Hemispherotomy in the surgical treatment of severe symptomatic epilepsy

In past, cavernoma was frequently cause of symptomatic epilepsy without pathological substrate. We present the group of the patient (32) whose illness were presented by epilepsy, and who were treated in Institute for Neurosurgery from 1998 to 2003. There is the good correlation between presentation of epilepsy and largeness of the cavernoma (Phi 0.683). In 22 patients the epilepsy was controlled by medicaments, and in other the seizures were uncontrolled. Cavernoma initially presented with seizures had no inclination for massive intralesional or parenhimal bleeding. After surgical extirpation of lesion, there was good outcome during the following period of 3 years.

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Management of symptomatic epilepsy after surgery due to drug resistance

INTERNATIONAL NEUROLOGICAL JOURNAL ◽

10.22141/2224-0713.17.3.2021.231571 ◽

2021 ◽

Vol 17 (3) ◽

pp. 18-24

Author(s):

A.Ye. Dubenko ◽

M.V. Naboka

Keyword(s):

Drug Resistance ◽

Surgical Treatment ◽

Drug Treatment ◽

Clinical Situation ◽

Evidence Base ◽

Symptomatic Epilepsy ◽

Drug Resistant Epilepsy ◽

One Year ◽

Ilae Classification

The issue of managing patients who were operated due to drug resistance has not been accomplished not only in Ukraine, but throughout the world. But these patients exist, their number is growing, and the neurologists who observe them need a direct understanding of this process. Nowadays, there is no enough evidence base to substantiate rational recommendations regarding the post-surgical drug treatment. Despite the fact that the International League Against Epilepsy (ILAE) classification and the classification previously proposed by J. Engel Jr have many headings that indicate the improvement of patients and possible improvement in their quality of life, the treatment that has achieved seizure control can be considered successful only in patients who meet qualification point 1 according to the ILAE classification or IA according to the Engel classification, and only those who meet these criteria for at least one year. This understanding is very important when choosing further therapeutic management. Taking into account the fact that after surgical treatment the drug resistance should be overcome, further drug treatment should be carried out in the same way as in patients without drug resistant epilepsy. The issue of managing people with epilepsy who received surgical treatment due to drug resistance requires further studies, especially in the context of an increase in the number of such patients. The authors indicate that all the questions and aspects that were presented in the work are controversial and can be adjusted depending on the clinical situation.

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Surgical treatment of symptomatic epilepsy in patients with brain cavernomas

Ukrainian Neurosurgical Journal ◽

10.25305/unj.54144 ◽

2013 ◽

Vol 0 (3) ◽

pp. 25-29

Author(s):

Vitaliy Tsymbaliuk ◽

Orest Tsimeyko ◽

Leonid Yakovenko ◽

Mykhaylo Kostiuk ◽

Kostyantyn Kostiuk

Keyword(s):

Surgical Treatment ◽

Symptomatic Epilepsy

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Functional hemispherotomy in the treatment of drug-resistant epilepsy: a clinical case

Epilepsia and paroxyzmal conditions ◽

10.17749/2077-8333.2018.10.4.054-060 ◽

2019 ◽

Vol 10 (4) ◽

pp. 54-60

Author(s):

A. A. Sufianov ◽

R. T. Deniel ◽

S. Zh. Stefanov ◽

G. Z. Sufianova ◽

A. S. Orlov ◽

...

Keyword(s):

Early Childhood ◽

Surgical Treatment ◽

Female Patient ◽

Clinical Case ◽

Practical Interest ◽

Epileptic Seizures ◽

Drug Resistant ◽

Symptomatic Epilepsy ◽

Great Practical Interest ◽

Drug Resistant Epilepsy

Though brain hemiatrophy is not among the leading causes of symptomatic epilepsy; the problem remains important and is of great practical interest to neurologists and neurosurgeons in Russia. In this article; we present an example of successful surgical treatment of Dyke-Davidoff-Masson syndrome. Here; functional hemispherotomy was performed in a 22 years old female patient; as a result; the occurrence and intensity of epileptic seizures decreased. This clinical case provides hope for this procedure to show even better results if performed in early childhood.

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F117. Efficacy of intraoperative electrocorticography: Long-term results of surgical treatment of symptomatic epilepsy

Clinical Neurophysiology ◽

10.1016/j.clinph.2018.04.280 ◽

2018 ◽

Vol 129 ◽

pp. e110-e111

Author(s):

Nastasia Arkhipova ◽

Yelena Marchenko ◽

Irina Kostenko ◽

Aleksey Ulitin ◽

Malik Tastanbekov ◽

...

