scholarly journals Can etanercept be an option in management of recurrent steroid-dependent erythema nodosum leprosum? A retrospective study of six patients

2021 ◽  
Vol 0 ◽  
pp. 1-4
Author(s):  
Mukesh K. Sahani ◽  
Dinesh P. Asati ◽  
Maninder Kaur ◽  
Suman Patra
Keyword(s):  
Retrospective Study ◽  
Erythema Nodosum ◽  
Erythema Nodosum Leprosum ◽  
Steroid Dependent

scholarly journals A retrospective study of the severe and uncommon variants of erythema nodosum leprosum at a tertiary health center in central India

2019 ◽  
Vol 8 (1) ◽  
pp. 29 ◽  
Author(s):  
Pritica Debnath ◽  
VaishaliH Wankhade ◽  
RajeshPratap Singh ◽  
Gitesh Sawatkar ◽  
DharitriMukund Bhat
Keyword(s):  
Retrospective Study ◽  
Health Center ◽  
Erythema Nodosum ◽  
Central India ◽  
Erythema Nodosum Leprosum

Pediatric Leprosy Profile in the Postelimination Era: A Study from Surabaya, Indonesia

2022 ◽  
Author(s):  
Cita Prakoeswa ◽  
Novianti Reza ◽  
Medhi Alinda ◽  
M. Listiawan ◽  
Hok Bing Thio ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Erythema Nodosum ◽  
Elimination Rate ◽  
Mycobacterium Leprae ◽  
Tertiary Hospital ◽  
Disease Prevalence ◽  
Erythema Nodosum Leprosum ◽  
Common Problems ◽  
Endemic Areas ◽  
Frequent Exposure

Children who live in leprosy-endemic areas are susceptible to infection due to early and frequent exposure to Mycobacterium leprae. Indonesia is on the verge of eliminating this disease (prevalence rate < 1/10,000 population), but pediatric leprosy continues to occur in low-endemic areas. This study aimed to evaluate pediatric leprosy over a decade in a tertiary hospital in Surabaya, Indonesia. A retrospective study of leprosy in children under 15 years old between 2010 and 2019 was conducted in the Morbus Hansen Division, Outpatient Clinic at Dr. Soetomo Hospital in Surabaya, Indonesia. Seventy pediatric leprosy cases were identified between 2010 and 2019, consisting of 58 multibacillary (MB)-type cases and 12 paucibacillary (PB)-type cases. Slit skin smear (SSS) was positive in 26 cases. There were two cases of grade-2 disability and 15 cases of leprosy reaction (erythema nodosum leprosum) in children at the time of diagnosis. There was an insignificant decline in the number of pediatric leprosy cases in the last 10 years. Cases and disabilities in children were found in some leprosy pocket areas even though the national elimination rate has been achieved. MB infections, disability, and treatment defaults were common problems in pediatric leprosy.

scholarly journals Our experience of the use of thalidomide in the steroid-dependent severe erythema nodosum leprosum

2009 ◽  
Vol 75 (2) ◽  
pp. 189 ◽  
Author(s):  
NidhiS Chaudhry ◽  
SwapnilR Rath ◽  
Vishalakshi Visvanath ◽  
RG Torsekar
Keyword(s):  
Erythema Nodosum ◽  
Erythema Nodosum Leprosum ◽  
Steroid Dependent

scholarly journals A Retrospective Study: Epidemiology, Onset, and Duration of Erythema Nodosum Leprosum in Surabaya, Indonesia

2021 ◽  
Vol 33 (1) ◽  
pp. 8
Author(s):  
Cindy Fransisca ◽  
Iskandar Zulkarnain ◽  
Evy Ervianti ◽  
Damayanti Damayanti ◽  
Maylita Sari ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Retrospective Study ◽  
Erythema Nodosum ◽  
First Year ◽  
Erythema Nodosum Leprosum ◽  
Regular Control ◽  
Leprosy Patients ◽  
Multibacillary Leprosy

Background: Erythema nodosum leprosum (ENL) has a chronic and recurrent nature which could reduce patient’s quality of life in addition to the onset of ENL that occurs before, during, or after multidrug treatment, further emphasizing the importance of regular control and education.Purpose:This study aimed to evaluate the epidemiology, onset, duration, and recurrence of ENL. Methods:Data from medical records were obtained for a 3-year retrospective study of multibacillary leprosy patients at the Leprosy Division of the Dermatology and Venereology Outpatient Department, Dr. Soetomo General Hospital Surabaya, with a minimum of 2–5 years follow-up period.Result:The prevalence of  ENL continued to increase almost every year especially in 2017 (32% in 2015; 32% in 2016; and 36% in 2017). ENL most often occurs during the first year of multi-drug therapy (MDT) administration followed by after the release from treatment (RFT) with the latest onset occurring 4 years after RFT. The majority of patients experienced chronic and recurrent reactions with the longest reactions lasting up to 4.5 years (55 months). Conclusion:Knowledge about the onset, duration, and recurrences of ENL are essential, and strict supervision for routine control shall be encouraged to increase the patients’ compliance so as to increase their quality of life.

scholarly journals Retrospective study of the morbidity associated with Erythema Nodosum Leprosum in Brazilian leprosy patients

