Persistent infection with bovine viral diarrhea virus in an alpaca

2006 ◽  
Vol 228 (11) ◽  
pp. 1762-1765 ◽  
Author(s):  
Donald E. Mattson ◽  
Rocky J. Baker ◽  
Jacquelynne E. Catania ◽  
Sheila R. Imbur ◽  
Kevin M. Wellejus ◽  
...  
Keyword(s):  
Bovine Viral Diarrhea Virus ◽  
Persistent Infection ◽  
Bovine Viral Diarrhea ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Viral Diarrhea Virus

scholarly journals The double-stranded RNA-induced apoptosis pathway is involved in the cytopathogenicity of cytopathogenic Bovine viral diarrhea virus

2006 ◽  
Vol 87 (10) ◽  
pp. 2961-2970 ◽  
Author(s):  
Daisuke Yamane ◽  
Kentaro Kato ◽  
Yukinobu Tohya ◽  
Hiroomi Akashi
Keyword(s):  
Cell Death ◽  
Bovine Viral Diarrhea Virus ◽  
Persistent Infection ◽  
Yield Potential ◽  
Bovine Viral Diarrhea ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Induction Of Apoptosis ◽  
Induced Apoptosis ◽  
Viral Diarrhea Virus

Bovine viral diarrhea virus (BVDV), which is classified in the genus Pestivirus, family Flaviviridae, can be divided into two biotypes according to its ability to induce a cytopathic effect in tissue culture cells. The mechanisms through which cytopathogenic (cp) BVDV induces cell death and non-cytopathogenic (ncp) BVDV causes persistent infection without producing cell death remain unclear. Here, it was found that the overexpression of four apoptosis-related cellular mRNAs in cells infected with cpBVDV could also be caused by synthetic dsRNA. In fact, it was found that the amount of dsRNA produced by cpBVDV considerably exceeded the amount yielded by ncpBVDV. To evaluate the possible involvement of dsRNA in the induction of apoptosis, this study examined whether RNAi-mediated depletion of two dsRNA-reactive cellular factors, dsRNA-dependent protein kinase and 2′,5′-oligoadenylate synthetase 1, resulted in the prevention of cpBVDV-induced apoptosis. Although the induction of apoptosis was reduced after the suppression of either factor alone, the simultaneous silencing of both factors resulted in an almost complete inhibition of apoptosis without affecting viral titre. These results showed that dsRNA is the main trigger of apoptosis in cpBVDV-infected cells and that the cytopathogenicity of BVDV depends on the yield potential of dsRNA. In contrast, ncpBVDV yielded minimal levels of dsRNA, thereby establishing a persistent infection without inducing apoptosis. This report supports the significance of viral dsRNA as a trigger of innate immune responses.

Persistent infection of American bison (Bison bison) with bovine viral diarrhea virus and bosavirus

2021 ◽  
Vol 252 ◽  
pp. 108949
Author(s):  
Ben M. Hause ◽  
Angela Pillatzki ◽  
Travis Clement ◽  
Tom Bragg ◽  
Julia Ridpath ◽  
...  
Keyword(s):  
Bovine Viral Diarrhea Virus ◽  
Persistent Infection ◽  
Bison Bison ◽  
Bovine Viral Diarrhea ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Viral Diarrhea Virus

Induction of interferon-gamma and downstream pathways during establishment of fetal persistent infection with bovine viral diarrhea virus

2014 ◽  
Vol 183 ◽  
pp. 95-106 ◽  
Author(s):  
Natalia P. Smirnova ◽  
Brett T. Webb ◽  
Jodi L. McGill ◽  
Robert G. Schaut ◽  
Helle Bielefeldt-Ohmann ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Bovine Viral Diarrhea Virus ◽  
Persistent Infection ◽  
Bovine Viral Diarrhea ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Viral Diarrhea Virus

scholarly journals Maternal and Fetal Response to Fetal Persistent Infection with Bovine Viral Diarrhea Virus*

2010 ◽  
Vol 64 (4) ◽  
pp. 295-306 ◽  
Author(s):  
Thomas R. Hansen ◽  
Natalia P. Smirnova ◽  
Hana Van Campen ◽  
Megan L. Shoemaker ◽  
Andrey A. Ptitsyn ◽  
...  
Keyword(s):  
Bovine Viral Diarrhea Virus ◽  
Persistent Infection ◽  
Bovine Viral Diarrhea ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Viral Diarrhea Virus ◽  
Fetal Response
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