Volume Quantification of Endolymph after Intravenous Administration of a Single Dose of Gadolinium Contrast Agent: Comparison of 18- versus 8-minute Imaging Protocols

Enhancement of the subarachnoid space after intravenous administration of gadolinium contrast agent is not common. Enhancement usually occurs in pathological conditions that increase the permeability of the blood–cerebrospinal fluid barrier, most notably in meningitis. We herein describe possible subarachnoid enhancement in patients with no apparent effect on the meninges. These patients had clinical signs of Meniere’s disease and underwent specific magnetic resonance imaging of the inner ear to possibly visualize endolymphatic hydrops. The endolymphatic space can be noninvasively imaged by intravenous administration of contrast agent, usually at a double dose, 4 hours before the scanning process. During this time, the contrast agent penetrates not only the perilymph but also the subarachnoid space, where the highest concentration occurs after 4 hours according to some studies.

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Brain imaging in methamphetamine-treated mice using a nitroxide contrast agent for EPR imaging of the redox status and a gadolinium contrast agent for MRI observation of blood–brain barrier function

Free Radical Research ◽

10.3109/10715762.2015.1040787 ◽

2015 ◽

Vol 49 (8) ◽

pp. 1-10 ◽

Cited By ~ 12

Author(s):

M. C. Emoto ◽

M. Yamato ◽

H. Sato-Akaba ◽

K. Yamada ◽

Y. Matsuoka ◽

...

Keyword(s):

Contrast Agent ◽

Brain Imaging ◽

Blood Brain Barrier ◽

Barrier Function ◽

Redox Status ◽

Brain Barrier ◽

Gadolinium Contrast ◽

Gadolinium Contrast Agent ◽

Blood Brain

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Simple Estimation of the Endolymphatic Volume Ratio after Intravenous Administration of a Single-dose of Gadolinium Contrast

Magnetic Resonance in Medical Sciences ◽

10.2463/mrms.mp.2015-0175 ◽

2016 ◽

Vol 15 (4) ◽

pp. 379-385 ◽

Cited By ~ 6

Author(s):

Shinji NAGANAWA ◽

Mai KANOU ◽

Toshio OHASHI ◽

Kayao KUNO ◽

Michihiko SONE

Keyword(s):

Single Dose ◽

Intravenous Administration ◽

Volume Ratio ◽

Gadolinium Contrast ◽

Simple Estimation

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Gadolinium contrast agent is of limited value for magnetic resonance imaging assessment of synovial hypertrophy in hemophiliacs

Acta Radiologica ◽

10.1080/02841850701280775 ◽

2007 ◽

Vol 48 (5) ◽

pp. 520-530 ◽

Cited By ~ 14

Author(s):

B. Lundin ◽

E. Berntorp ◽

H. Pettersson ◽

R. Wirestam ◽

K. Jonsson ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Contrast Agent ◽

Dynamic Mri ◽

Time Interval ◽

Resonance Imaging ◽

Mri Findings ◽

Gadolinium Contrast ◽

Synovial Hypertrophy ◽

Gadolinium Contrast Agent

Purpose: To examine the influence of different doses of gadolinium contrast agent on synovial enhancement, to compare magnetic resonance imaging (MRI) findings of synovial hypertrophy and radiographic joint changes in hemophiliacs, and to investigate the value of gadolinium in MRI assessment of synovial hypertrophy in hemophiliacs using dynamic MRI and MRI scoring. Material and Methods: Twenty-one hemophiliacs on prophylactic factor treatment without recent bleeds were subjected to radiography and gadolinium contrast-enhanced dynamic and static MRI of the knee using a standard dose of 0.1 mmol/kg b.w. gadoteridol. In 17 of the patients, the MRI procedure was repeated after a triple dose of gadoteridol. Results: MRI findings of synovial hypertrophy were significantly correlated with Pettersson radiographic scores. In 19 of the 21 MRI investigated joints, administration of contrast agent did not alter the result of the evaluation of synovial hypertrophy. Conclusion: The optimal time interval for volume assessment of synovial hypertrophy after injection of gadolinium contrast agent is dose dependent. Hemophiliacs without recent bleeds have minor to abundant synovial hypertrophy in joints with pronounced radiographic changes. Dynamic MRI is not useful for evaluating hemophilic arthropathy, and gadolinium contrast agent is not routinely indicated for MRI scoring of joints in hemophiliacs.

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