Eye diseases associated with obstructive sleep apnea syndrome in an Asian population

Abstract Background: Sleep apnea syndrome is one of the leading causes of excessive daytime sleepiness. There is no literature exploring the prevalence of sleep-associated disorders in the eye of Asians with obstructive sleep apnea syndrome (OSA). Objective: Study the prevalence of eye abnormalities in Asian patients with OSA. Material and method: Asian patients with definite OSA diagnosis via the polysomnography were recruited into the study. Complete eye examination and special investigations were performed to define eye diseases: floppy eyelids, dry eyes, keratoconus, Fuchs’ endothelial dystrophy, recurrent corneal erosions, open-angle glaucoma, ophthalmoplegia, papilledema and optic neuropathy. Results: One-hundred Asian OSA patients were examined. We found that floppy eyelids, dry eyes, and normal tension glaucoma were more prevalent compared to the normal population. Abnormal endothelial change and papilledema were detected. Optic neuropathy and ophthalmoplegia were not found in this study, although some patients did have subnormal contrast sensitivity. Conclusion: There is a higher prevalence of floppy eyelids, dry eyes, and glaucoma in OSA patients. Complete eye examination is recommended in OSA patients to detect early eye abnormalities.

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Early Corneal and Optic Nerve Changes In Paediatric Population Affected By Obstructive Sleep Apnea Syndrome

10.21203/rs.3.rs-522563/v1 ◽

2021 ◽

Author(s):

Erika Bonacci ◽

Adriano Fasolo ◽

Marco Zaffanello ◽

Tommaso Merz ◽

Giacomo Brocoli ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Optic Nerve ◽

Obstructive Sleep Apnea Syndrome ◽

Corneal Thickness ◽

Sleep Apnea Syndrome ◽

Fiber Layer ◽

Obstructive Sleep ◽

Eye Examination ◽

Apnea Syndrome

Abstract PURPOSE: The relation between OSAS and eye diseases is well-known in adults, while very few and contradictory data can be found regarding paediatric ages. The aim of this study is to explore the early corneal, macular and optic nerve changes in paediatric patients with OSAS. METHODS: prospective study that enrolled children aged ≥ 4 years referred to the Paediatric Pneumology Clinic in Verona for suspected obstructive sleep apnea syndrome (OSAS) and investigated with the overnight respiratory polygraphy. Patients with apnea-hypopnea index (AHI)>1 were classified as OSAS, those with AHI<1 were classified non-OSAS. All patients underwent comprehensive eye examination including slit lamp, refraction, intraocular pression (Goldman applanation tonometry), corneal tomography (corneal astigmatism, corneal keratometry at the apex, Surface Asymmetry Index, Central corneal Thickness and Thinnest corneal Thickness), optical coherence tomography (central macular thickness, macular volume, and retinal nerve fiber layer).RESULTS: 72 children were enrolled in the study. The overall prevalence of OSAS was 48.6%. Statistically significant differences were found between OSAS and non-OSAS group for corneal asymmetry (0.9 ± 0.5 and 0.6 ±0.3, respectively; p=0.02), thinnest corneal thickness (551.8 ± 33.9 and 563.7 ±32.5; p= 0.04), average retinal nerve fiber layer (102.8 µm ± 10.5 and 98.1 µm ±12.3; p=0.012) and in nasal quadrant (76.2±15.4 µm and 66.5 ±12.6 µm; p= 0.0002).CONCLUSIONS: comprehensive eye examination with corneal and optic nerve imaging showed early corneal and optic nerve changes in children newly diagnosed with OSAS. These could be prelude of the known ocular manifestations associated with OSAS in adult patients.

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CHRONIC TONSILLITIS AND ITS SIGNIFICANCE IN PATIENTS WITH SNORING AND OBSTRUCTIVE SLEEP APNEA SYNDROME

10.33848/foliorl23103825-2019-25-2-11-19 ◽

2019 ◽

Vol 25 (2) ◽

pp. 11-19

Author(s):

A.A. Blotsky ◽

◽

V.V. Antipenko ◽

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Obstructive Sleep Apnea Syndrome ◽

Sleep Apnea Syndrome ◽

Chronic Tonsillitis ◽

Obstructive Sleep ◽

Apnea Syndrome

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Postoperative monitoring of children with obstructive sleep apnea syndrome

Orvosi Hetilap ◽

10.1556/oh.2014.29879 ◽

2014 ◽

Vol 155 (18) ◽

pp. 703-707 ◽

Cited By ~ 1

Author(s):

Pálma Benedek ◽

Gabriella Kiss ◽

Eszter Csábi ◽

Gábor Katona

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Obstructive Sleep Apnea Syndrome ◽

Preoperative Evaluation ◽

Sleep Apnea Syndrome ◽

Study Patient ◽

Severe Obstructive Sleep Apnea ◽

Obstructive Sleep ◽

Significant Difference ◽

Apnea Syndrome

Introduction: Treatment of pediatric obstructive sleep apnea syndrome is surgical. The incidence of postoperative respiratory complications in this population is 5–25%. Aim: The aim of the authors was to present the preoperative evaluation and monitoring procedure elaborated in Heim Pál Children Hospital, Budapest. Method: 142 patients were involved in the study. Patient history was obtained and physical examination was performed in all cases. Thereafter, polysomnography was carried out, the severity of the obstructive sleep apnea syndrome was determined, and the patients underwent tonsilloadenotomy. Results: 45 patients with mild, 50 patients with moderate and 47 patients with severe obstructive sleep apnea syndrome were diagnosed. There was no complication in patients with mild disease, while complications were observed in 6 patients in the moderate group and 24 patients in the severe group (desaturation, apnea, stridor, stop breathing) (p<0.000). In patients with severe obstructive sleep apnea syndrome, no significant difference was noted in preoperative apnoea-hypapnea index (p = 0.23) and in nadir oxygen saturation values (p = 0.73) between patients with and without complication. Conclusions: Patients with severe obstructive sleep apnea syndrome should be treated in hospital where pediatric intensive care unit is available. Orv. Hetil., 2014, 155(18), 703–707.

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