scholarly journals Role of Neuroplasticity of Spinal Cord Neurons in Developing Rat Neuropathic Pain : Effects of a Novel N-type Ca Channel Blocker, ONO 2921 on Synaptic Transmission of Spinal Cord

2003 ◽  
Vol 57 (1.2) ◽  
pp. 38-39
Author(s):  
Toru Tsukamoto
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Synaptic Transmission ◽  
Channel Blocker ◽  
Ca Channel ◽  
Spinal Cord Neurons ◽  
Developing Rat

Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain

2007 ◽  
Vol 55 (2) ◽  
pp. 158-166 ◽  
Author(s):  
D SINISCALCO ◽  
C FUCCIO ◽  
C GIORDANO ◽  
F FERRARACCIO ◽  
E PALAZZO ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Spinal Cord ◽  
Neuropathic Pain ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Apoptotic Genes

scholarly journals Role of Neuregulin-1/ErbB Signaling in Stem Cell Therapy for Spinal Cord Injury-Induced Chronic Neuropathic Pain

Stem Cells ◽  
2012 ◽  
Vol 31 (1) ◽  
pp. 83-91 ◽  
Author(s):  
Feng Tao ◽  
Qun Li ◽  
Su Liu ◽  
Haiying Wu ◽  
John Skinner ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Stem Cell ◽  
Cell Therapy ◽  
Chronic Neuropathic Pain ◽  
Neuregulin 1 ◽  
Cord Injury ◽  
Erbb Signaling

scholarly journals Sensory Neurons, Ion Channels, Inflammation and the Onset of Neuropathic Pain

2012 ◽  
Vol 39 (4) ◽  
pp. 416-435 ◽  
Author(s):  
Patrick L. Stemkowski ◽  
Peter A. Smith
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Peripheral Neuropathy ◽  
Pain Management ◽  
Sensory Neurons ◽  
Inflammatory Mediators ◽  
Primary Afferents ◽  
Ectopic Activity ◽  
Management Procedures

Neuropathic pain often fails to respond to conventional pain management procedures. here we review the aetiology of neuropathic pain as would result from peripheral neuropathy or injury. We show that inflammatory mediators released from damaged nerves and tissue are responsible for triggering ectopic activity in primary afferents and that this, in turn, provokes increased spinal cord activity and the development of ‘central sensitization’. Although evidence is mounting to support the role of interleukin-1β, prostaglandins and other cytokines in the onset of neuropathic pain, the clinical efficacy of drugs which antagonize or prevent the actions of these mediators is yet to be determined. basic science findings do, however, support the use of pre-emptive analgesia during procedures which involve nerve manipulation and the use of anti-inflammatory steroids as soon as possible following traumatic nerve injury.

Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury

2010 ◽  
Vol 1198 (1) ◽  
pp. 168-172 ◽  
Author(s):  
Tera Hasbargen ◽  
Mostafa M. Ahmed ◽  
Gurwattan Miranpuri ◽  
Lin Li ◽  
Kristopher T. Kahle ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Chronic Neuropathic Pain ◽  
Cord Injury

scholarly journals Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats

2005 ◽  
Vol 54 (2) ◽  
pp. 102-108 ◽  
Author(s):  
Koichi Hayashi ◽  
Shu Wakino ◽  
Yuri Ozawa ◽  
Koichiro Homma ◽  
Takeshi Kanda ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Spontaneously Hypertensive Rats ◽  
Channel Blocker ◽  
Ca Channel ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Kinase C

The presence of glia stimulates the appearance of glycinergic synaptic transmission in spinal cord neurons

2005 ◽  
Vol 28 (4) ◽  
pp. 770-778 ◽  
Author(s):  
Magdalena E. Cuevas ◽  
Mónica A. Carrasco ◽  
Yuly Fuentes ◽  
Patricio Castro ◽  
Francisco Nualart ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Synaptic Transmission ◽  
Spinal Cord Neurons
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