scholarly journals The microcirculatory changes in patients with intermittent claudication after endovascular restoration of main blood flow to the extremity

2018 ◽  
Vol 17 (2) ◽  
pp. 42-48
Author(s):  
N. N. Streltsova ◽  
A. P. Vasilyev ◽  
I. S. Bessonov ◽  
G. V. Kolunin
Keyword(s):  
Blood Flow ◽  
Lower Extremity ◽  
Intermittent Claudication ◽  
Functional State ◽  
Venous Congestion ◽  
Laser Doppler ◽  
Microvascular Blood Flow ◽  
Endovascular Interventions ◽  
Pathogenic Determinant

The functional state of microvascular blood flow is the major pathogenic determinant in patients with intermittent claudication (IC). Revealing features of microcirculation (MC) shifts has been especially valuable after endovascular interventions. Purpose. To assess the alterations in MC profile after the restoration of main blood flow to affected extremity in patients with IC. Material and methods. MC was assessed by laser Doppler flowmehy in 37 patients before and 1 month after lower extremity angioplasty. Results. Restoration of main blood flow was associated with increased nutritional blood flow by 56.0 %, decreased arteriole-venule shunts by 30.7 % and venous congestion by 13.5 %. Conclusion. Endovascular interventions in patients with IC are associated with recovery of balance in MC processes.

Validation of laser-Doppler flowmetry in measurement of spinal cord blood flow

1989 ◽  
Vol 257 (2) ◽  
pp. H674-H680 ◽  
Author(s):  
P. J. Lindsberg ◽  
J. T. O'Neill ◽  
I. A. Paakkari ◽  
J. M. Hallenbeck ◽  
G. Feuerstein
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Microvascular Blood Flow ◽  
Base Line ◽  
Spinal Cord Blood Flow ◽  
Flow Measurements ◽  
Doppler Flowmetry

Laser-Doppler flowmetry (LDF) is a non-invasive method for continuous on-line monitoring of microvascular blood flow. LDF has previously been validated with established methods in various tissues, yet its validity and resolution in the central nervous system (CNS) remain unclear. We compared LDF with the microsphere method (MS) using two independent laser probes placed on the dorsal lumbar spinal cord (L5 laminectomy) of anesthetized rabbits (n = 9). After base-line flow measurements, spinal cord blood flow (SCBF) was increased (up to 50%) with phenylephrine (10-80 micrograms.kg-1.min-1 iv) and decreased (up to 50%) with chlorisondamine (10 mg/kg iv) or other stimuli. The percentage changes of lumbar SCBF and vascular resistance (VR) from the base line obtained by LDF and MS excellently agreed (rBF = 0.86, rVR = 0.94, P less than 0.0001). LDF estimated also the absolute SCBF values parallel to MS (r = 0.77, P less than 0.001). In conclusion, the validity of LDF in estimating the SCBF and dynamic changes of BF and VR is confirmed. Therefore, LDF may prove useful for monitoring CNS microcirculation in normal or pathophysiological states.

The influence of smoking on the functional state of microcirculation according to laser doppler flowmetry and clinical anamnestic data of patients with arterial hypertension

2021 ◽  
Vol 24 (4) ◽  
pp. 24-31
Author(s):  
N. N. Streltsova ◽  
A. P. Vasiliev
Keyword(s):  
Blood Flow ◽  
Arterial Hypertension ◽  
Functional State ◽  
Laser Doppler Flowmetry ◽  
Tobacco Smoke ◽  
Tobacco Smoking ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Vascular Bed ◽  
Terminal Vascular Bed

