Optimal Cutoff Values of Allergen-specific Immunoglobulin E to House Dust Mites and Animal Dander Based on Skin-prick Test Results: Analysis in 16,209 Patients with Allergic Rhinitis

2018 ◽  
Vol 32 (1) ◽  
pp. 23-26 ◽  
Author(s):  
Sang Duk Hong ◽  
Gwanghui Ryu ◽  
Min Young Seo ◽  
Jong In Jeong ◽  
Hyo Yeol Kim ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Immunoglobulin E ◽  
House Dust Mites ◽  
Test Results ◽  
Dust Mites ◽  
Cutoff Value ◽  
Prick Test ◽  
Specific Immunoglobulin E ◽  
Animal Dander

Background The most common tests for allergen sensitization in patients with allergic rhinitis are the skin-prick test (SPT) and an in vitro test to detect serum specific immunoglobulin E (sIgE). However, in vitro allergen test results were interpreted dichotomically as positive or negative at a threshold of 0.35 kU/L of sIgE, regardless of the patient characteristics or antigen types. Objective The purpose of this study was to determine the cutoff value for sIgE in house-dust mites and animal dander, and to analyze differences in cutoff value according to age and gender. Methods A total of 16,209 patients with more than one allergic rhinitis symptom who underwent both SPT and serum sIgE testing were retrospectively evaluated between March 2008 and May 2012. There were 9374 male (57.8%) and 6835 female (42.2%) patients. The mean age was 31.8 years (range, 2–89 years). The criterion standard for allergen sensitization was defined as a wheal of >3 mm or an allergen-to-histamine ratio of ≥1 in SPT results. The Youden index was used to calculate the cutoff value of sIgE. Results Cutoff values of sIgE for Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, and dog were 0.69, 1.16, 0.13, and 0.45 kU/L, respectively. The cutoff value of sIgE changed according to age for D. pteronyssinus and D. farinae but not for cat and dog allergens. When categorizing according to age group, the cutoffvalues ofsIgE for D. pteronyssinus and D. farinae had a tendency to decrease with age. There was no significant difference in cutoffvalue according to gender. Conclusion The cutoffvalue for sIgE differed for each antigen and changed with age. Physicians should select the proper cutoffvalue for sIgE for appropriate criteria according to antigen and patient age rather than using a uniform cutoffvalue.

scholarly journals Could FeNO Predict Asthma in Patients with House Dust Mites Allergic Rhinitis?

Medicina ◽  
2020 ◽  
Vol 56 (5) ◽  
pp. 235
Author(s):  
Ioana Adriana Muntean ◽  
Ioana Corina Bocsan ◽  
Stefan Vesa ◽  
Nicolae Miron ◽  
Irena Nedelea ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
Immunoglobulin E ◽  
Biological Evaluation ◽  
House Dust Mites ◽  
Dust Mites ◽  
Persistent Allergic Rhinitis ◽  
Tnf Α ◽  
One Year ◽  
High Level

Background and Objectives: The evolution of allergic rhinitis to asthma is a part of “atopic march”. The aim of this study was to analyze possible predictive markers for asthma occurrence in patients with allergic rhinitis to house dust mites (HDM). Materials and Methods: Fifty-eight patients with persistent allergic rhinitis (PAR) were included. The clinical, biological evaluation and fractionated exhaled nitric oxide (FeNO) measurement were performed at enrolment. The patients were clinically evaluated after one year to determine asthma occurrence. Results: The severity of rhinitis symptoms, levels of total immunoglobulin E (IgE), ICAM-1, VCAM-1, E-selectin and IL-6, but not IL-8 and TNF-α were higher in patients with allergic rhinitis who developed asthma compared to non-asthmatics, but the differences were not significant to considered them as predictive factors for asthma occurrence. The risk of asthma was independently influenced by patients aged over 30 years ((OR-3.74; CI95% 0.86–16.31; p = 0.07), a duration of allergic rhinitis over 12 months ((OR-4.20; CI95% 0.88–20; p = 0.07) and a basal FeNO over 28 parts per billion (pbb) ((OR-18.68; CI95% 3.79–92.05; p < 0.001). Conclusion: Clinical and biological parameters may predict asthma occurrence in patients with persistent allergic rhinitis to HDM. Adult patients with a longer duration of rhinitis symptoms and a high level of FeNO have a greater risk to develop asthma.

