scholarly journals Efficiency of Executive Functions and Literacy Among Children With Specific Language Impairment

2018 ◽  
Vol 22 (1) ◽  
pp. 307-327
Author(s):  
Izabela Kaczmarek ◽  
Sławomir Jabłoński ◽  
Paweł Kleka ◽  
Barbara Steinborn

Abstract Recently, extensive studies investigating executive functions in children with specific language impairment (SLI) have been performed. In the present study, we compared the level of executive functions (i.e., inhibitory control and cognitive flexibility) and literacy skills between 53 healthy children and 53 children with SLIs between the ages of 3 and 11 years. The groups were matched by age, gender and parental education level. Executive functions were assessed using the Children Card Sort, and the Literacy Assessment Battery was applied to measure literacy skills. The patients with SLI displayed a significantly lower level of cognitive flexibility than that of the healthy children. No significant differences were observed between the groups in inhibitory control and the majority of literacy skills. The results confirm the hypothesis that patients with SLI experience difficulties in cognitive flexibility.

2019 ◽  
Vol 22 (1) ◽  
pp. 49-56
Author(s):  
DS Minchev ◽  
NT Popov ◽  
SI Naimov ◽  
IN Minkov ◽  
TI Vachev

AbstractSpecific language impairment (SLI) is a psychiatric condition with a complex etiology and a substantial genetic basis that affects children's verbal communication abilities. In this study, we examined the expression of five different human endogenous retrovirus elements (HERVs) in a cohort of 25 children with SLI and 25 healthy children in the control group. Human endogenous retrovirus elements, a diverse group of repetitive DNA sequences, can potentially cause considerable genetic heterogeneity. They had been integrated in the genome of our ancestors throughout evolution and now consist of about 8.0% of the human genome. Several HERV loci are transcribed in various cell types. Their expression in peripheral blood and in the brain is altered in many neurological and psychiatric diseases. To date, HERV expression profiles have never been studied in patients with SLI. This study aimed to elucidate differentially regulated human endogenous retroelements in peripheral blood of children with SLI, in comparison with healthy controls, through quantitative reverse tran-scription-polymerase chain reaction (qRT-PCR) methodology. Our results show that two genes: HERV-K (HLM-2) gag and HERV-P env were expressed at lower levels in the blood samples from SLI children in comparison with those in the control group.


2017 ◽  
Vol 32 (6) ◽  
pp. 355-362 ◽  
Author(s):  
V. Acosta Rodríguez ◽  
G.M. Ramírez Santana ◽  
S. Hernández Expósito

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