Cognitive evoked potentials in the diagnosis of post-concussion syndrome due to blast mild traumatic brain injury

Hostilities in the East of Ukraine are characterized by the use of new weapons, including rocket artillery, rocket-propelled grenades and landmines. This has led to an increase in the number of victims with blast mild traumatic brain injury (BMTBI) and the need to provide them with effective assistance and rehabilitation. An important task is to improve the BMTBI diagnosis by specifying the objective criteria for structural and functional disorders of the central nervous system. This will improve the prognosis of the course of BMTBI in the injured and the treatment program, including personalized, to prevent the development of persistent neurological deficit. Objective: to investigate the possibilities of the cognitive evoked potentials (CEP) method for the objective diagnosis of cognitive disorders in post-concussion syndrome (PCS) BMTBI. Materials and methods. The study involved 115 men with PCS (main group) and 30 healthy individuals (control group). The cognitive functions of the study participants were studied using the questionnaire "Cicerone". The neurophysiological method for assessing the functional state of the brain involved the registration of CEP, event-related (P300 CEP). Results. The selection of a subgroup of patients with PCS, characterized by a predominance of cognitive impairments, allowed us to trace the relationship between the results of neurophysiological studies with the cognitive indicators of patients with BMTBI. P300 latency indices are inversely proportional to cognitive assessment the questionnaire "Cicerone" and statistically significantly depend on the severity of cognitive impairment. Conclusions. The CEP P300 method can be an effective means of objectifying the degree of cognitive impairment in patients with PCS due to BMTBI.

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Hyperbaric oxygen therapy for persistent post-concussion syndrome following mild traumatic brain injury

Cochrane Database of Systematic Reviews ◽

10.1002/14651858.cd012727 ◽

2017 ◽

Author(s):

Yusuke Tsutsumi ◽

Ikuyo Tsutsumi ◽

Yasushi Tsujimoto ◽

Sei Takahashi ◽

Asuka Tsuchiya ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Hyperbaric Oxygen ◽

Mild Traumatic Brain Injury ◽

Hyperbaric Oxygen Therapy ◽

Oxygen Therapy ◽

Post Concussion Syndrome

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Elevated levels of serum, but not salivary, brain-derived neurotrophic factor following mild traumatic brain injury in collegiate athletes post return-to-play

Journal of Concussion ◽

10.1177/2059700219894108 ◽

2019 ◽

Vol 3 ◽

pp. 205970021989410

Author(s):

Taylor R Susa ◽

Ryan D Brandt ◽

Keara J Kangas ◽

Catherine E Bammert ◽

Erich N Ottem ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Neurotrophic Factor ◽

Collegiate Athletes ◽

Brain Derived Neurotrophic Factor ◽

Return To Play ◽

Control Group ◽

The Relationship ◽

Serum Bdnf

Brain-derived neurotrophic factor (BDNF) helps restore neuronal function following mild traumatic brain injury. BDNF levels can be obtained in blood serum and more recently in saliva. However, the relationship between serum and salivary BDNF is poorly understood—especially in relation to alterations in BDNF levels following mild traumatic brain injury. In this study, serum and salivary BDNF were collected from a sample of 42 collegiate student athletes. Half of the participants were recently cleared by a physician and/or an athletic trainer to return-to-play after experiencing a sports-related concussion. The other half had not experienced a concussion within the past year and were matched by age, sex, sport, and time of sample. Results suggest that incidences of depression, anxiety, and stress were all elevated in the concussion group, relative to the control participants. When controlling for stress-related negative affect, serum BDNF was elevated in the concussion group. However, there was no difference in salivary BDNF. Serum and salivary BDNF were uncorrelated across the entire sample. Yet, these measures of BDNF were correlated in the concussion group, but not the control group. In sum, serum BDNF is elevated in concussion post return-to-play; however, further research is needed to explore the utility of salivary BDNF following concussion.

