New Poly Vinyl Chloride Ion Selective Electrode for Potentiometric Analysis of Propranolol in its Pharmaceutical Formulations and Human Fluids

New, simple, sensitive and rapid method for the determination of propranolol in the pharmaceutical preparations and human fluids. The Buildup and electrochemical response characteristics of a poly vinyl chloride (PVC) selective membrane electrode for the determination of propranolol (POP) are described in this research. The proposed electrodes was composed of propranolol-bromophenol blue as ion-exchanger and Di-butyl phthalate (DBPH) (electrode A), tris (2-ethylhexyl) phosphate (TEHP) (electrode B), and ortho-nitrophenyloctylether (ONPOE) (electrode C), as plasticizers. The slope was 50.94, 57.77, and 49.75 mV/decade for electrode A, B and C. the linear range was 5 ×10-5 – 1×10-2, 1×10-4 – 1×10-2, and 5×10-5 – 1×10-2 M, a detection limit of 4.2×10-5, 8.9×10-5, and 4.8×10-5 M, lifetime of 21, 42, and 1-day, respectively. Electrode B gives the best results, so the application of pharmaceutical and human fluids was based upon this electrode, the recovery percentage was 103, 101, 102.5, and 104 for POP tablet 10mg, tablet 40mg, urine and plasma by standard addition method, respectively.

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A New Poly (Vinyl Chloride) Matrix Membrane Electrode for Manual and Flow Injection Determination of Pilocarpine in Some Pharmaceutical Preparations

Analytical Letters ◽

10.1080/00032719408002637 ◽

1994 ◽

Vol 27 (10) ◽

pp. 1863-1874 ◽

Cited By ~ 2

Author(s):

Eman M. Elnemma

Keyword(s):

Vinyl Chloride ◽

Flow Injection ◽

Pharmaceutical Preparations ◽

Membrane Electrode ◽

Poly Vinyl Chloride ◽

Chloride Matrix

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Poly(vinyl chloride) matrix membrane electrode for the selective determination of heroin (diamorphine) in illicit powders

The Analyst ◽

10.1039/an9901500623 ◽

1990 ◽

Vol 115 (5) ◽

pp. 623 ◽

Cited By ~ 10

Author(s):

Saad S. M. Hassan ◽

Marawan A. Hamada

Keyword(s):

Vinyl Chloride ◽

Membrane Electrode ◽

Selective Determination ◽

Poly Vinyl Chloride ◽

Chloride Matrix

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Simple and extraction-free spectrophotometric methods for risperidone in pure form and in dosage forms

Chemical Industry and Chemical Engineering Quarterly ◽

10.2298/ciceq110824046d ◽

2013 ◽

Vol 19 (1) ◽

pp. 121-128 ◽

Cited By ~ 1

Author(s):

Hemavathi Deepakumari ◽

Shiramahally Mallegowda ◽

Kanakapura Vinay ◽

Hosakere Revanasiddappa

Keyword(s):

Limit Of Detection ◽

Ion Pairs ◽

Pharmaceutical Preparations ◽

Reference Method ◽

Standard Addition ◽

Bromophenol Blue ◽

Phenol Red ◽

Spectrophotometric Methods ◽

Accuracy And Precision

Two simple, sensitive and extraction-free spectrophotometric methods are described for the estimation of risperidone (RSP) in both pure and in pharmaceutical preparations. The proposed methods are based on the formation of ion-pair complex between RSP and the dyes, bromophenol blue (BPB) in method A and Phenol red (PR) in method B at room temperature to form yellow colored products which show maximum absorbance at 410 and at 400 nm in methods A and B, respectively. Beer's law was obeyed in the concentration range of 0.5-10 and 0.5-25 ?g mL-1 in methods A and B with apparent molar absorptivities of 3.43 ? 104 and 0.85 ? 104 L moL-1 cm-1, respectively. The limit of detection for method A is found to be 0.0056 and for method B is 0.132 ?g mL-1. The composition of the ion-pairs was established by Job?s method and it was found to be 1:1 for both the methods A and B. The proposed methods have been applied successfully to the determination of RSP in pharmaceutical preparations. The results were statistically compared with those of a reference method by applying the Student?s t-test and F-test. The methods developed were validated for accuracy and precision by performing recovery experiments via standard addition technique.

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