Can Right Ventricular Lead Position Influence Paced QRS Duration in Patients with Abnormal and Normal Left Ventricular Function?

Valuable Insight ◽

Lead Position ◽

Lead Placement ◽

Ventricular Lead ◽

Qrs Duration

Right ventricular apical pacing (RVAP) in pacemaker or implantable cardioverter‐defibrillator (ICD) therapy has been associated with the development and exacerbation of heart failure (HF). Studies have suggested that RVAP resulting in dyssynchronous left ventricular (LV) activation and prolonged QRS duration leads to progressive mechanical dysfunction, decreased systolic function and increased mortality. These data suggest that the effect may be most pronounced in patients with pre‐existing LV systolic dysfunction. Pacing at the RV septum however has demonstrated narrower paced QRS durations and is being considered as an alternative pacing site to the RVA. In this study, the effect of RV lead placement on the QRS duration in patients with LV systolic dysfunction who demonstrate a left ventricular ejection fraction (LVEF) < 35% and normal LVEF was compared. Patients of a minimum age of 18 years with LVEF ≥ 50% (normal cohort) and LVEF ≤ 30% (HF cohort) were recruited. Four 3 minute high resolution recordings were obtained from an orthogonal lead position for subsequent offline signal averaging. Recordings of native rhythm and pacing at three RV sites: right ventricular outflow tract (RVOT), mid‐septum and RV apex (RVA) were obtained. A 12‐lead electrocardiogram (ECG) recording at each pacing site was stored for later confirmation of pacing location and comparison with paced averaged QRS duration. The QRS duration at different RV sites in the two populations was then compared. As studies to date are limited, this study provided valuable insight on RV lead placement on QRS duration in device therapy for HF treatment.

Left bundle branch pacing: efficacy and safety compared to right ventricular outflow tract pacing

EP Europace ◽

10.1093/europace/euab116.388 ◽

2021 ◽

Vol 23 (Supplement_3) ◽

Author(s):

A Riano Ondiviela ◽

M Cabrera Ramos ◽

JR Ruiz Arroyo ◽

J Ramos Maqueda

Keyword(s):

Right Ventricular ◽

Right Ventricular Outflow Tract ◽

Ventricular Outflow Tract ◽

Left Ventricular ◽

Outflow Tract ◽

Pacing Threshold ◽

Ventricular Lead ◽

Qrs Duration

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Patients with preserved left ventricular ejection fraction (LVEF) and atrioventricular block (AVB) who are anticipated for high-burden of right ventricular (RV) pacing possess a risk to develop pacing-induced cardiomyopathy and adverse clinical outcomes. Left bundle branch pacing (LBBP) has recently emerged as a mode of conduction system pacing in the quest for physiological pacing. Purpose The aim of our study was to assess LBBP feasibility and safety compared to right ventricular outflow tract pacing (RVOTP). Methods Single centre randomized clinical trial to investigate acute success, feasibility and safety of LBBP versus RVOTP. May to October 2020. Patients with pacemaker indication and preserved LVEF were randomized 1:1 and followed up 3 months. Success was defined in LBBP group as a paced ECG < 120ms or with a 20% length reduction from the basal ECG. Results 120 patients were randomized, 60 in each group, 61% males. The mean age was 77,9 ± 9 years and third-degree AVB was the main pacing indication. The procedure was successful in 95% of the cases in both groups (p = 1). The paced QRS interval was narrower in the LBBP group compared to the RVOT group (99 ± 2 ms vs 113,6 ± 11,7 ms, p < 0,001). Lower fluoroscopy times were achieved in LBBP group (3.1 ± 2.1 min vs 4.3 ± 3.4, p = 0,035) and also longer procedure times in LBBP group (68,9 ± 36,9 min vs 44,3 ± 18,7 min, p < 0,001). No complications were achieved and no difference in ventricular lead dislocation was found between both groups (1.6% vs 1.6%)(p = 1). Conclusions LBBP is feasible, safe and provides a narrower paced QRS compared to RVOTP. LBBP required lower fluoroscopy times but longer procedure times compared to RVOTP. LBBP (n = 60) RVOTP (n = 60) p Age (mean ± SD) 76,7 ± 9 79,7 ± 8 0,067 Male gender 62 (37) 60 (36) 1 Successful procedure 95 (57) 95 (57) 1 Basal left bundle branch block 15 (9) 13 (8) Basal QRS duration (mean ± SD) 112,6 ± 29,6 109,9 ± 25,8 0,59 Pacing QRS duration (min)(mean ± SD) 99 ± 2 139,6 ± 11,7 < 0,001 Procedure time (min) (mean ± SD) 68,9 ± 36,9 44,3 ± 18,7 < 0,001 Fuoroscopy time (min)(mean ± SD) 3.1 ± 2.1 4.3 ± 3.4 0,035 R wave (mV)(mean ± SD) 9,9 ± 5,7 9,9 ± 5 0,98 Right ventricle pacing threshold (V)(mean ± SD) 0,67 ± 0,3 0,58 ± 0,24 0,08 Ventricular lead dislocation 1.6 (1) 1.6 (1) 1

