Bibliometric analysis of the top-100 most cited articles on the radiosurgical management of cerebral arteriovenous malformation

Background: Radiosurgery is an effective, alternative treatment modality in managing patients with cerebral arteriovenous malformations (AVMs). The present study aims to highlight the scholarly impact of the top-100 most cited articles on the radiosurgical management of AVMs. Methods: A title-specific search using the keyword “arteriovenous malformation” was conducted in the Scopus database. The outcome of the search was rearranged based on the citations count. Articles were categorized into four entities; clinical, gamma knife radiosurgery, linear accelerator (LINAC) radiosurgery, and proton beam radiosurgery. The exclusion criteria were applied to spinal or non-intracranial AVM, conference papers, non-English articles predominantly discussing the endovascular or microsurgical management. Results: The top-100 articles on the radiosurgical management of AVM were published between 1972 and 2016. Approximately one-third of the publications were produced between 1995 and 2000. The average citations per year for all papers were seven. The most-studied entity was pertinent to the clinical application of gamma knife radiosurgery in AVM (68%). The United States was the most active country in studying the radiosurgical application in AVM. The Journal of Neurosurgery published approximately one-third of the most-cited articles in the list. The top-3 most contributing authors, publishing 80% of articles in the list, were Lunsford et al. Conclusion: The radiosurgical management of AVMs evolved significantly throughout the years. Identifications of the publication trends facilitate the acquisition of evidence-based articles for authors investigating various radiosurgical techniques in the treatment of AVMs.

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Gamma knife radiosurgery for cerebral arteriovenous malformations in children/adolescents and adults. Part II: Differences in obliteration rates, treatment-obliteration intervals, and prognostic factors

Yearbook of Neurology and Neurosurgery ◽

10.1016/s0513-5117(08)70168-6 ◽

2007 ◽

Vol 2007 ◽

pp. 242

Author(s):

W.B. Gormley

Keyword(s):

Prognostic Factors ◽

Gamma Knife ◽

Arteriovenous Malformations ◽

Gamma Knife Radiosurgery ◽

Cerebral Arteriovenous Malformations ◽

Adolescents And Adults

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P03.08 Large cerebral arteriovenous malformations management with Volume-staged gamma knife radiosurgery

Neuro-Oncology ◽

10.1093/neuonc/noz126.089 ◽

2019 ◽

Vol 21 (Supplement_3) ◽

pp. iii26-iii26

Author(s):

R M Emad Eldin ◽

W A Reda ◽

A M El-Shehaby ◽

K Abdel Karim ◽

A Nabeel ◽

...

Keyword(s):

Gamma Knife ◽

Arteriovenous Malformations ◽

Gamma Knife Radiosurgery ◽

Cerebral Arteriovenous Malformations ◽

Factors Affecting ◽

Prescription Dose ◽

The Mean ◽

Cerebral Avms ◽

Grade 3

Abstract BACKGROUND Large cerebral arteriovenous malformations (AVM) pose a management dilemma because of the limited success of any single treatment modality by itself. Surgery alone is associated with significant morbidity and mortality. Similarly, embolization alone has limited efficacy. Volume-staged gamma knife radiosurgery (VSGR) has been developed for the treatment of large AVMs, to increase the efficacy and improve safety of treatment of these lesions. The aim of the study was to assess the efficacy and safety of VSGR technique for the treatment of large cerebral AVMs. METHODS The study included patients treated by VSGR between May 2009 and July 2015. All cases had large AVMs (>10 cc). These were 29 patients. RESULTS Twenty-four patients completed radiographic follow up with 15 obliteration cases (62.5%). There was a total of 56 sessions performed. The mean AVM volume was 16 cc (10.1–29.3 cc). The mean prescription dose was 18 Gy (14–22 Gy). The mean follow up duration was 43 months (21–73 months). One patient died during follow up from unrelated cause. Two cases suffered haemorrhage during follow up. Symptomatic edema developed in 5 (17%) patients. The factors affecting obliteration were smaller total volume, higher dose/stage, non-deep location, compact AVM, AVM score less than 3, >18 Gy dose and <15 cc total volume. The factors affecting symptomatic edema were smaller total volume and shorter time between first and last sessions (p 0.012). T2 image changes were affected by SM grade 3 or more (p 0.013) and AVM score 3 or more (p 0.014). CONCLUSION VSGR provides an effective and safe treatment option for large cerebral AVMs. Smaller AVM volume is associated with higher obliteration rate.

