Quantitative assessment of intravenous regional limb perfusion of tiludronate as an adjunctive treatment for lameness caused by navicular syndrome in horses

2018 ◽  
Vol 79 (12) ◽  
pp. 1313-1320 ◽  
Author(s):  
Mike J. Schoonover ◽  
Chase T. Whitfield ◽  
Jenna M. Young ◽  
Kate M. Sippel ◽  
Mark E. Payton
Keyword(s):  
Quantitative Assessment ◽  
Adjunctive Treatment ◽  
Limb Perfusion ◽  
Navicular Syndrome

Quantitative assessment of peripheral limb perfusion using a modified distal arterial cannula in venoarterial ECMO settings

Perfusion ◽  
2019 ◽  
Vol 34 (6) ◽  
pp. 503-507
Author(s):  
Maik Foltan ◽  
Alois Philipp ◽  
Laszlo Göbölös ◽  
Andreas Holzamer ◽  
Roland Schneckenpointner ◽  
...  
Keyword(s):  
Blood Flow ◽  
Quantitative Assessment ◽  
Limb Ischaemia ◽  
The Novel ◽  
Venoarterial Extracorporeal Membrane Oxygenation ◽  
Arterial Cannula ◽  
Limb Perfusion ◽  
Distal Perfusion ◽  
First Time ◽  
Ecmo Flow

In cases of severe cardiopulmonary deterioration, quick establishment of venoarterial extracorporeal membrane oxygenation (ECMO) represents a support modality. After successful arterial peripheral cannulation, a certain grade of peripheral limb malperfusion is a fairly common phenomenon. Detection of peripheral malperfusion is vital, since it can result in compartment syndrome or even loss of the affected limb. To prevent or resolve emerging lower limb ischaemia, a newly designed perfusion catheter is placed into the superficial femoral artery, distal to the arterial cannula via ECMO. The aim of our study was to evaluate flow and haemodynamic characteristics of this novel distal limb perfusion cannula for ECMO therapy and present these important findings for the first time. The distal perfusion cannula blood flow increases in linear correlation with ECMO blood flow The variability of distal perfusion cannula blood flow with a 15 Fr cannula ranges between 160 ± 0.40 mL min−1 at 1.5 L min−1 ECMO flow rate and 480 ± 80 mL min−1 at 5.0 L min−1 ECMO blood flow, respectively. Comparatively, the 17-Fr-sized cannula performs on a scale of 140 ± 20 to 390 ± 60 mL distal perfusion cannula blood flow at 1.5-5.0 L min−1 ECMO blood flow, respectively. The quantitative assessment of the distal perfusion cannula blood flow has revealed that distal perfusion cannula blood flow can measure up to 10% of the ECMO blood flow. Furthermore, it has been also well demonstrated that the novel distal perfusion cannula is sufficient to compensate peripheral limb ischaemia.

Quantitative assessment of two methods of tiludronate administration for the treatment of lameness caused by navicular syndrome in horses

2016 ◽  
Vol 77 (2) ◽  
pp. 167-173 ◽  
Author(s):  
Chase T. Whitfield ◽  
Mike J. Schoonover ◽  
Todd C. Holbrook ◽  
Mark E. Payton ◽  
Kate M. Sippel
Keyword(s):  
Quantitative Assessment ◽  
Navicular Syndrome

Author response for "Quantitative assessment of amygdala in macaca fascicularis monkeys"

2020 ◽  
Author(s):  
José‐Carlos Delgado‐González ◽  
Carlos‐de‐la Rosa Prieto ◽  
Nuria Vallejo‐Calcerrada ◽  
Diana‐Lucía Tarruela‐Hernández ◽  
Sandra Cebada‐Sánchez ◽  
...  
Keyword(s):  
Quantitative Assessment ◽  
Macaca Fascicularis ◽  
Author Response

Initial experience with a new quantitative assessment tool for fluorescent imaging in peripheral artery disease

VASA ◽  
2017 ◽  
Vol 46 (5) ◽  
pp. 383-388 ◽  
Author(s):  
Henrik Christian Rieß ◽  
Anna Duprée ◽  
Christian-Alexander Behrendt ◽  
Tilo Kölbel ◽  
Eike Sebastian Debus ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Quantitative Assessment ◽  
Tissue Perfusion ◽  
Fluorescent Imaging ◽  
Peripheral Artery ◽  
Peripheral Bypass ◽  
Before And After ◽  
Artery Disease ◽  
Green Fluorescent ◽  
Peripheral Bypass Grafting

Abstract. Background: Perioperative evaluation in peripheral artery disease (PAD) by common vascular diagnostic tools is limited by open wounds, medial calcinosis or an altered collateral supply of the foot. Indocyanine green fluorescent imaging (ICG-FI) has recently been introduced as an alternative tool, but so far a standardized quantitative assessment of tissue perfusion in vascular surgery has not been performed for this purpose. The aim of this feasibility study was to investigate a new software for quantitative assessment of tissue perfusion in patients with PAD using indocyanine green fluorescent imaging (ICG-FI) before and after peripheral bypass grafting. Patients and methods: Indocyanine green fluorescent imaging was performed in seven patients using the SPY Elite system before and after peripheral bypass grafting for PAD (Rutherford III-VI). Visual and quantitative evaluation of tissue perfusion was assessed in an area of low perfusion (ALP) and high perfusion (AHP), each by three independent investigators. Data assessment was performed offline using a specially customized software package (Institute for Laser Technology, University Ulm, GmbH). Slope of fluorescent intensity (SFI) was measured as time-intensity curves. Values were compared to ankle-brachial index (ABI), slope of oscillation (SOO), and time to peak (TTP) obtained from photoplethysmography (PPG). Results: All measurements before and after surgery were successfully performed, showing that ABI, TTP, and SOO increased significantly compared to preoperative values, all being statistically significant (P < 0.05), except for TTP (p = 0.061). Further, SFI increased significantly in both ALP and AHP (P < 0.05) and correlated considerably with ABI, TTP, and SOO (P < 0.05). Conclusions: In addition to ABI and slope of oscillation (SOO), the ICG-FI technique allows visual assessment in combination with quantitative assessment of tissue perfusion in patients with PAD. Ratios related to different perfusion patterns and SFI seem to be useful tools to reduce factors disturbing ICG-FI measurements.

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