Analysis of cardiac involvement in patients recovered from Covid-19 without troponin elevation, evaluated by cardiovascular magnetic resonance.

10.21203/rs.3.rs-901933/v1 ◽

2021 ◽

Author(s):

Adrian Carlessi ◽

Leonel Perello ◽

Cristian Pantaley ◽

Armando Borsini ◽

Lucia Rossi ◽

...

Keyword(s):

Ejection Fraction ◽

Right Ventricular ◽

Cardiac Involvement ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Ventricular Ejection ◽

Ventricular Systolic Dysfunction ◽

Troponin Elevation

Abstract Background The disease caused by coronavirus (COVID-19) affects the cardiovascular system, whether by direct viral aggression or indirectly through systemic inflammation and multiple organ compromise. A widely used method to determine cardiac injury is troponin measurement. The aim of this study is to evaluate the prevalence of cardiac involvement (CINV) in a population recovered from COVID-19, referred to cardiac MRI (CMR), who did not present troponin elevation. Methods There were 156 patients that recovered from COVID-19 and who did not present troponin elevation referred to CMR. CINV was considered to be the presence of: late gadolinium enhancement (LGE), edema, myocarditis, pericarditis, left ventricular systolic dysfunction (LVSD) and/or depressed right ventricular systolic dysfunction (RVSD). Results Prevalence of CINV was 28.8%, being more frequent in men (p = 0.002), in patients who required hospitalization (p = 0.04) and in those who experienced non-mild cases of infection (p = 0.007). RVSD (17.9%) and LVSD (13.4%) were the most frequent findings. The rate of myocarditis was 0.6%. LGE manifested in 7.1% of patients and its presence was related to less left ventricular ejection fraction (LVEF) (p = 0.0001) and right ventricular ejection fraction (RVEF) (p = 0.04). Conclusion In patients who recovered from COVID-19, 28.8% of CINV was found. It was more frequent in men, in patients who required admission and in patients with cases of non-mild infection. The patients that presented LGE had less LVEF and RVSF.

Increased QRS duration and dispersion are associated with mechanical dyssynchrony in patients with permanent right ventricular apical pacing

Discoveries ◽

10.15190/d.2021.7 ◽

2021 ◽

Vol 9 (2) ◽

pp. e128

Author(s):

Elibet Chávez-González ◽

◽

Arian Nodarse-Concepción ◽

Ionuț Donoiu ◽

Fernando Rodríguez-González ◽

...

Keyword(s):

