Relevance and management of secondary hypogammaglobulinema in clinical practice

Advance protocols for the treatment most of oncology, hematology and some inherited disorders may lead to development severe secondary hypogammaglobulinaemia. Particularly, it is often caused by therapy with monoclonal antibodies binding B-cells (such as rituximab, belimumab, inotuzumab), therapy with inhibitors of tyrosine-kinase (imatinib, desatinib), as well as applying a variety of immunosuppressive and chemotherapy agents (steroids, azathioprine, cyclophosphamide etc.). It should be note, that chronic lymphoid leukemia and multiple myeloma could be complicated with hypogammaglobulinaemia, not only because of specific therapy, but also as features of the diseases. Hematopoietic stems cells transplantation can also lead to development severe and prolonged hypogammaglobulinaemia. This is associated with intensive immune/myeloablative therapy, as well as with immunologic reconstitution after transplantation. Modern intravenous immunoglobulins (IVIG) have a wide repertoire of pathogen-specific activity with high safety profile and constitute essential part of therapy patients with secondary hypogammaglobulinaemia. The paper presents literature review of IVIG usage in various clinical situations, as well as several clinical examples of personal experience.

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Faculty Opinions recommendation of Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.12661956.14635213 ◽

2011 ◽

Author(s):

Ramsay Fuleihan ◽

Joy Hsu

Keyword(s):

T Cells ◽

Chimeric Antigen Receptor ◽

Antigen Receptor ◽

Lymphoid Leukemia ◽

Chronic Lymphoid Leukemia

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Faculty Opinions recommendation of Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.12661956.14036057 ◽

2011 ◽

Author(s):

Christopher Thanos

Keyword(s):

T Cells ◽

Chimeric Antigen Receptor ◽

Antigen Receptor ◽

Lymphoid Leukemia ◽

Chronic Lymphoid Leukemia

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Comparison between Anthracyclines and Rhodamine-123 Accumulation in Chronic Lymphoid Leukemia: Effect of Cyclosporin A and Verapamil

Tumor Biology ◽

10.1159/000029973 ◽

1998 ◽

Vol 19 (1) ◽

pp. 41-51 ◽

Cited By ~ 7

Author(s):

Raquel C. Maia ◽

Flávia C. Vasconcelos ◽

Ramza C. Harab ◽

Arthur Moellman Coelho ◽

Jane A. Dobbin ◽

...

Keyword(s):

Cyclosporin A ◽

Rhodamine 123 ◽

Lymphoid Leukemia ◽

Chronic Lymphoid Leukemia

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Epileptic Seizure Provoked by Bone Metastasis of Chronic Lymphoid Leukemia and Merkel Cell Carcinoma – Case Report

10.21203/rs.2.358/v1 ◽

2019 ◽

Author(s):

András Folyovich ◽

Angéla Majoros ◽

Tamás Jarecsny ◽

Gitta Pánczél ◽

Zsuzsanna Pápai ◽

...

Keyword(s):

Bone Metastases ◽

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Cerebral Metastasis ◽

Merkel Cell ◽

Lymphoid Leukemia ◽

Chronic Lymphoid Leukemia ◽

History Of ◽

The Right ◽

The Brain

Abstract Background Merkel cell carcinoma (MCC) is a rare primary neuroendocrine cutaneous tumor, rarely metastatizing to the brain. Chronic lymphoid leukemia (CLL) is a disease predisposing to MCC. According to previous reports, headache and focal neurological deficits suggest disease progression to the brain. We present a patient with MCC whose seizure was not elicited by a cerebral metastasis, but by bone metastases compressing the brain. Case presentation The 62-year-old female patient had a history of CLL. A lesion with the appearance of an atheroma was removed from the right upper arm. Histology confirmed the diagnosis of MCC. She was admitted to the neurology department with her first GM seizure. The cranial MRI/MRA showed bone metastases in the right parietal and left frontal areas, compressing the brain. Flow cytometry of CSF did not reveal metastasis of MCC or CLL. No surgery was performed, chemotherapy was continued. Conclusions The case history of the patient was unique even among the rare cases of MCC with neurological involvement. The seizure was not elicited by a cerebral metastasis, but by bone metastases compressing the brain. In addition to patient history, clinical presentation and radiological findings enabled a suspected diagnosis preceding confirmation by laboratory methods.