2019 ◽  
Vol 90 (1) ◽  
pp. 68-77
Author(s):  
Diana Neves ◽  
Anna Maria Sales ◽  
José Augusto Da Costa Nery ◽  
Ximena Illarramendi ◽  
Rogério Valls De Souza ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Erythema Nodosum ◽  
Erythema Nodosum Leprosum ◽  
Leprosy Patients

scholarly journals Pentoxifylline therapy for patients with type 2 leprosy reactions: erythema nodosum leprosum in steroid-dependent cases

2021 ◽  
Vol 97 (1) ◽  
pp. 46-53
Author(s):  
Khairuddin Djawad
Keyword(s):  
Peripheral Nerves ◽  
Erythema Nodosum ◽  
Middle Finger ◽  
Erythema Nodosum Leprosum ◽  
Steroid Dependent ◽  
Tingling Sensation ◽  
Membrane Type

Introduction. Morbus Hansen is the infectious disease which causes by bacilli intracellular Mycobacterium leprae which mainly affects the skin and peripheral nerves. The leprosy reaction is an episode an immunologically mediated episode of acute or subacute inflammation which affecting skin; nerve; mucous membrane. Type 2 reactions can be last for months and risk of developing dependence on steroids. Pentoxifylline (PTX) works to hampers the production TNF in vitro and in vivo; are an alternative for ENL treatment. Case Report. One case was reported in a male aged 28 years with complaints of recurring red bumps accompanied by fever and pain. Discussion. On physical examination obtained erythema nodosum; with impaired sensibility in the left leg. The patient experienced improvement after being given therapy of neurodex/24 hours/oral; rifampicin 600 mg; ofloxacin 400 mg; minocycline 100 mg which given 3x for a week; and combination therapy to treat the Leprosy reaction given the combination of methylprednisolone 16mg (3-2-0) and Pentoxifylline 400 mg/8 hours/oral. Conclusion. In the 21 day of treatment; the redness lump improved in the middle finger and left arm was gone. No new reddish bumps appeared and less tingling sensation.

scholarly journals Profil Penderita Morbus Hansen (MH) di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado Periode Januari – Desember 2013

e-CliniC ◽  
2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Andiswati Desrina ◽  
Grace M. Kapantow ◽  
Renate T. Kandou
Keyword(s):  
Retrospective Study ◽  
Physical Disability ◽  
Erythema Nodosum ◽  
Multidrug Therapy ◽  
Erythema Nodosum Leprosum ◽  
Reversal Reaction

Abstract: Morbus Hansen (MH) is still a public, social, and rehabilitation problems due to the physical disability resulted from delayed or inadequate treatment. This study was aimed to obtain the profile of MH patients at the Dermatovenerology clinic, Prof. Dr. R. D. Kandou Hospital Manado in the period of January to December 2013. This was a descriptive and retrospective study. The results showed that there were 98 MH patients consisting of 69 males (70.4%) and 29 females (29,6%). The majority of patients were 25-44 years old (47.0%) with multibacillary type (93.9%). Most patients did not show lepra reaction (67.3%); erythema nodosum leprosum (ENL) reaction was found in 29.6% of patients, and reversal reaction in 3.1% of patients. As many of 29.6% had been treated with multidrug therapy (MDT), and 10.2% did not, meanwhile, 60,2% of patients did not have any data of treatment. In conclusion, the majority of MH patients at the Dermatovenerology clinic, Prof. Dr. R. D. Kandou Hospital Manado in the period of January to December 2013 were males, aged 25-44 years, had multibacillary type with ENL reaction, and had been treated with MDT.Keywords: Morbus Hansen profile Abstrak: Morbus Hansen (MH) masih merupakan masalah kesehatan, sosial, dan rehabilitasi oleh karena kecacatan fisik yang terjadi akibat pengobatan yang terlambat atau tidak memadai. Penelitian ini bertujuan untuk mengetahui profil penderita MH di Poliklinik Kulit dan Kelamin RSUP Prof. R. D Kandou Manado periode Januari-Desember 2013. Jenis penelitian ialah deskrip-tif retrospektif. Hasil penelitian mendapatkan 98 penderita MH (6,72%) dari total 1457 pasien, terdiri dari 69 laki-laki (70,4%) dan 29 perempuan (29,6%). Mayoritas penderita berada pada rentang usia 25-44 tahun (47,0%) dengan tipe MH multibasiler (93,9%). Pada sebagian besar pen-derita tidak didapatkan reaksi lepra (67,3%); reaksi erythema nodosum leprosum (ENL) didapatkan pada 29,6% penderita dan reaksi reversal pada 3,1% penderita. Mengenai riwayat pengobatan, sebesar 29,6% telah mendapat pengobatan multidrug therapy (MDT) sebelumnya dan 10,2% belum pernah mendapatkan pengobatan MDT, namun sebesar 60,2% penderita tidak memiliki data pengobatan. Simpulan penelitian ini ialah mayoritas penderita MH di Poliklinik Kulit dan Kelamin RSUP Prof. R. D Kandou Manado periode Januari-Desember 2013 berjenis kelamin laki-laki, usia 25-44 tahun, tipe MH multibasiler, dengan reaksi ENL, dan pernah mendapat pengobatan MDT.Kata kunci: profil Morbus Hansen

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