by domestic and foreign authors on the evolution of molecular genetic and cytogenetic studies, the role of morphological and immunohistochemical mechanisms in diagnostics is presented, the researchers’ opinions regarding the timing and tactics of surgical intervention, as well as the advantages of minimally invasive surgery for GERD are considered.

scholarly journals MODERN VIEWS ON ETIOLOGY AND PATHOGENESIS OF CYSTIC-ADENOMATOUS PULMONARY MALFORMATION IN CHILDREN. PART I

2019 ◽  
Vol 23 (2) ◽  
pp. 78-85
Author(s):  
Saule B. Suleymanova
Keyword(s):  
Minimally Invasive Surgery ◽  
Surgical Treatment ◽  
Lung Diseases ◽  
Scientific Literature ◽  
Surgical Intervention ◽  
Molecular Genetic ◽  
Postnatal Diagnosis ◽  
Cytogenetic Studies ◽  
Number Of Authors

The review is devoted to modern ideas of etiology, pathogenesis, methods of diagnosis and surgical treatment of cystic adenomatous malformation in children. There was performeв the analysis of the scientific literature of domestic and foreign authors, the evolution of molecular genetic and cytogenetic studies was described, the role of histochemical and ultrastructural analysis in pre- and postnatal diagnosis of congenital lung diseases in children was considered. The opinions of a number of authors on the timing and tactics of surgical intervention, as well as the advantages of minimally invasive surgery for congenital lung developmental anomalies, are presented.

The Role of Laparoscopic Anti-Reflux Surgery in Obese Patients with Gastroesophageal Reflux Disease

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Flores Edgar Vargas ◽  
Cortez Juan Carlos Quintana ◽  
Contreras Jose Luis Ledesma ◽  
Medina Yazmin Berrones ◽  
Zhou Lucero Chao
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Obese Patients

scholarly journals Surgical treatment of recalcitrant gastroesophageal reflux disease in patients with systemic sclerosis: a systematic review

2021 ◽  
Author(s):  
Alberto Aiolfi ◽  
Mario Nosotti ◽  
Kazuhide Matsushima ◽  
Carolina Perali ◽  
Cristina Ogliari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Systemic Sclerosis ◽  
Surgical Treatment ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Current Data ◽  
Current Evidence ◽  
Increased Risk

Abstract Introduction Gastroesophageal reflux disease (GERD) is frequently seen in patients with systemic sclerosis (SSc). Long-standing GERD may cause esophagitis, long-segment strictures, and Barrett’s esophagus and may worsen pre-existing pulmonary fibrosis with an increased risk of end-stage lung disease. Surgical treatment of recalcitrant GERD remains controversial. The purpose of this systematic review was to summarize the current data on surgical treatment of recalcitrant GERD in SSc patients. Materials and methods A systematic literature review according to PRISMA and MOOSE guidelines. PubMed, EMBASE, and Web of Science databases were consulted. Results A total of 101 patients were included from 7 studies. The age ranged from 34 to 61 years and the majority were females (73.5%). Commonly reported symptoms were heartburn (92%), regurgitation (77%), and dysphagia (74%). Concurrent pulmonary disease was diagnosed in 58% of patients. Overall, 63 patients (62.4%) underwent open fundoplication, 17 (16.8%) laparoscopic fundoplication, 15 (14.9%) Roux en-Y gastric bypass (RYGB), and 6 (5.9%) esophagectomy. The postoperative follow-up ranged from 12 to 65 months. Recurrent symptoms were described in up to 70% and 30% of patients undergoing fundoplication and RYGB, respectively. Various symptoms were reported postoperatively depending on the type of surgical procedures, anatomy of the valve, need for esophageal lengthening, and follow-up. Conclusions The treatment of recalcitrant GERD in SSc patients is challenging. Esophagectomy should be reserved to selected patients. Minimally invasive RYGB appears feasible and safe with promising preliminary short-term results. Current evidence is scarce while a definitive indication about the most appropriate surgical treatment is lacking.

Role of the c825t polymorphic locus of G-protein beta subunit (GNBβ3) in patients with gastroesophageal reflux disease

Therapy ◽  
2021 ◽  
Vol 9_2021 ◽  
pp. 46-50
Author(s):  
Zhilina A.A. Zhilina ◽  
Lareva N.V. Lareva ◽  
Luzina E.V. Luzina ◽  
Zhigula Z.M. Zhigula Z ◽  
Tomina E.A. Tomina ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
G Protein ◽  
Reflux Disease ◽  
Polymorphic Locus ◽  
Beta Subunit

scholarly journals THE EFFICACY OF THE DIFFERENT ENDOSCOPIC TREATMENTS VERSUS SHAM, PHARMACOLOGIC OR SURGICAL METHODS FOR CHRONIC GASTROESOPHAGEAL REFLUX DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS

2018 ◽  
Vol 55 (3) ◽  
pp. 296-305 ◽  
Author(s):  
Martin Andrés CORONEL ◽  
Wanderley Marques BERNARDO ◽  
Diogo Turiani Hourneaux de MOURA ◽  
Eduardo Turiani Hourneaux de MOURA ◽  
Igor Braga RIBEIRO ◽  
...  
Keyword(s):  
Systematic Review ◽  
Surgical Treatment ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Meta Analysis ◽  
Short Term ◽  
Significant Difference ◽  
Objective Outcomes

ABSTRACT BACKGROUND: Endoscopic antireflux treatments for gastroesophageal reflux disease (GERD) are still evolving, and most of the published studies address symptom relief in the short-term. Objective - We aimed to perform a systematic review and meta-analysis focused on evaluating the efficacy of the different endoscopic procedures. METHODS: Search was restricted to randomized controlled trials (RCTs) on MedLine, Cochrane, SciELO, and EMBASE for patients with chronic GERD (>6 months), over 18 years old and available follow up of at least 3 months. The main outcome was to evaluate the efficacy of the different endoscopic treatments compared to sham, pharmacological or surgical treatment. Efficacy was measured by different subjective and objective outcomes. RESULTS: We analyzed data from 16 RCT, totaling 1085 patients. The efficacy of endoscopic treatments compared to sham and proton pump inhibitors (PPIs) treatment showed a significant difference up to 6 months in favor of endoscopy with no heterogeneity (P<0.00001) (I2: 0%). The subgroup analysis showed a statistically significant difference up to 6 months in favor of endoscopy: endoscopy vs PPI (P<0.00001) (I2: 39%). Endoscopy vs sham (P<0.00001) (I2: 0%). Most subjective and objective outcomes were statistically significant in favor of endoscopy up to 6 and 12 months follow up. CONCLUSION: This systematic review and meta-analysis shows a good short-term efficacy in favor of endoscopic procedures when comparing them to a sham and pharmacological or surgical treatment. Data on long-term follow up is lacking and this should be explored in future studies.

scholarly journals Early experiences of minimally invasive surgery to treat gastroesophageal reflux disease

2013 ◽  
Vol 84 (6) ◽  
pp. 330 ◽  
Author(s):  
Sae Byul Lee ◽  
Kyoung Mo Jeon ◽  
Beom Su Kim ◽  
Kab Choong Kim ◽  
Hwoon-Yong Jung ◽  
...  
Keyword(s):  
Minimally Invasive Surgery ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Minimally Invasive ◽  
Invasive Surgery ◽  
Reflux Disease ◽  
Early Experiences
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