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Diagnostic Approach to Traumatic Axonal Injury of the Spinothalamic Tract in Individual Patients with Mild Traumatic Brain Injury

Diagnostics ◽

10.3390/diagnostics9040199 ◽

2019 ◽

Vol 9 (4) ◽

pp. 199 ◽

Cited By ~ 3

Author(s):

Jang ◽

Lee

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Axonal Injury ◽

Control Group ◽

Central Pain ◽

Traumatic Axonal Injury ◽

Spinothalamic Tract ◽

Statistical Comparison ◽

Control Subjects

Objectives: We investigated an approach for the diagnosis of traumatic axonal injury (TAI) of the spinothalamic tract (STT) that was based on diffusion tensor tractography (DTT) results and a statistical comparison of individual patients who showed central pain following mild traumatic brain injury (mTBI) with the control group. Methods: Five right-handed female patients in their forties and with central pain following mTBI and 12 age-, sex-, and handedness-matched healthy control subjects were recruited. After DTT reconstruction of the STT, we analyzed the STT in terms of three DTT parameters (fractional anisotropy (FA), mean diffusivity (MD), and fiber number (FN)) and its configuration (narrowing and tearing). To assess narrowing, we determined the area of the STT on an axial slice of the subcortical white matter. Results: the FN values were significantly lower in at least one hemisphere of each patient when compared to those of the control subjects (p < 0.05). Significant decrements from the STT area in the control group were observed in at least one hemisphere of each patient (p < 0.05). Regarding configurational analysis, the STT showed narrowing and/or partial tearing in at least one hemisphere of each of the five patients. Conclusions: Herein, we demonstrate a DTT-based approach for the diagnosis of TAI of the STT. The approach involves a statistical comparison between DTT parameters of individual patients who show central pain following mTBI and those of an age-, gender-, and handedness-matched control group. We think that the method described in this study can be useful in the diagnosis of TAI of the STT in individual mTBI patients.

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Links Between Mild Traumatic Brain Injury, Cognitive Impairment and Social Inference Four Years Post-Injury

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2018.08.039 ◽

2018 ◽

Vol 99 (11) ◽

pp. e140

Author(s):

Alice Theadom ◽

Kelly Jones ◽

Nicola Starkey ◽

Skye McDonald ◽

Suzanne Barker-Collo ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Cognitive Impairment ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Post Injury ◽

Social Inference

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Results of scoping review do not support mild traumatic brain injury being associated with a high incidence of chronic cognitive impairment: Commentary on McInnes et al. 2017

PLoS ONE ◽

10.1371/journal.pone.0218997 ◽

2019 ◽

Vol 14 (9) ◽

pp. e0218997 ◽

Cited By ~ 5

Author(s):

Grant L. Iverson ◽

Justin E. Karr ◽

Andrew J. Gardner ◽

Noah D. Silverberg ◽

Douglas P. Terry

Keyword(s):

Traumatic Brain Injury ◽

Cognitive Impairment ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Scoping Review ◽

High Incidence

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Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage

Neural Plasticity ◽

10.1155/2020/2174371 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Fengfang Li ◽

Liyan Lu ◽

Song’an Shang ◽

Huiyou Chen ◽

Peng Wang ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Cognitive Impairment ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Arterial Spin Labeling ◽

Spin Labeling ◽

Perfusion Magnetic Resonance Imaging ◽

The Right

Objective. The influence of cognitive impairment after mild traumatic brain injury (mTBI) on cerebral vascular perfusion has been widely concerned, yet the resting-state cerebral blood flow (CBF) connectivity alterations based on arterial spin labeling (ASL) in mild traumatic brain injury (mTBI) remain unclear. This study investigated region CBF and CBF connectivity features in acute mTBI patients, as well as the associations between CBF changes and cognitive impairment. Materials and Methods. Forty-five acute mTBI patients and 42 health controls underwent pseudocontinuous arterial spin labeling (pCASL) perfusion magnetic resonance imaging (MRI). The alterations in regional CBF and relationship between the CBF changes and cognitive impairment were detected. The ASL-CBF connectivity of the brain regions with regional CBF significant differences was also compared between two groups. Neuropsychological tests covered seven cognitive domains. Associations between the CBF changes and cognitive impairment were further investigated. Results. Compared with the healthy controls, the acute mTBI patients exhibited increased CBF in the bilateral inferior temporal gyrus (ITG) and decreased CBF in the right middle frontal gyrus (MFG), the bilateral superior frontal gyrus (SFG), and the right cerebellum posterior lobe (CPL). In the mTBI patients, significant correlations were identified between the CBF changes and cognitive impairment. Importantly, the acute mTBI patients exhibited CBF disconnections between the right CPL and right fusiform gyrus (FG) as well as bilateral ITG, between the left SFG and left middle occipital gyrus (MOG), and between the right SFG and right FG as well as right parahippocampal gyrus. Conclusion. Our results suggest that acute mTBI patients exhibit both regional CBF abnormalities and CBF connectivity deficits, which may underlie the cognitive impairment of the acute mTBI patients.

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