Left Ventricular Ejection Fraction ◽

Ejection Fraction ◽

Right Ventricular ◽

Mechanical Dyssynchrony ◽

Left Ventricular ◽

Ventricular Ejection ◽

Qrs Duration ◽

Right Ventricular Apical Pacing

Background: Permanent right ventricular apical pacing may have negative effects on ventricular function and contribute to development of heart failure. We aimed to assess intra- and interventricular mechanical dyssynchrony in patients with permanent right ventricular apical pacing, and to establish electrocardiographic markers of dyssynchrony. Methods: 84 patients (46:38 male:female) who required permanent pacing were studied. Pacing was done from right ventricular apex in all patients. We measured QRS duration and dispersion on standard 12-lead ECG. Intra- and interventricular mechanical dyssynchrony and left ventricular ejection fraction were assessed by transthoracic echocardiography. Patients were followed-up for 24 months. Results: Six months after implantation, QRS duration increased from 128.02 ms to 132.40 ms, p≤0.05. At 24 months, QRS dispersion increased from 43.26 ms to 46.13 ms, p≤0.05. Intra- and interventricular dyssynchrony increased and left ventricular ejection fraction decreased during follow-up. A QRS dispersion of 47 ms predicted left ventricular dysfunction and long-term electromechanical dyssynchrony with a sensitivity of 80% and a specificity of 76%. Conclusion: In patients with permanent right ventricular apical pacing there is an increased duration and dispersion of QRS related to dyssynchrony and decreased left ventricular ejection fraction. This study shows that QRS dispersion could be a better predictive variable than QRS duration for identifying left ventricular ejection fraction worsening in patients with permanent right ventricular apical pacing. The electrocardiogram is a simple tool for predicting systolic function worsening in these patients and can be used at the bedside for early diagnosis in the absence of clinical symptoms, allowing adjustments of medical treatment to prevent progression of heart failure and improve the patient's quality of life.

Using deep learning algorithms to simultaneously identify right and left ventricular dysfunction from the electrocardiogram.

10.1101/2021.03.31.21254696 ◽

2021 ◽

Author(s):

Akhil Vaid ◽

Kipp W Johnson ◽

Marcus A Badgeley ◽

Sulaiman Somani ◽

Mesude Bicak ◽

...

Keyword(s):

Heart Failure ◽

Deep Learning ◽

Right Ventricular ◽

Systolic Dysfunction ◽

External Validation ◽

Left Ventricular ◽

Lv Function ◽

Left And Right

Background Rapid evaluation of left and right ventricular function using deep learning (DL) on electrocardiograms (ECG) can assist diagnostic workflow. However, DL tools to estimate right ventricular (RV) function do not exist, while ones to estimate left ventricular (LV) function are restricted to quantification of very low LV function only. Objectives This study sought to develop deep learning models capable of comprehensively quantifying left and right ventricular dysfunction from ECG data in a large, diverse population. Methods A multi-center study was conducted with data from five New York City hospitals; four for internal testing and one serving as external validation. We created novel DL models to classify Left Ventricular Ejection Fraction (LVEF) into categories derived from the latest universal definition of heart failure, estimate LVEF through regression, and predict a composite outcome of either RV systolic dysfunction or RV dilation. Results We obtained echocardiogram LVEF estimates for 147,636 patients paired to 715,890 ECGs. We used Natural Language Processing (NLP) to extract RV size and systolic function information from 404,502 echocardiogram reports paired to 761,510 ECGs for 148,227 patients. For LVEF classification in internal testing, Area Under Curve (AUC) at detection of LVEF<=40%, 40%<LVEF<=50%, and LVEF>50% was 0.94 (95% CI:0.94-0.94), 0.82 (0.81-0.83), and 0.89 (0.89-0.89) respectively. For external validation, these results were 0.94 (0.94-0.95), 0.73 (0.72-0.74) and 0.87 (0.87-0.88). For regression, the mean absolute error was 5.84% (5.82-5.85) for internal testing, and 6.14% (6.13-6.16) in external validation. For prediction of the composite RV outcome, AUC was 0.84 (0.84-0.84) in both internal testing and external validation. Conclusions DL on ECG data can be utilized to create inexpensive screening, diagnostic, and predictive tools for both LV/RV dysfunction. Such tools may bridge the applicability of ECGs and echocardiography, and enable prioritization of patients for further interventions for either sided failure progressing to biventricular disease. Keywords Artificial Intelligence, Deep Learning, Machine Learning, HFrEF, Right Ventricular Dilation, Right Ventricular Systolic Dysfunction, echocardiography, electrocardiogram, ECG, EKG, LVEF, Left Ventricular Ejection Fraction, Left Heart Failure, Right Heart Failure

Right ventricular function as a predictor of appropriate therapy of implantable cardioverter defibrillator

EP Europace ◽

10.1093/europace/euab116.427 ◽

2021 ◽

Vol 23 (Supplement_3) ◽

Author(s):

T Chiba ◽

T Kajiyama ◽

M Sugawara ◽

M Kitagawa ◽

H Takahira ◽

...

