Organ Preservation Surgery in Patients with Relapsed Advanced Laryngeal Cancer

2020 ◽  
Vol 71 (2) ◽  
pp. 198-198
Author(s):  
Y. Sato
Keyword(s):  
Laryngeal Cancer ◽  
Organ Preservation

Phase II organ-preservation trial: Concurrent cisplatin and radiotherapy for advanced laryngeal cancer after response to docetaxel, cisplatin, and 5-fluorouracil-based induction chemotherapy

Head & Neck ◽  
2016 ◽  
Vol 39 (2) ◽  
pp. 227-233 ◽  
Author(s):  
Aron Popovtzer ◽  
Hanna Burnstein ◽  
Salomon Stemmer ◽  
Dror Limon ◽  
Ohad Hili ◽  
...  
Keyword(s):  
Induction Chemotherapy ◽  
Phase Ii ◽  
Laryngeal Cancer ◽  
Organ Preservation

scholarly journals Organ Preservation Protocols in T4 Laryngeal Cancer: a Review of the Literature

2018 ◽  
Vol 10 (1) ◽  
pp. 149-155 ◽  
Author(s):  
Narayana Subramaniam ◽  
Deepak Balasubramanian ◽  
Rithvik Reddy ◽  
Krishnakumar Thankappan ◽  
Subramania Iyer
Keyword(s):  
Laryngeal Cancer ◽  
Organ Preservation ◽  
Review Of The Literature

Laryngeal biopsies: are we doing more, and why? A decade of results

2015 ◽  
Vol 130 (1) ◽  
pp. 100-103 ◽  
Author(s):  
S Lim ◽  
P Sau ◽  
L Cooper ◽  
A McPhaden ◽  
K MacKenzie
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Laryngeal Cancer ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Early Stage ◽  
Benign Disease ◽  
Advanced Head ◽  
Benign Pathology ◽  
Histopathological Results

AbstractBackground:Over the last decade, we have observed an escalating trend in the number of laryngeal biopsies performed, despite the incidence of laryngeal cancer remaining constant. This study aimed to quantify the rate of laryngeal biopsies and record the indications.Method:A retrospective analysis of laryngeal biopsies performed in North Glasgow, Scotland, UK, between 2001 and 2010, was conducted.Results:From 2001 to 2010, 3902 laryngeal biopsies were carried out in North Glasgow. Histopathological results indicated the following diagnoses: squamous cell carcinoma, in 889 cases (23 per cent); dysplasia, in 986 cases (25 per cent); ‘no tumour’, in 913 cases (23 per cent); and benign pathology, in the remaining 1084 cases (28 per cent). There has been a significant increase in the number of biopsies performed after 2004, with the incidence of squamous cell carcinoma and benign disease remaining relatively static.Conclusion:It is hypothesised that organ preservation strategies, endoscopic resection in early stage laryngeal cancer and chemoradiotherapy in advanced head and neck cancer are responsible for the increase in laryngeal biopsies.

scholarly journals Chemotherapy alone for organ preservation in advanced laryngeal cancer

Head & Neck ◽  
2009 ◽  
Vol 32 (8) ◽  
pp. 1040-1047 ◽  
Author(s):  
Vasu Divi ◽  
Francis P. Worden ◽  
Mark E. Prince ◽  
Avraham Eisbruch ◽  
Julia S. Lee ◽  
...  
Keyword(s):  
Laryngeal Cancer ◽  
Organ Preservation

Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer

2003 ◽  
Vol 349 (22) ◽  
pp. 2091-2098 ◽  
Author(s):  
Arlene A. Forastiere ◽  
Helmuth Goepfert ◽  
Moshe Maor ◽  
Thomas F. Pajak ◽  
Randal Weber ◽  
...  
Keyword(s):  
Laryngeal Cancer ◽  
Organ Preservation ◽  
Concurrent Chemotherapy

Organ Preservation With Concurrent Chemoradiation for Advanced Laryngeal Cancer: Are We Succeeding?

2010 ◽  
Vol 76 (2) ◽  
pp. 398-402 ◽  
Author(s):  
Louise Lambert ◽  
Bernard Fortin ◽  
Denis Soulières ◽  
Louis Guertin ◽  
Geneviève Coulombe ◽  
...  
Keyword(s):  
Laryngeal Cancer ◽  
Organ Preservation ◽  
Concurrent Chemoradiation

scholarly journals Functional Organ Preservation for Laryngeal Cancer: Past, Present and Future

2012 ◽  
Vol 42 (3) ◽  
pp. 155-160 ◽  
Author(s):  
M. Nakayama ◽  
O. Laccourreye ◽  
F. C. Holsinger ◽  
M. Okamoto ◽  
K. Hayakawa
Keyword(s):  
Laryngeal Cancer ◽  
Organ Preservation

Factors Predictive of Poor Functional Outcome after Chemoradiation for Advanced Laryngeal Cancer

2002 ◽  
Vol 127 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Jonathan Staton ◽  
K. Thomas Robbins ◽  
Lisa Newman ◽  
Sandeep Samant ◽  
Merry Sebelik ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Functional Outcome ◽  
Vocal Cord ◽  
Laryngeal Cancer ◽  
Organ Preservation ◽  
Tertiary Care ◽  
Feeding Tube ◽  
Gastrostomy Tube ◽  
Poor Functional Outcome ◽  
Laryngeal Function

OBJECTIVE: The study goal was to determine whether pretreatment parameters can be used to predict poor outcomes related to laryngeal function among survivors after organ preservation therapy for advanced laryngeal cancer. DESIGN: A retrospective analysis of patients treated in an ongoing chemoradiation trial. SETTING: Academic tertiary care referral medical center. PATIENTS AND METHODS: Among the 65 patients receiving concomitant intra-arterial cisplatin and radiation therapy for stage III and IV laryngeal cancer between 1993 and 1999, we identified 45 who were available for follow-up and were disease free 6 months after the completion of therapy. A nominal logistic regression analysis was performed to study the effect of age, gender, T and N classification, vocal cord fixation, massive cartilage destruction, and neck dissection on the likelihood of requiring a tracheostomy tube for breathing and/or a gastrostomy tube for feeding at 6 months after the completion of therapy. MAIN OUTCOME MEASURE: Persistent use of gastrostomy tube feedings and/or tracheostomy at 6 months after the completion of therapy. RESULTS: Sixteen patients (36%) required a feeding tube and/or a tracheostomy (tracheostomy 13, gastrostomy 13, both 10). Regression analysis of all pretreatment factors indicated vocal cord fixation as being the strongest predictor of a poor functional outcome (defined as the persistent need for a feeding tube and/or tracheostomy at 6 months after therapy). Among the 27 patients in this subset, 15 (56%) had a poor functional outcome. In contrast, only 1 (6%) of 18 patients without vocal cord fixation had poor laryngeal function. Although the history of pulmonary disease was not a significant parameter by itself, when combined with vocal cord fixation, 6 of 8 patients had a poor functional outcome. CONCLUSION: Pretreatment parameters may be used to predict a poor functional outcome after chemoradiation. Because of the high likelihood of poor function, laryngeal cancer patients seeking organ preservation therapy with chemoradiation should be cautioned if they present with a fixed vocal cord.

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