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drawing//digital//data

Biologically-Inspired Computing for the Arts ◽

10.4018/978-1-4666-0942-6.ch019 ◽

2012 ◽

pp. 337-355 ◽

Cited By ~ 1

Author(s):

Deborah Harty

Keyword(s):

Personal Experience ◽

Specific Activity ◽

Phenomenological Approach ◽

Fine Art ◽

Swimming Pool ◽

Human Interaction ◽

Digital Data ◽

Theoretical Research ◽

Tablet Computer ◽

Apple Ipad

In the context of contemporary fine art, the chapter discusses the translation (the finding of equivalences) of a phenomenological experience of water during the activity of swimming repetitive strokes in a swimming pool into drawing with both traditional drawing media and a tablet computer – an Apple iPad. Firstly, through the identification of various physical and psychological elements that appear to consciousness whilst swimming repetitive strokes, the chapter furthers understanding and gives insights into human interaction and relationship with water during this specific activity. Secondly, the research uses the data collected from personal experience of this activity in order to explore and discuss the premise that drawing is phenomenology, considering whether this premise is compromised when drawing with an Apple iPad rather than traditional drawing media. The text considers the phenomenological approach to the research through an engagement with both philosophy (including Merleau-Ponty 1964, 2002, 2004) and theoretical research (including Rosand 2002), to underpin and generate understanding of experiences of water during the activity of swimming and the process of translation of those experiences into drawing.

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Major rise of a chronic lymphoid leukemia clone during the course of COVID‐19

International Journal of Laboratory Hematology ◽

10.1111/ijlh.13383 ◽

2020 ◽

Author(s):

Laetitia Largeaud ◽

Agnès Ribes ◽

Frédérique Dubois‐Galopin ◽

Vincent Mémier ◽

Yves Rolland ◽

...

Keyword(s):

Lymphoid Leukemia ◽

Chronic Lymphoid Leukemia

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Epileptic Seizure Provoked by Bone Metastasis of Chronic Lymphoid Leukemia and Merkel Cell Carcinoma

Case Reports in Medicine ◽

10.1155/2020/4318638 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

András Folyovich ◽

Angéla Majoros ◽

Tamás Jarecsny ◽

Gitta Pánczél ◽

Zsuzsanna Pápai ◽

...

Keyword(s):

Bone Metastases ◽

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Cerebral Metastasis ◽

Merkel Cell ◽

Lymphoid Leukemia ◽

Chronic Lymphoid Leukemia ◽

History Of ◽

The Right ◽

The Brain

Background. Merkel cell carcinoma (MCC) is a rare primary neuroendocrine cutaneous tumor, rarely metastasizing to the brain. Chronic lymphoid leukemia (CLL) is a disease predisposing to MCC. According to previous reports, headache and focal neurological deficits suggest disease progression to the brain. We present a patient with MCC whose seizure was not elicited by a cerebral metastasis, but by bone metastases compressing the brain. Case Presentation. A 62-year-old female patient had a history of CLL. A lesion with the appearance of an atheroma was removed from the right upper arm. Histology confirmed the diagnosis of MCC. She was admitted to the neurology department with her first GM seizure. The cranial MRI/MRA showed bone metastases in the right parietal and both frontal areas, compressing the brain. Flow cytometry of CSF did not reveal metastasis of MCC. Conclusions. The case history of the patient was unique even among the rare cases of MCC with neurological involvement. The seizure was not elicited by a cerebral metastasis, but by bone metastases compressing the brain. In addition to patient history, clinical presentation and radiological findings enabled a suspected diagnosis of skull metastasis of MCC compressing the brain, causing symptomatic epileptic seizures.

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