scholarly journals Simultaneous Determination of Metformin and Glimepiride in Fixed-Dose Combination Tablets Sold in Pramuka Market using Validated UV Spectrophotometric Method

2021 ◽  
Vol 8 (3) ◽  
pp. 303
Author(s):  
Zilhadia Zilhadia ◽  
Supandi Supandi ◽  
Salman Alfarisi
Keyword(s):  
Simultaneous Determination ◽  
Spectrophotometric Method ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Dose Combination

NOVEL UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF SITAGLIPTIN PHOSPHATE AND SIMVASTATIN BY AREA UNDER CURVE METHOD

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (04) ◽  
pp. 46-52
Author(s):  
V. V. Chopde ◽  
◽  
P. M. Patil ◽  
S. D Rathod ◽  
P. D. Chaudhari
Keyword(s):  
Simultaneous Determination ◽  
Wavelength Range ◽  
Spectrophotometric Method ◽  
Area Under Curve ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Economic Method ◽  
Curve Method ◽  
Dose Combination

A simple, versatile, accurate, precise and economic method for simultaneous determination of sitagliptin phosphate and simvastatin in fixed dose combination products was developed. The absorbance values at 267 nm and 239 nm for sitagliptin phosphate and simvastatin. The combination is also estimated by AUC method it involved measurement of area under curve in the wavelength range is 264-270 nm (λ1 -λ2 ) and 236-242 nm (λ3 -λ4 ) sitagliptin phosphate and simvastatin respectively. This method obeyed Beer’s law in the concentration range of 10-60 μg /mL for sitagliptin phosphate and 2-12 μg /mL for simvastatin. The results of analyses have been validated statistically for linearity, accuracy, precision, LOD and LOQ of the proposed method.

Development and Validation of an HPLC Method for Simultaneous Determination of Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol Hydrochloride in Pharmaceutical Formulations

2015 ◽  
Vol 98 (5) ◽  
pp. 1234-1239 ◽  
Author(s):  
Paula R Chellini ◽  
Eduardo B Lages ◽  
Pedro H C Franco ◽  
Fernando H A Nogueira ◽  
Isabela C César ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Combined Treatment ◽  
Pharmaceutical Formulations ◽  
Gradient Elution ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Array Detector ◽  
Equilibration Time ◽  
Dose Combination

Abstract Tuberculosis treatment consists of a fixed dose combination of rifampicin (RIF), isoniazid (INH), pyrazinamide (PYZ), and ethambutol hydrochloride (EMB). The combined treatment using various drugs is necessary for patient curing, without recrudescence, and for prevention of drug-resistant mutants, which may occur during treatment. An HPLC-diode array detector (DAD) method for the simultaneous determination of RIF, INH, PYZ, and EMB in fixed dose combination tablets was developed and validated. Chromatographic experiments were performed on an Agilent 1200 HPLC system, and the separation was carried out on a Purospher STAR RP18e (250 × 4.6 mm id, 5 μm, Merck) analytical column. Gradient elution was carried out with a mobile phase of 20 mM monobasic sodium phosphate buffer with 0.2% triethylamine (pH 7.0) and acetonitrile at a flow rate of 1.5 mL/min. The total run time was 12 min, and the re-equilibration time was 5 min. EMB detection was performed at 210 nm, and RIF, INH, and PYZ were detected at 238 nm, using a DAD. The method proved to be specific, linear (r2 > 0.99), precise (RSD <2%), accurate, and robust and may be applied to the QC analysis of pharmaceutical formulations.

Use of chemometrics to compare NIR and HPLC for the simultaneous determination of drug levels in fixed-dose combination tablets employed in tuberculosis treatment

2018 ◽  
Vol 149 ◽  
pp. 557-563 ◽  
Author(s):  
Kelly Sivocy Sampaio Teixeira ◽  
Said Gonçalves da Cruz Fonseca ◽  
Luís Carlos Brigido de Moura ◽  
Mario Luís Ribeiro de Moura ◽  
Márcia Herminia Pinheiro Borges ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Tuberculosis Treatment ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Drug Levels ◽  
Dose Combination

scholarly journals Simultaneous Determination of a Fixed-Dose Combination of Lercanidipine and Valsartan in Human Plasma by LC–MS-MS: Application to a Pharmacokinetic Study