scholarly journals High Dust Mite specific Immunoglobulin E (sIgE): a Promising Indicator of Allergic Rhinitis to Asthma

2020 ◽  
Author(s):  
Rui Tang ◽  
Xiaohong Lyu ◽  
Yuelun Zhang ◽  
Shi Chen ◽  
Hong Li
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Immunoglobulin E ◽  
House Dust Mites ◽  
Kaplan Meier ◽  
Sige Level ◽  
Specific Immunoglobulin E ◽  
Dust Mite ◽  
Specific Immunoglobulin

Abstract Background: House dust mites are the most prevalent allergens in patients with asthma and/or rhinitis in China. Cross-sectional data in 2009 have shown that allergic rhinitis often preceded or occurred at the same time as asthma in patients which was used to investigate the association of serum specific immunoglobulin E (sIgE) levels to house dust mite with the onset of asthma in patients with allergic rhinitis. Methods: 321 patients with allergic rhinitis were face-to-face interviewed and underwent sIgE tests to house dust mite. The temporal sequence of allergic rhinitis and asthma was documented. Univariate analysis, multinomial logistic regression, and Kaplan-Meier survival analysis were performed. Results: Of the 321 participants, 213 (66.4%) had asthma, which occurred after or simultaneously with rhinitis, and 108 (33.6%) suffered from allergic rhinitis only. After controlling basic parameters, factors correlated to sIgE, and essential factors considered by clinical allergists, the risk of developing asthma always increased with the levels of sIgE to house dust mite in all four models (p < 0.01). In Kaplan–Meier analysis, in the first ten years with allergy rhinitis, a high sIgE level represented a high probability of the coexistence of allergic rhinitis and asthma (p < 0.01). For house dust mite sIgE level 5-6, 5 years Rhinitis-Asthma Conversion Rate (RACR) had reached almost 70%. Conclusion: High-level house dust mite sIgE can exist as an indicator of rhinitis to asthma. It provides a theoretical basis for early intervention in patients with high sIgE levels in order to prevent asthma. This assessment and intervention should be performed at the early stage of rhinitis.

Importance of house dust and storage mites in canine atopic dermatitis in the geographic region of Galicia, Spain

2008 ◽  
Vol 56 (2) ◽  
pp. 163-171 ◽  
Author(s):  
Ana Goicoa ◽  
Luciano Espino ◽  
Isabel Rodríguez ◽  
Anna Puigdemont ◽  
Pilar Brazis ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
House Dust ◽  
Immunoglobulin E ◽  
Geographic Area ◽  
Geographic Region ◽  
House Dust Mites ◽  
Dust Mites ◽  
Storage Mites ◽  
Canine Atopic Dermatitis

Sensitisation to mites is frequent in atopic dogs. The main mite genus involved in canine atopic dermatitis is Dermatophagoides . The importance of storage mite allergens in dogs has been controversial. The aim of this study was to evaluate the sensitisation rates against storage mites ( Lepidoglyphus destructor and Tyrophagus putrescentiae ) and house dust mites ( Dermatophagoides farinae and D. pteronyssinus ) in atopic dogs from Galicia, a highly humid and temperate region of Spain, using a FcɛRIα-based immunoglobulin E (IgE) in vitro test. The study was performed on 95 dogs suffering from atopic dermatitis and presenting detectable specific serum IgE levels: 91.6% of the dogs tested positive for storage mites, whereas sensitisation to house dust mites was detected in 87.4%. These results indicate the importance of storage mites in this specific geographic area.