Background. Detailed study of the functional state of microcirculation in combination of arterial hypertension and tobacco smoking, as the most common and prognostically important risk factors for atherogenesis, will not only clarify pathogenetic effect of tobacco smoke on the terminal vascular bed, but also outline directions of active counteraction to it.Purpose. To study the effect of TS on the functional state of SM using laser Doppler flowmetry in patients with AH.Methods. 185 patients with stage 1,2 AH involved in the study were divided into 2 equivalent groups according to main clinical and laboratory data: group 1 – non-smokers (n = 134, mean age was 57.0 [50.0; 60.0]), group 2 – patients who smoke 1–1.5 packs of cigarettes per day (n = 51, mean age was 54.0 [48.0; 58.0]). Patients were prescribed short-acting antihypertensives drugs, which were used whenever required 5 days before the study. SM was investigated by laser Doppler flowmetry using occlusion test and amplitude-frequency spectrum analysis of hemoperfusion fluctuations.Results. Obtained data showed negative acute effect of ingredients of tobacco smoke on almost all structural elements of microhemocirculation. Revealed deviations are characterized by constriction of precapillary segment of microvascular bed with increase in myogenic tone and equal 3.1 units [2.6; 4.1] versus 2.3 units [1.7; 3.4] in the alternative group (p = 0.007), decrease in capillary blood flow from 4.5 units [3.5; 5.8] compared with the group of non-smokers – 5.2 units [4.0; 7.3] (p = 0.041), statistically significant intensification of arteriolar-venular blood flow with formation of venous congestion, limitation of dilated reserve of microcirculation.Conclusion. Tobacco smoking leads to significant microcirculation disorders that are projected onto changes in terminal vascular bed, inherent with AH, which significantly reduces the functional state of microcirculation, limits its reserve potential and promotes the development of tissue ischemia.

Microvascular Blood Flow, Volume, and Velocity Measured by Laser Doppler Techniques in IDDM

Diabetes ◽  
1989 ◽  
Vol 38 (7) ◽  
pp. 819-824 ◽  
Author(s):  
M. Rendell ◽  
T. Bergman ◽  
G. O'Donnell ◽  
E. Drobny ◽  
J. Borgos ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Doppler ◽  
Microvascular Blood Flow ◽  
Flow Volume ◽  
Blood Flow Volume ◽  
Doppler Techniques

Role of nitric oxide in vasodilator response induced by salbutamol in rat diaphragmatic microcirculation

1997 ◽  
Vol 272 (5) ◽  
pp. H2173-H2179 ◽  
Author(s):  
H. Y. Chang
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Cyclic Amp ◽  
Laser Doppler Flowmetry ◽  
Ringer Solution ◽  
Laser Doppler ◽  
Microvascular Blood Flow ◽  
Doppler Flowmetry ◽  
Vasodilator Response

To determine the contribution of nitric oxide (NO) to the vasodilator response induced by salbutamol in diaphragmatic microcirculation, we studied a diaphragmatic preparation in anesthetized rats. With bicarbonate-buffered Ringer solution continuously suffusing the diaphragm, laser-Doppler flowmetry was used to record microvascular blood flow (QLDF). The drugs were applied to the surface of the diaphragm. Salbutamol (3.2 x 10(-7)-10(-4) M), isoproterenol (3.2 x 10(-8)-3.2 x 10(-6) M), and forskolin (3.2 x 10(-7)-10(-5) M) each elicited a concentration-dependent increase in QLDF. The vasodilator response induced by salbutamol (3.2 x 10(-7), 10(-6), and 3.2 x 10(-6) M) was attenuated by a 15-min suffusion of N omega-nitro-L-arginine (L-NNA, 10(-4) M), and pretreatment with L-arginine (10(-2) M) could restore salbutamol-induced vasodilator responses. Salbutamol-induced vasodilation was also abolished by propranolol (10(-5) M). Similarly, the vasodilator response elicited by isoproterenol (3.2 x 10(-8), 10(-7), and 3.2 x 10(-7) M) and forskolin (3.2 x 10(-7), 10(-6), and 3.2 x 10(-6) M) was inhibited by L-NNA (10(-4) M). In contrast, the vasodilator response induced by adenosine (10(-6), 10(-5), and 10(-4) M) was not affected by L-NNA (10(-4) M). These data indicate that in rat diaphragmatic microcirculation salbutamol-induced vasodilation may be partly mediated by beta-adrenoceptors on the endothelium. Moreover, these data suggest that an elevation of cyclic AMP in the endothelium may cause release of NO.

