Late Onset of Pancreatic Metastases from Renal Cell Carcinoma. A Case Report

AbstractMetastasis of renal cell carcinoma (RCC) to the pancreas is a rare entity accounting only 0.25–3% of all pancreatic tumors. We present a rare case of isolated three focal pancreatic metastases from RCC, occurring 15 years after the left nephrectomy. The majority of the pancreatic metastases are asymptomatic, as it was in case of our patient excluding the weight loss for the last three months. We demonstrate the importance of the medical history, radiological examinations, histological and immunohistochemical analysis in making a definitive diagnosis.

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A rare case of spontaneous necrosis of primary renal cell carcinoma

Canadian Urological Association Journal ◽

10.5489/cuaj.2272 ◽

2015 ◽

Vol 9 (1-2) ◽

pp. 33 ◽

Cited By ~ 2

Author(s):

Kyosuke Matsuzaki ◽

Ryoichi Imamura ◽

Toshichika Iwanishi ◽

Masahiro Nakagawa ◽

Go Tanigawa ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Rare Case ◽

Left Kidney ◽

Immunohistochemical Analysis ◽

Chief Complaint ◽

Gross Hematuria ◽

Primary Renal Cell Carcinoma ◽

Abundant Cytoplasm

A 42-year-old woman was referred to our hospital with a chief complaint of asymptomatic gross hematuria. Computed tomography revealed a 4-cm tumour in the left kidney and radical nephrectomy was performed. Microscopically, the tumour was completely necrotic and consisted of nests of cells with abundant cytoplasm and large nuclei. Immunohistochemical analysis indicated complete infarction of the chromophobe renal cell carcinoma. Two years after surgery, the patient remained recurrence-free.

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A Rare Case of Multiple Pancreatic Metastases in a Patient With Renal Cell Carcinoma

The American Journal of Gastroenterology ◽

10.14309/00000434-201410002-00944 ◽

2014 ◽

Vol 109 ◽

pp. S282

Author(s):

Syed Amer ◽

Vishnu Teja Kommineni ◽

Wajeeh Salah ◽

Cuong Nguyen ◽

Rahul Pannala

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Rare Case ◽

Pancreatic Metastases

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995: Immunohistochemical Analysis of Tumor Polyamines Discriminates High Risk Patients Undergoing Nephrectomy for Renal Cell Carcinoma

The Journal of Urology ◽

10.1016/s0022-5347(18)38232-6 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 263-263

Author(s):

Nathalie Rioux-Leclercq ◽

Florence Jouan ◽

Pascale Bellaud ◽

Jacques-Philippe Moulinoux ◽

Karim Bensalah ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

High Risk ◽

Cell Carcinoma ◽

Renal Cell ◽

Immunohistochemical Analysis ◽

High Risk Patients ◽

Risk Patients

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Metastatic clear cell renal cell carcinoma presenting as breast lump: A rare case report

Diagnostic Cytopathology ◽

10.1002/dc.24710 ◽

2021 ◽

Author(s):

Vikrant Verma ◽

Amrin Israrahmed ◽

Ram N. Rao

Keyword(s):

Renal Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Renal Cell ◽

Rare Case ◽

Clear Cell ◽

Breast Lump ◽

Cell Renal Cell Carcinoma ◽

Rare Case Report

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Clinicopathologic features of TDO2 overexpression in renal cell carcinoma

BMC Cancer ◽

10.1186/s12885-021-08477-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Quoc Thang Pham ◽

Daiki Taniyama ◽

Yohei Sekino ◽

Shintaro Akabane ◽

Takashi Babasaki ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

In Silico Analysis ◽

Immunohistochemical Analysis ◽

Rna Seq ◽

Anoikis Resistance ◽

Silico Analysis ◽

Proliferation And Invasion

Abstract Background Tryptophan 2,3-dioxygenase (TDO2) is the primary enzyme catabolizing tryptophan. Several lines of evidence revealed that overexpression of TDO2 is involved in anoikis resistance, spheroid formation, proliferation, and invasion and correlates with poor prognosis in some cancers. The aim of this research was to uncover the expression and biofunction of TDO2 in renal cell carcinoma (RCC). Methods To show the expression of TDO2 in RCC, we performed qRT-PCR and immunohistochemistry in integration with TCGA data analysis. The interaction of TDO2 with PD-L1, CD44, PTEN, and TDO2 expression was evaluated. We explored proliferation, colony formation, and invasion in RCC cells line affected by knockdown of TDO2. Results RNA-Seq and immunohistochemical analysis showed that TDO2 expression was upregulated in RCC tissues and was associated with advanced disease and poor survival of RCC patients. Furthermore, TDO2 was co-expressed with PD-L1 and CD44. In silico analysis and in vitro knockout of PTEN in RCC cell lines revealed the ability of PTEN to regulate the expression of TDO2. Knockdown of TDO2 suppressed the proliferation and invasion of RCC cells. Conclusion Our results suggest that TDO2 might have an important role in disease progression and could be a promising marker for targeted therapy in RCC. (199 words)

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Pancreatic ductal adenocarcinoma concomitant with pancreatic metastases of clear-cell renal cell carcinoma: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-021-02768-8 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Lena Haeberle ◽

Melanie Busch ◽

Julian Kirchner ◽

Georg Fluegen ◽

Gerald Antoch ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Pancreatic Ductal Adenocarcinoma ◽

Renal Cell ◽

Clear Cell ◽

Ductal Adenocarcinoma ◽

Special Role ◽

Cell Renal Cell Carcinoma ◽

Pancreatic Metastases

Abstract Background Metastatic spread to the pancreas is a rare event. Renal cell carcinoma represents one possible site of origin of pancreatic metastases. Renal cell carcinoma often metastasizes late and exclusively to the pancreas, suggesting a special role of renal cell carcinoma among primaries metastasizing to the pancreas. Even rarer, renal cell carcinoma may occur simultaneously with pancreatic ductal adenocarcinoma. Case presentation We present the case of a 78-year-old male Caucasian patient with a history of clear-cell renal cell carcinoma treated with oncological left nephrectomy 20 years before. The patient was diagnosed with pancreatic ductal adenocarcinoma by fine-needle aspiration cytology. At our institution, he received neoadjuvant therapy with folic acid, fluorouracil, irinotecan, oxaliplatin for borderline-resectable pancreatic ductal adenocarcinoma, and subsequently underwent total pancreatectomy. Upon resection, pancreatic ductal adenocarcinoma as well as two metachronous metastases of clear-cell renal cell carcinoma occurring simultaneously and cospatially with pancreatic ductal adenocarcinoma were diagnosed in the pancreatic body. Conclusions Renal cell carcinoma metastases of the pancreas are rare and often occur decades after the initial diagnosis of renal cell carcinoma. The combination of renal cell carcinoma metastases and pancreatic ductal adenocarcinoma is even rarer. However, the possibility should be considered by clinicians, radiologists, and pathologists. The special role of renal cell carcinoma as a site of origin of pancreatic metastasis should be further elucidated.

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