2016 ◽  
Vol 54 (9) ◽  
pp. 1553-1559 ◽  
Author(s):  
Eboka Majolene B. Sabi-mouka ◽  
Janvier Engelbert Agbokponto ◽  
Run Zhang ◽  
Qian Li ◽  
Li Ding
Keyword(s):  
Simultaneous Determination ◽  
Human Plasma ◽  
Pharmacokinetic Study ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Dose Combination

Development of a robust SFC method for evaluation of compatibility for a novel antituberculotic fixed-dose combination

2019 ◽  
Vol 11 (13) ◽  
pp. 1777-1787 ◽  
Author(s):  
Valentina Petruševska ◽  
Iva Krtalić ◽  
Andrea Rašić ◽  
Ana Mornar
Keyword(s):  
Simultaneous Determination ◽  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Chromatography Method ◽  
Dose Combination

A fast and simple supercritical fluid chromatography method for the simultaneous determination of two antituberculotic drugs, isoniazid and rifabutin, and their impurities from a new proposed fixed-dose combination (FDC) was developed.

Simultaneous determination of artemether and lumefantrine in fixed dose combination tablets by HPLC with UV detection

2008 ◽  
Vol 48 (3) ◽  
pp. 951-954 ◽  
Author(s):  
Isabela da Costa César ◽  
Fernando Henrique Andrade Nogueira ◽  
Gérson Antônio Pianetti
Keyword(s):  
Simultaneous Determination ◽  
Uv Detection ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Dose Combination

scholarly journals A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products

2013 ◽  
Vol 12 (1) ◽  
pp. 145 ◽  
Author(s):  
Sultan Suleman ◽  
Kirsten Vandercruyssen ◽  
Evelien Wynendaele ◽  
Matthias D’Hondt ◽  
Nathalie Bracke ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Hplc Method ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Stability Indicating ◽  
Dose Combination

scholarly journals Innovative stability-indicating LC-Corona CAD method for simultaneous determination of assay in Artesunate and Mefloquine hydrochloride fixed-dose combination product

2021 ◽  
pp. 103657
Author(s):  
Wilson Camargo ◽  
Diogo Dibo ◽  
Monique Silva dos Santos ◽  
Ivone de Jesus do Nascimento Lopes ◽  
Flávia Furtado de Mendonça de Sousa ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Combination Product ◽  
Stability Indicating ◽  
Dose Combination ◽  
Corona Cad

scholarly journals Development and validation of an HPLC method for the simultaneous determination of artesunate and mefloquine hydrochloride in fixed-dose combination tablets

2013 ◽  
Vol 49 (4) ◽  
pp. 837-843 ◽  
Author(s):  
Fernando Henrique Andrade Nogueira ◽  
Naialy Fernandes Araújo Reis ◽  
Paula Rocha Chellini ◽  
Isabela da Costa César ◽  
Gerson Antônio Pianetti
Keyword(s):  
Simultaneous Determination ◽  
Potassium Phosphate ◽  
Hplc Method ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Array Detector ◽  
Control Analysis ◽  
Dose Combination ◽  
Development And Validation

The present study developed and validated an HPLC method for the simultaneous determination of artesunate (AS) and mefloquine hydrochloride (MQ) in fixed-dose combination tablets, according to ICH guidelines. The chromatographic separation was carried out on an XBridge C18 (250 x 4.6 mm i.d., 5 µm particle size, Waters) analytical column. The mobile phase included a 0.05 M monobasic potassium phosphate buffer (pH adjusted to 3.0 with phosphoric acid) and acetonitrile (50 + 50, v/v). The flow rate was 1.0 mL/min, and the run time was 13 minutes. A dual-wavelength approach was employed: AS detection was performed at 210 nm and MQ was detected at 283 nm, using a diode array detector. Stability of sample solutions was evaluated for 8 hours after preparation, during which time the solutions remained stable. Youden's test was employed to evaluate robustness. The method proved to be linear (r²>0.99), precise (RSD<2.0%), accurate, selective, and robust, proving to be appropriate for routine drug quality control analysis.

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