scholarly journals Relationship Between Laser Doppler Signals and Anatomy During Deep Brain Stimulation Electrode Implantation Toward the Ventral Intermediate Nucleus and Subthalamic Nucleus

2012 ◽  
Vol 72 (2) ◽  
pp. ons127-ons140 ◽  
Author(s):  
Karin Wårdell ◽  
Peter Zsigmond ◽  
Johan Richter ◽  
Simone Hemm
Keyword(s):  
Blood Flow ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Laser Doppler ◽  
Optical Measurements ◽  
Microvascular Blood Flow ◽  
Intermediate Nucleus ◽  
Ventral Intermediate Nucleus ◽  
Deep Brain

Abstract BACKGROUND: Deep brain stimulation (DBS) requires precise and safe navigation to the chosen target. Optical measurements allow monitoring of gray-white tissue boundaries (total light intensity [TLI]) and microvascular blood flow during stereotactic procedures. OBJECTIVE: To establish the link between TLI/blood flow and anatomy along trajectories toward the ventral intermediate nucleus (Vim) and subthalamic nucleus (STN). METHODS: Stereotactic laser Doppler measurements were obtained with millimeter precision from the cortex toward the Vim (n = 13) and STN (n = 9). Optical trajectories of TLI and blood flow were created and compared with anatomy by superimposing the Schaltenbrandt-Wahren atlas on the patients' pre- and postoperative images. Measurements were divided into anatomic subgroups and compared statistically. RESULTS: Typical TLI trajectories with well-defined anatomic regions could be identified for the Vim and STN. TLI was significantly lower (P < .001) and microvascular blood flow significantly higher (P = .01) in the Vim targets. Of 1285 sites, 38 showed blood flow peaks, 27 of them along the Vim trajectories. High blood flow was more common close to the sulci and in the vicinity of the caudate/putamen. Along 1 Vim trajectory, a slight bleeding was suspected during insertion of the probe and confirmed with postoperative computed tomography. CONCLUSION: Laser Doppler is useful for intraoperative guidance during DBS implantation because simultaneous measurement of tissue grayness and microvascular blood flow can be done along the trajectory with millimeter precision. Typical but different TLI trajectories were found for the Vim and STN.

Microvascular blood flow, volume, and velocity measured by laser Doppler techniques in IDDM

Diabetes ◽  
1989 ◽  
Vol 38 (7) ◽  
pp. 819-824 ◽  
Author(s):  
M. Rendell ◽  
T. Bergman ◽  
G. O'Donnell ◽  
E. Drobny ◽  
J. Borgos ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Doppler ◽  
Microvascular Blood Flow ◽  
Flow Volume ◽  
Blood Flow Volume ◽  
Doppler Techniques

scholarly journals Functionality of skin microhemocirculation in patients with obliterating atherosclerosis of lower extremity arteries as per laser Doppler flowmetry

2017 ◽  
Vol 16 (4) ◽  
pp. 35-41 ◽  
Author(s):  
A. P. Vasiliev ◽  
N. N. Streltsova ◽  
L. A. Salamova
Keyword(s):  
Blood Flow ◽  
Lower Extremity ◽  
Laser Doppler Flowmetry ◽  
Venous Blood ◽  
Blood Rheology ◽  
Laser Doppler ◽  
Peripheral Blood Flow ◽  
Doppler Flowmetry ◽  
High Prevalence ◽  
Comprehensive Study

Introduction. High prevalence and a poor prognosis of obliterating atherosclerosis of lower extremity arteries make the comprehensive study of the disease as a pressing issue. Aim of the study. To reveal features of functional state of lower extremities skin microcirculation (MC) in patients with intermittent claudication (IC). Material and methods. Microcirculation in 75 patients with IC and 15 healthy subjects was assessed by laser Doppler flowmetry. Results. In IC patients compared to healthy people significant decrease in nutritive blood flow by 25.9 % was detected as well as activation of arterio-venous blood shunting (+45.6 %) with venous congestion that causes worsening in blood rheology abnormalities. Conclusion. The detected shifts in MC lead to the progression of functional insufficiency in peripheral blood flow.

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