scholarly journals Skin prick test positivity to house dust mites (HDM) in patients with chronic urticaria

2017 ◽  
Vol 3 (1) ◽  
pp. 7 ◽  
Author(s):  
Mounika K. ◽  
K. N. Shivaswamy
Keyword(s):  
Skin Prick Test ◽  
Chronic Urticaria ◽  
House Dust ◽  
Antigenic Property ◽  
House Dust Mites ◽  
Dust Mites ◽  
Female Ratio ◽  
Prick Test ◽  
Immunological Process ◽  
Animal Dander

<p class="abstract"><strong>Background:</strong> The urticaria lasting for more than 6 weeks is termed chronic urticaria. The etiology of chronic urticaria and angioedema remains uncertain in most of the patients. Aeroallergens can induce or exacerbates chronic urticaria. The common aeroallergens are house dust mites (HDM), pollens, moulds, etc. House dust mites can trigger immunological process through ingestion, inhalation or inoculation. These mite allergens are resistant to high temperatures, and do not lose their antigenic property even on cooking. HDMs can also cause worsening of existing atopic dermatitis. Skin test with HDMs is well known to cause irritation due to their proteolytic enzymes.The study was undertaken with the objective to study the skin prick test positivity to house dust mites in patients with chronic urticaria<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> The study was done on 56 consecutive patients of clinically diagnosed cases of chronic urticaria attending the OPD. The skin prick test was done according to the standard protocol.<strong></strong></p><p class="abstract"><strong>Results:</strong> We had a total of 56 patients with chronic urticaria, of which males were 30 and females were 26 with a male to female ratio of 1:0.8. Of the 56 patients with chronic urticaria skin prick test to HDM was seen in 8 (14.2%) patients. <em>D. pteronysinnus</em> 6 (10.7%) constituted the majority among the HDM positivity followed by <em>D. farinae</em> 2(3.5%). We also found skin prick test positivity to pollens, moulds and animal dander in 5, 4 and 2 patients respectively<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> House dust mites can cause or trigger the urticarial symptoms and one should consider to do skin prick test to HDM in identifying the cause and thereby reliving the symptoms of urticaria on its avoidance<span lang="EN-IN">.</span></p>

scholarly journals Clinical Distinctness of Allergic Rhinitis in Patients with Allergy to Molds

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Krzysztof Kołodziejczyk ◽  
Andrzej Bozek
Keyword(s):  
Allergic Rhinitis ◽  
Allergic Sensitization ◽  
House Dust Mites ◽  
Study Group ◽  
Dust Mites ◽  
High Concentration ◽  
Prick Test ◽  
Fungal Allergens ◽  
Inhalant Allergens ◽  
High Level

Introduction. Molds are a very diverse group of allergens. Exposure and sensitization to fungal allergens can promote the development and worsening of allergic rhinitis (AR).Objective. The natural course of allergic rhinitis was compared between a group of patients with allergy to molds and patients with AR to other allergens as the control groups.Material and Methods. The study group consisted of 229 patients, with a mean age of27.4±6.5 yrs. The study group was compared to groups of AR patients with allergy to house dust mites or pollens or with multivalent allergy. Allergic sensitization was assessed using the skin prick test (SPT) with a panel of 15 allergens to molds and other common inhalant allergens. Specific IgEs against all tested allergens were measured. Nasal fractional exhaled nitric oxide (FeNO) level was assessed with a chemiluminescence analyzer (NIOX MINO) and compared between groups. Cluster analysis was performed for determine models of AR in whole population.Results. Patients with allergy to mold have had AR with a higher blockage of nose than in the patients with other allergies.Alternaria alternata(59% of examined),Cladosporium herbarum(40%), andAspergillus fumigatus(36%) were the predominant allergens in the study group. Patients with allergy to mold were more often present in two clusters: there were patients with more frequent accompanying asthma and high level of FeNO.Conclusion. Patients with allergy to molds have a significantly greater predisposition for bronchial asthma and high concentration of FeNO.

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