Keyword(s):

Right Ventricular ◽

Systolic Dysfunction ◽

Univariate Analysis ◽

Left Ventricular ◽

Basal Diameter ◽

Cox Regression Analysis ◽

Icd Therapy ◽

Appropriate Therapy

Abstract Funding Acknowledgements Type of funding sources: None. Aim The purpose of this study was to evaluate the association of RV function and appropriate therapy of ICD.Methods: This study was a single-center retrospective cohort study. Consecutive patients who underwent ICD implantation for any diseases were enrolled except for non-dilated phase hypertrophic cardiomyopathy and channelopathy. Transthoracic echocardiographic parameters including left ventricular ejection fraction (LVEF), RV basal diameter, RV end-diastolic area, and right ventricular fractional area change (RVFAC) were evaluated. RV systolic dysfunction was defined as RVFAC <35%. Cox regression analysis was used to analyze the effects of those parameters on appropriate ICD therapy after the implantation. Results In total, 151 patients (60.9 ± 13.6 years, 117 males) consisting of 67 old myocardial infarction, 34 dilated cardiomyopathy, 19 cardiac sarcoidosis, and 31 others were enrolled. Eighty patients received an ICD as a secondary prophylaxis. Mean LVEF and RVFAC were 37.8 ± 13.9% and 33.2 ± 10.8%, respectively. RV systolic dysfunction was present in 86 (57.0%) patients, which was significantly associated with ICD therapy (odds ratio 2.313; 95% confidence interval 1.067-5.014; P = 0.034) according to a univariate analysis. There was no correlation between RVFAC and LVEF (correlation coefficient =0.064). Regarding the subjects LVEF > 35%, RV systolic dysfunction was an independent predictor of ICD therapy in a multivariate analysis. Conclusion RV systolic dysfunction was independently associated with increased ICD therapy despite of relatively preserved LVEF.

Right ventricular systolic dysfunction in patients with coronary artery disease: gender-related differences

Clinical Medicine (Russian Journal) ◽

10.18821/0023-2149-2017-95-10-894-900 ◽

2017 ◽

Vol 95 (10) ◽

pp. 894-900

Author(s):

Alexey N. Sumin ◽

E. V. Korok ◽

O. G. Arhipov

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Right Ventricular ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Insurance Fund ◽

Ventricular Systolic Dysfunction ◽

Artery Disease

Right ventricular (RV) dysfunction is one of the most significant independent predictors of prognosis in patients with coronary artery disease (CAD) presenting with and without myocardial infarction (MI). However, gender-related differences in RV function of CAD patients are still poorly understood. Aim. To elucidate gender-related differences in echocardiographic parameters of the right chambers of the heart in CAD patients. Material and Methods. 719 patients with coronary artery disease undergoing medical examination in the Federal Budgetary Institution Rehabilitation Center «Topaz» of the RF Social Insurance Fund were included in the study. All patients were assigned to two groups according to the gender: Group 1 - men (n = 432, 61 [55; 67] years), Group 2 - women (n = 287, 62 [56; 67] years). Results. The analysis of the structure and systolic function of the RV showed that RV and right atrium (RA) end-diastolic dimension, diastolic RV wall thickness, and RA area were significantly higher in men than in women (p <0.001). Thus, the prevalence of RV systolic dysfunction (SD) was similar in both groups of patients: 17.6% in men and 15% in women (p = 0.356). The independent predictors of LV SD in both groups were as follows: prior coronary artery bypass grafting (CABG), decreased early mitral flow propagation velocity (p > 0.05). However, reduced left ventricular ejection fraction (LVEF; p <0.001) was found only in men. Conclusion. The prevalence of right ventricular systolic dysfunction in patients with coronary artery disease was similar in both men and women. Men demonstrated lower values of systolic and diastolic LV function. The factors associated with RV systolic dysfunction in both groups were as follows: prior CABG and diastolic LV dysfunction. Reduced LVEF was found only in men. The results of this study can be used to assess gender-related differences in RV dysfunction in CAD patients.

