scholarly journals Role of vascular disorders in lung injury in patients with rheumatoid arthritis

2016 ◽  
Vol 15 (3) ◽  
pp. 15-23 ◽  
Author(s):  
I. I. Nesterovich ◽  
K. V. Nochevnaya ◽  
Y. D. Rabik ◽  
A. A. Speranskaya ◽  
V. P. Zolotnitskaya ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Computed Tomography ◽  
Lung Injury ◽  
Pulmonary Function Tests ◽  
Photon Emission ◽  
Diagnostic Methods ◽  
Control Group ◽  
Emission Computed Tomography ◽  
Vascular Disorders

Introduction. The incidence of respiratory system involvement in patients with rheumatoid arthritis (RA) has currently increased; thereby new diagnostic methods have been developed actively. Meanwhile role of vascular disorders in pathogenesis of lung injury is almost unknown and single-photon emission computed tomography (SPECT) isn't used as method of lung assessment in RA. The detector of endothelial glycocalyx damage syndecan-1 is little known but potentially perspective serum marker of lung injury in RA. Objective. The purpose of the study was to investigate the role of vascular disorders in lung injury in patients with RA. Materials and methods. 61 patients with RA without comorbid lung diseases were enrolled in the study. Control group consisted of 26 healthy persons. Patients underwent survey and physical examination, high-resolution computed tomography (HRCT) and SPECT of the lungs and pulmonary function tests (PFTs). Also serum levels of rheumatoid factor (RF), anti-cyclic citrullinated peptide antibodies (ACCP) and syndecan-1 were measured. Results. All patients developed microcirculation impairment on SPECT. Vascular disorders were according to changes of lung structure detected by HRCT (r = 0.434; p = 0.044). Areas of hypoperfusion matched with ground glass opacities, lung fibrosis, branching linear structures and airway obstruction on HRCT-SPECT fusion scans. Syndecan-1 level was higher in patients with RA compared with healthy controls (р = 0.019). Conclusion. Vascular disorders are important in pathogenesis of lung injury in RA, and SPECT has high sensitivity in lung assessment. Perfusion impairment in lungs correlates with syndecan-1 level, thus syndecan-1 could be used as marker of lung injury in RA thereafter.

The role of L-3-1-123-iodine-α-methyl tyrosine-SPECT in cerebral gliomas

2000 ◽  
Vol 39 (08) ◽  
pp. 233-240 ◽  
Author(s):  
D. Schmidt ◽  
P. Matheja ◽  
H. H. Coenen ◽  
K.-J. Langen ◽  
M. Weckesser
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Magnetic Resonance Tomography ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Cerebral Gliomas ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

SummaryL-3-1-123-iodine-a-methyltyrosine (IMT) is a 1-123-labelled amino acid which has been used for single photon emission computed tomography (SPECT) of cerebral gliomas for more than a decade. IMT-SPECT is able to detect tumor infiltration independent of disruptions of the blood-brain barrier which is often difficult with computed tomography or magnetic resonance tomography. The method is useful to detect tumor recurrences and helps to distinguish gliomas from non-neoplastic brain masses. IMT-SPECT is thus a valuable tool in the diagnostic evaluation and in therapy planning of patients with cerebral gliomas.

scholarly journals 5-HT1A-receptor agonist modified amygdala activity and amygdala-associated social behavior in a valproate-induced rat autism model

2013 ◽  
Vol 16 (9) ◽  
pp. 2027-2039 ◽  
Author(s):  
Chao-Chuan Wang ◽  
Hui-Ching Lin ◽  
Yun-Han Chan ◽  
Po-Wu Gean ◽  
Yen Kung Yang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Receptor Agonist ◽  
Tryptophan Hydroxylase ◽  
Single Photon ◽  
Photon Emission ◽  
Underlying Mechanism ◽  
Emission Computed Tomography ◽  
Memory Extinction ◽  
Amygdala Activity

Abstract Accumulating evidence suggests that dysfunction of the amygdala is related to abnormal fear processing, anxiety, and social behaviors noted in autistic spectrum disorders (ASDs). In addition, studies have shown that disrupted brain serotonin homeostasis is linked to ASD. With a valproate (VPA)-induced rat ASD model, we investigated the possible role of amygdala serotonin homeostasis in autistic phenotypes and further explored the underlying mechanism. We first discovered that the distribution of tryptophan hydroxylase immunoreactivity in the caudal raphe system was modulated on postnatal day (PD) 28 of the VPA-exposed offspring. Then, we found a significantly higher serotonin transporter availability in the amygdala of the VPA-exposed offspring on PD 56 by using single photon emission computed tomography and computed tomography co-registration following injection of 123I-labeled 2-((2-(dimethylamino)methyl)phenyl)thio)-5-iodophenylamine(123I[ADAM]). Furthermore, treatment with 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a 5-HT1A receptor agonist, increased social interaction and improved fear memory extinction in the VPA-exposed offspring. 8-OH-DPAT treatment also reversed the characteristics of miniature excitatory post-synaptic currents as well as paired pulse facilitation observed in lateral amygdala slices. These results provided further evidence to support the role of the amygdala in characteristic behavioral changes in the rat ASD model. The serotonergic projections that modulate the amygdala function might play a certain role in the development and treatment of behavioral symptoms exhibited in individuals with ASD.

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