Characteristics of unintentional ingestion of oral non-steroidal anti-inflammatory drugs and analgesics in preschool children

Abstract We characterised accidental ingestion of non-steroidal anti-inflammatory drugs and non-opioid analgesics in children aged 0–5 years between 2009 and 2019 by analysing records of telephone consultations with the Croatian Poison Control Centre (CPCC) and cases treated at the Children’s Hospital Zagreb (CHZ). Among the total of 466 identified cases (411 from CPPCC records and 55 from CHS hospital records), the most frequently ingested drugs were ibuprofen (47 %), paracetamol (20 %), ketoprofen (15 %), and diclofenac (11 %). In 94 % of the cases unsupervised children ingested the drug left within their reach. The remaining 6 % were dosing errors by parents or caregivers and involved liquid formulations as a rule. Our findings can serve as real-life examples informing preventive measures.

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Short-term Experience of the Newly Established Poison Control Centre of Cairo

Human Toxicology ◽

10.1177/096032718300200225 ◽

1983 ◽

Vol 2 (2) ◽

pp. 327-334 ◽

Cited By ~ 1

Author(s):

Bahira A. Fahim ◽

Laila M. El-Semary

Keyword(s):

Attempted Suicide ◽

Preventive Measures ◽

Accidental Poisoning ◽

Poison Control ◽

Short Term ◽

Early Experiences ◽

Control Centre ◽

Poison Control Centre ◽

Children Under 5

1 During the first 31 weeks of operation, the Cairo Poison Control Centre received 463 enquiries. 2 Accidental poisoning predominated with 54% of cases involving children under 5 years of age whilst attempted suicide was reported in only 21 %. 3 When these early experiences are compared with the observations from the European Poison Control Centres, there are a number of marked differences including the types of drugs and chemicals involved. 4 Problems associated with drugs considered obsolete in Europe, inadequately labelled chemicals and inappropriate treatments have already been highlighted, and preventive measures are being considered.

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Toxic surveillance using poison control centre data-stream

Toxicology Letters ◽

10.1016/j.toxlet.2010.03.026 ◽

2010 ◽

Vol 196 ◽

pp. S2 ◽

Cited By ~ 1

Author(s):

S. Ballesteros ◽

M. Martínez-Arrieta ◽

M. Ramón

Keyword(s):

Data Stream ◽

Poison Control ◽

Control Centre ◽

Poison Control Centre

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Comparative analysis of different methods of anesthesia in patients with acute pancreatitis using pain scales

Kazan medical journal ◽

10.17750/kmj2016-217 ◽

2016 ◽

Vol 97 (2) ◽

pp. 217-221

Author(s):

V N Shilenok ◽

E V Nikitina

Keyword(s):

Acute Pancreatitis ◽

Comparative Analysis ◽

Visual Analogue Scale ◽

Pain Intensity ◽

Epidural Anesthesia ◽

Analogue Scale ◽

Pain Syndrome ◽

Opioid Analgesics ◽

Inflammatory Drugs ◽

Anti Inflammatory

Aim. To conduct a comparative analysis of used anesthesia methods in patients with acute pancreatitis in intensive care units settings using pain scales.Methods. Depending on the anesthesia type, 44 patients with acute pancreatitis were divided into three groups: the first group received intramuscular injections of nonsteroidal anti-inflammatory drugs and spasmolytics, the second group - intramuscular injections of non-steroidal anti-inflammatory drugs and opioid analgesics, the third group - epidural anesthesia with local anesthetics. Comparative analysis of pain character, intensity was conducted, its dynamics in patients of all groups amid anesthesia was evaluated using a visual analogue scale, verbal rating scale, verbal descriptor scale, McGill pain questionnaire.Results. Baseline pain intensity in patients of all groups was high. Patients estimated this pain as «very strong». The time and the level of pain intensity reduction for various anesthesia types had differences. Pain syndrome was eliminated slower in patients of the second group. By the end of the 1st day, patients of this group continued to complain of «strong» pain. Pain intensity decreased only on the 2nd day - patients reported «moderate» pain. Pain syndrome was not completely eliminated in these patients for 2 days of anesthesia. 97.7% of patients reported that the visual analogue scale is the most acceptable pain assessment scale for them.Conclusion. In patients with acute pancreatitis, the most optimal anesthesia types are intramuscular nonsteroidal anti-inflammatory drugs with spasmolytics and prolonged epidural anesthesia with local anesthetics; intramuscular administration of opioid analgesics with non-steroidal anti-inflammatory drugs is less effective in relieving pain.

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