The effect of right ventricular pacemaker lead position on functional status in patients with preserved left ventricular ejection fraction

Medicinski pregled ◽

10.2298/mpns1608212m ◽

2016 ◽

Vol 69 (7-8) ◽

pp. 212-216

Author(s):

Vladimir Mitov ◽

Zoran Perisic ◽

Aleksandar Jolic ◽

Tomislav Kostic ◽

Aleksandar Aleksic ◽

...

Keyword(s):

Right Ventricle ◽

Right Ventricular ◽

Right Ventricular Outflow Tract ◽

Ventricular Outflow Tract ◽

Left Ventricular ◽

Outflow Tract ◽

Lead Position ◽

The Right

Introduction. The study was aimed at assessing the difference between the right ventricle apex versus the right ventricular outflow tract lead position in functional capacity in the patients with the preserved left ventricular ejection fraction after 12 months of pacemaker stimulation. Material and Methods. This was a prospective, randomized, follow-up study, which lasted for 12 months. The study sample included 132 consecutive patients who were implanted with permanent anti-bradicardiac pacemaker. Regarding the right ventricular lead position the patients were divided into two groups: the right ventricle apex group consisting of 61 patients with right ventricular apex lead position. The right ventricular outflow tract group included 71 patients with right ventricular outflow tract lead position. Functional capacity was assessed by Minnesota Living With Heart Failure score, New York Heart Association class and Six Minute Walk Test. Left ventricular ejection fraction was assessed by echocardiography. Results. Minnesota Living With Heart Failure score and New York Heart Association class had a statistically significant improvement in both study groups. The patients from right ventricle apex group walked 20.95% (p=0.03) more in comparison to starting values. The patients from right ventricular outflow tract group walked only 13.63% (p=0.09) longer distance than the starting one. Conclusion. Analysis of tests of functional status New York Heart Association class and Minnesota Living With Heart Failure questionnaire showed an even improvement in the right ventricle apex and right ventricular outflow tract groups. Analysis of 6 minute walk test showed that only the patients with the preserved left ventricular ejection fraction from the right ventricle apex group had a significant improvement after 12 months of pacemaker stimulation.

604 Echocardiographic assessment of right ventricular function and pulmonary pressures in hospitalized patients with COVID-19

European Heart Journal Supplements ◽

10.1093/eurheartj/suab135.020 ◽

2021 ◽

Vol 23 (Supplement_G) ◽

Author(s):

Maria Vincenza Polito ◽

Marco Di Maio ◽

Angelo Silverio ◽

Michele Bellino ◽

Serena Migliarino ◽

...

Keyword(s):

Regression Analysis ◽

Right Ventricular ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Secondary Outcome ◽

