An 88-year old man with spontaneous splenic rupture after granulocyte colony stimulating factor administration

2020 ◽  
pp. 285-287
Author(s):  
Marta Martinez ◽  
Cristina Maza
Keyword(s):  
Splenic Rupture ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Spontaneous Splenic Rupture ◽  
Stimulating Factor

Atraumatic idiopathic splenic rupture induced by granulocyte-colony stimulating factor (G-CSF) for the treatment of pancytopenia, managed successfully by laparoscopic splenectomy

2020 ◽  
Vol 13 (4) ◽  
pp. e232411 ◽  
Author(s):  
Ugochukwu Chinyere Chinaka ◽  
Joshua Fultang ◽  
Jelizaveta Pereca ◽  
Abdulmajid Ali
Keyword(s):  
Laparoscopic Splenectomy ◽  
Splenic Rupture ◽  
University Hospital ◽  
Haemodynamic Instability ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Threatening Condition ◽  
Life Threatening ◽  
Stimulating Factor ◽  
Factor G

Splenic rupture is a potentially life-threatening condition and an uncommon short-term complication of granulocyte-colony stimulating factor (G-CSF) administration. It may present as acute abdominal pain or suddenly precipitously worsening anaemia with haemodynamic instability that requires urgent operative intervention for survival. We present a case of an atraumatic idiopathic splenic rupture in University Hospital, Ayr in a patient who received G-CSF treatment for chemotherapy-induced (methotrexate) pancytopenia and was successfully managed by laparoscopic splenectomy.

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