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Resolution of hemifacial spasm after successful treatment of posterior fossa arteriovenous malformation by gamma knife radiosurgery

Clinical Neurology and Neurosurgery ◽

10.1016/j.clineuro.2014.01.014 ◽

2014 ◽

Vol 119 ◽

pp. 121-124

Author(s):

Yaşar Bayri ◽

Bahattin Tanrıkulu ◽

Ulaş Yener ◽

Aşkın Şeker ◽

Türker Kılıç

Keyword(s):

Arteriovenous Malformation ◽

Posterior Fossa ◽

Gamma Knife ◽

Successful Treatment ◽

Hemifacial Spasm ◽

Gamma Knife Radiosurgery

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Gamma Knife Radiosurgery for Cerebral Arteriovenous Malformations

Surgery for Cerebral Stroke ◽

10.2335/scs1987.27.4_241 ◽

1999 ◽

Vol 27 (4) ◽

pp. 241-247 ◽

Cited By ~ 1

Author(s):

Masaaki YAMAMOTO ◽

Takayuki TANAKA ◽

Nagatoshi BOKU ◽

Seiji FUKUOKA ◽

Hiromichi HOSODA ◽

...

Keyword(s):

Gamma Knife ◽

Arteriovenous Malformations ◽

Gamma Knife Radiosurgery ◽

Cerebral Arteriovenous Malformations

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Combined Embolization and Gamma Knife Radiosurgery for Cerebral Arteriovenous Malformations

Acta Radiologica ◽

10.1177/028418519303400614 ◽

1993 ◽

Vol 34 (6) ◽

pp. 600-606 ◽

Cited By ~ 28

Author(s):

W. Y. Guo ◽

G. Wikholm ◽

B. Karlsson ◽

C. Lindquist ◽

P. Svendsen ◽

...

Keyword(s):

Gamma Knife ◽

Arteriovenous Malformations ◽

Combined Treatment ◽

Time Lag ◽

Gamma Knife Radiosurgery ◽

Cerebral Arteriovenous Malformations ◽

Neurologic Deficits ◽

Feeding Vessels ◽

Grade Iii

In a study of 46 patients with cerebral arteriovenous malformations (AVMs) the value of combining embolization and gamma knife radiosurgery was assessed. In 35 patients with large grade III to V AVMs (Spetzler-Martin system) staged combined treatment was planned. In 11 patients, radiosurgery complemented embolization for a residual AVM. The number of embolization sessions ranged from 1 to 7 (median 2). Twenty-six patients needed multiple embolization sessions. In 28 patients the grade of AVMs decreased as a result of embolization. In 16 patients collateral feeding vessels developed after embolization which made delineation of the residual nidus difficult. The time lag between the last embolization and radiosurgery ranged from 1 to 24 months (median 4). Nineteen of 35 large grade III to V AVMs were possible to treat by radiosurgery following embolization. In the 46 patients complications occurred in 9 from embolization and in 2 from radiosurgery. Two patients had transient and 9 had permanent neurologic deficits. It is concluded that embolization facilitates radiosurgery for some large AVMs and therefore this combined treatment has a role in the management of AVMs.

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Endovascular Treatment Accounts for a Change in Brain Arteriovenous Malformation Natural History Risk

Interventional Neuroradiology ◽

10.1177/159101991001600203 ◽

2010 ◽

Vol 16 (2) ◽

pp. 127-132 ◽

Cited By ~ 20

Author(s):

X. Lv ◽

Z. Wu ◽

C. Jiang ◽

Y. Li ◽

X. Yang ◽

...

Keyword(s):

Arteriovenous Malformation ◽

Gamma Knife ◽

Gamma Knife Radiosurgery ◽

Venous Drainage ◽

Endovascular Embolization ◽

Adjusted Relative Risk ◽

Brain Arteriovenous Malformation ◽

Kaplan Meier ◽

Complete Obliteration ◽

Risk Of Hemorrhage

This study estimated the risk and rates of intracranial hemorrhage (ICH) in patients harboring brain arteriovenous malformation (BAVM) after endovascular embolization. One hundred and forty-four consecutive patients with BAVM treated with endovascular embolization between 1998 and 2003 were retrospectively reviewed. The risk of ICH subsequent to endovascular embolization was studied using Kaplan-Meier curves. We reviewed 144 patients with BAVM treated with endovascular embolization. Two hundred and sixty-nine procedures were performed, 69 were performed with silk sutures, 18 with coils, 137 with NBCA and 36 with Onyx18. Twenty-three (16.0%) patients were treated with additional gamma-knife radiosurgery and one (0.7%) with additional surgical AVM excision. Complete obliteration of BAVMs was achieved in 20 patients (13.9%). During a mean follow-up of 5.9 years for the ICH group and 6.9 years for the non-ICH group, hemorrhages occurred in 11 (17.7%) of the ICH patients and in nine (11%) of the non-ICH group (p>0.1). The annual risk of hemorrhage was 3.0% and 1.6%, respectively. In the multivariate regression model, the adjusted relative risk (RR) for hemorrhage at initial presentation was 1.6 (95% CI 1.2–3.2; p>0.1). Deep venous drainage, male sex, age or AVM size were not significantly associated with subsequent hemorrhage. ICH and non-ICH groups did not differ in progression to subsequent ICH after endovascular embolization (log-rank X2 = 1.339, p>0.1) in survival analyses. The overall annual hemorrhage risk for all patients after endovascular embolization was 2.1%. Endovascular embolization alone or combined with gamma-knife radiosurgery or surgical treatment are able to decrease ICH occurrence compared to abstention.

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