Systolic Pulmonary Artery Pressure ◽

Icu Patients ◽

Risk Of Death

Abstract Aims Pulmonary involvement in Coronavirus 19 disease (COVID-19) may affect right ventricular (RV) function and pulmonary pressures resulting in further deterioration of patient clinical status. However, the prognostic value of echocardiographic parameters including tricuspid annular plane systolic excursion (TAPSE), systolic pulmonary artery pressure (PASP), and TAPSE/PASP ratio has been poorly investigated in this clinical setting. Methods and results This is a multicentre Italian study including patients admitted for severe COVID-19 in seven Italian Hospitals. Transthoracic echocardiography (TTE) was performed within 48 h from admission in all cases. In-hospital mortality and pulmonary embolism (PE) were identified as the primary and secondary outcome measures, respectively. Of 1401 patients with severe COVID-19, 227 (16.1%) subjects underwent TTE within 48 h from admission and were included in this study. The mean age was 68 ± 13 years and 62.6% of patients were male. Intensive care unit (ICU) admission was reported in 73 patients (32.2%); ICU patients showed lower left ventricular ejection fraction (LVEF), lower TAPSE, and higher LV end systolic volume and PASP values than non-ICU patients. Also, ICU patients showed higher incidence of acute respiratory distress syndrome (82.2% vs. 30.5%; P < 0.001), acute cardiac injury (46.6% vs. 22.7%; P < 0.001), acute heart failure (34.2% vs. 9.1%; P < 0.001), and death (63.9% vs. 14.3%; P < 0.001) compared with non-ICU patients. By stratifying the study population into tertiles according to TAPSE, PASP, and TAPSE/PASP values, patients in the lower TAPSE and TAPSE/PASP ratio tertiles, and those in the higher PASP tertile, showed a significantly higher incidence of death during the hospitalization. At univariable logistic regression analysis, TAPSE, PASP, and TAPSE/PASP were significantly associated with a higher risk of death and PE, both in patients admitted or not to ICU. After propensity score weighting adjustment for multiple baseline potential confounders and further multivariable adjustment for LVEF value, the regression analysis showed that TAPSE, PASP and TAPSE/PASP were independently associated with risk of death (TAPSE: OR: 0.85, CI: 0.74–0.97, P = 0.017; PASP: OR: 1.08, CI: 1.03–1.13, P = 0.002; TAPSE/PASP: OR: 0.02, CI: 0.02 × 10−1—0.20, P < 0.001) and with the risk of PE (TAPSE: OR: 0.70, CI: 0.60–0.82, P < 0.001; PASP: OR: 1.10, CI: 1.05–1.14, P < 0.001; TAPSE/PASP: OR: 0.02 × 10−1, CI: 0.01 × 10−2—0.04, P < 0.001) during the hospitalization. The risk death according to TAPSE, PASP, and TAPSE/PASP ratio tertiles was estimated considering discharge alive as competing risk (Figure). The lowest TAPSE and TAPSE/PASP tertiles, and the highest PASP tertile, were significantly associated with poorer survival during the hosptialization (P < 0.001). Conclusions Echocardiographic evidence of RV systolic dysfunction, increased PASP and a poor RV-arterial coupling assessed by TAPSE/PAPS ratio may help to identify COVID-19 patients at higher risk of mortality and PE during the hospitalization.

Influence of baseline QRS on the left ventricular ejection fraction recovery after frequent premature ventricular complex ablation

EP Europace ◽

10.1093/europace/euz330 ◽

2020 ◽

Vol 22 (2) ◽

pp. 274-280 ◽

Cited By ~ 1

Author(s):

Diego Penela ◽

Beatriz Jáuregui ◽

Juan Fernández-Armenta ◽

Luis Aguinaga ◽

Luis Tercedor ◽

...

Keyword(s):

Left Ventricular Ejection Fraction ◽

Ejection Fraction ◽

Left Ventricular Systolic Dysfunction ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Ventricular Ejection ◽

Premature Ventricular Complex ◽

Qrs Duration

Abstract Aims Frequent premature ventricular complexes (PVCs) can induce or worsen left ventricular systolic dysfunction. We aimed to investigate the influence of the baseline QRS in the response after PVC ablation in patients with depressed left ventricular ejection fraction (LVEF). Methods and results Two hundred and fifteen [59 ± 13 years old, 152 (71%) men] consecutive patients with left ventricular (LV) systolic dysfunction and frequent PVCs referred for ablation were included and followed-up for 12 months. Echocardiographic response was defined as an improvement of at least five absolute points in LVEF. Clinical, electrocardiogram, and electrophysiological characteristics were analysed. Mean baseline QRS duration was 110 ms [97–140]. Premature ventricular complex burden significantly decreased after ablation from 23% [16–33] at baseline to 1% [0–8] at 12 months, P < 0.001. Mean PVC burden reduction was 18 [8–30] points. There was a significant improvement of LVEF from 35% [29–40] at baseline to 44% [35–55] at 12 months, P < 0.001. One hundred and thirty (61%) patients were considered as echocardiographic responders. Baseline QRS duration (ms) [odds ratio (OR) 0.98 (0.97–0.99), P = 0.01] was an independent predictor of echocardiographic response. Mean LVEF improvement was 16 [10–21] points when the baseline QRS duration was <90 ms; 12 [4–20] when it was 90–110 ms; 5 [0–15] when it was 110 ± 130 ms; and 0 [0–6] points when it was >130 ms. Conclusions In patients with LV systolic dysfunction, intrinsic QRS duration is inversely related to the probability and the degree of echocardiographic response after frequent PVC ablation. Patients with a QRS duration >130 ms at baseline have the poorer response after ablation.