Keyword(s):

Surgical Treatment ◽

Long Term Results ◽

Symptomatic Epilepsy

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ENDOSCOPIC TREATMENT OF ARACHNOID CYSTS OF THE MIDDLE CRANIAL FOSSA IN CHILDREN

10.25005/2074-0581-2020-22-3-390-397 ◽

2020 ◽

pp. 390-397

Author(s):

R.A. SUFIANOV ◽

◽

M.M. ABDUMAZHITOVA ◽

R.R. RUSTAMOV ◽

A.A. SUFIANOV ◽

...

Keyword(s):

Surgical Treatment ◽

Endoscopic Treatment ◽

Middle Cranial Fossa ◽

Speech Development ◽

Arachnoid Cysts ◽

Total Efficiency ◽

Symptomatic Epilepsy ◽

Cranial Fossa ◽

The Right ◽

Observation Period

Objective: Improvement of the results and effectiveness of endoscopic treatment for arachnoid cysts of the middle cranial fossa (AC MCF) in children. Methods: At the Federal Center for Neurosurgery of Tyumen 65 patients with AC MCF were operated from 2012 to 2018 by endoscopic cystocisternostomy (ECCS). Patients age ranged from one month up to 17 years. Children under 3 years old were – 32 (49%). Hypertensive symptoms were in 26 (40%); delayed speech development in 20 (31%); symptomatic epilepsy in 12 (18.5%); pathology of the ocular fundus was in 5 (7.7%). Associated abnormalities were in 19 (29%). All patients underwent CT and/or MRI. In 46 (71%) patients, cysts were located on the right, in 13 (20%) on the left and 6 (9%) bilateral. The displacement of the middle structures was diagnosed in 45 (69%). According to the Galassi classification: type II was in 20 (31%), type III – in 45 (69%) patients. The average volume of AC MCF before the operation was 181±18.6 cm3. All 65 patients underwent ECCS: a miniature neuroendoscope KarlStorz – Endoskop 11576 KF/KG was used in 47 patients, and a standard rigid endoscope LOTTA, «Gaab I scope» or flexible video scope was used in 18 patients. Results: The postoperative observation period ranged from 1 year to 8 years. The volume of cysts after surgery averaged 124.8±17.2 cm3. On average, the volume of cysts decreased by 58.2±13.5 cm3. The total efficiency of ECCS in 65 patients with AC MCF reached 81.5% of cases. Relapse was noted in 14 patients (22%). The period of recurrence ranged from 1 month to 81 month. Recurrence was in 71% of children under the age of 3 years. There was a correlation between repeated interventions and age. Children under 3 years of age have the efficiency of surgical treatment at 68.8% than in children over 3 years old – 93.8% (p≤0.01). The results of surgical treatment, depending on the endoscope used, were statistically unreliable, because when using Karl Storz – Endoskop 11576 KF/KG the total efficiency was 81%, and when using LOTTA, «Gaab I scope» or a flexible video scope – 84%. Complications in the postoperative period occurred in 6 (9%) children. Conclusions: The effectiveness of ECCS in 65 children with AC MCF reached 81.5% of cases. The effectiveness of ECCS in children under 3 years of age was 68.7%, and 93.7% in children older than 3 years. Keywords: Middle cranial fossa , arachnoid cysts in children, intracranial cyst, endoscopic treatment, endoscopic cystocisternostomy.

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Human Stapes Crura: Normal Ultrastructure. Scanning Electron Microscopic Findings

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100116267 ◽

1975 ◽

Vol 33 ◽

pp. 528-529

Author(s):

M.D. Graham

Keyword(s):

Electron Microscope ◽

Surgical Treatment ◽

Scanning Electron Microscope ◽

Osmic Acid ◽

Human Cadaver ◽

Electron Microscopic ◽

Scanning Electron Microscopic ◽

Normal Human ◽

Microscopic Findings ◽

Scanning Electron

The recent development of the scanning electron microscope has added great impetus to the study of ultrastructural details of normal human ossicles. A thorough description of the ultrastructure of the human ossicles is required in order to determine changes associated with disease processes following medical or surgical treatment.Human stapes crura were obtained at the time of surgery for clinical otosclerosis and from human cadaver material. The specimens to be examined by the scanning electron microscope were fixed immediately in the operating room in a cold phosphate buffered 2% gluteraldehyde solution, washed with Ringers, post fixed in cold 1% osmic acid and dehydrated in graded alcohol. Specimens were transferred from alcohol to a series of increasing concentrations of ethyl alcohol and amyl acetate. The tissue was then critical point dried, secured to aluminum stubs and coated with gold, approximately 150A thick on a rotating stage in a vacuum evaporator. The specimens were then studied with the Kent-Cambridge S4-10 Scanning Electron Microscope at an accelerating voltage of 20KV.

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