On the Rollout of Network Slicing in Carrier Networks: A Technology Radar

Network slicing is a powerful paradigm for network operators to support use cases with widely diverse requirements atop a common infrastructure. As 5G standards are completed, and commercial solutions mature, operators need to start thinking about how to integrate network slicing capabilities in their assets, so that customer-facing solutions can be made available in their portfolio. This integration is, however, not an easy task, due to the heterogeneity of assets that typically exist in carrier networks. In this regard, 5G commercial networks may consist of a number of domains, each with a different technological pace, and built out of products from multiple vendors, including legacy network devices and functions. These multi-technology, multi-vendor and brownfield features constitute a challenge for the operator, which is required to deploy and operate slices across all these domains in order to satisfy the end-to-end nature of the services hosted by these slices. In this context, the only realistic option for operators is to introduce slicing capabilities progressively, following a phased approach in their roll-out. The purpose of this paper is to precisely help designing this kind of plan, by means of a technology radar. The radar identifies a set of solutions enabling network slicing on the individual domains, and classifies these solutions into four rings, each corresponding to a different timeline: (i) as-is ring, covering today’s slicing solutions; (ii) deploy ring, corresponding to solutions available in the short term; (iii) test ring, considering medium-term solutions; and (iv) explore ring, with solutions expected in the long run. This classification is done based on the technical availability of the solutions, together with the foreseen market demands. The value of this radar lies in its ability to provide a complete view of the slicing landscape with one single snapshot, by linking solutions to information that operators may use for decision making in their individual go-to-market strategies.

Momentum vs. Labour’s Bureaucracy

The creation of Corbynist organization Momentum was the way in which the wave of socialist revival in the UK tried to take an organizational form and work toward the transformation of the Labour party. The first-past-the-post system meant that the only realistic option for socialists was working within the existing mainstream left party, while at the same time developing a parallel structure to mobilize youth supporters suspicious of bureaucratic structures. However, as I argue in this article, ultimately the stubbornness of the Labour party bureaucracy used as a defensive redoubt by party centrists managed to successfully fend off attempts for deep party reforms, and once Corbyn resigned it was easy for centrists to undo the change in the internal balance of forces. The failure of the Corbyn movement in overcoming these difficulties highlights how party organization constitutes a strategic bottleneck for all transformative movements, and that the only way to reclaim existing parties is to radically reshape them as a matter of priority.

Antimicrobial Resistance Situational Analysis 2019–2020: Design and Performance for Human Health Surveillance in Uganda

Antibiotic resistance and its mechanisms have been known for over six decades, but global efforts to characterize its routine drivers have only gained momentum in the recent past. Drivers of clinical and community resistance go beyond just clinical practice, which is why one-health approaches offer the most realistic option for controlling antibiotic resistance. It is noteworthy that emergence of resistance occurs naturally in the environment, but akin to climate change, the current accelerated emergence and spread bears hallmarks of anthropomorphic influence. If left unchecked, this has the potential to undo medical and agricultural advancements of the last century. To tackle this problem, the WHO recommends that nations develop, adopt and implement strategies that track the changing trends in antibiotic resistance levels. In this article, we examine efforts and progress in developing and implementing a human health antimicrobial resistance surveillance strategy in Uganda. We do so within context of the National Action Plan for tackling antimicrobial resistance (AMR-NAP) launched in 2018. We discuss the technical milestones and progress in implementing surveillance of GLASS priority pathogens under this framework. The preliminary output of the framework is used to examine the performance as well as compare AMR and AMU surveillance data to explain observed trends. We conclude that Uganda is making progress in developing and implementing a functional AMR surveillance strategy for human health.

The Meaning of Radicalisation in Modern Social Pedagogy

The article defines radicalisation as part of the processes of modern liberation, which are recognised in the interlacement of emancipatory potential in social pedagogy and mobilisation in the theory of community development. In parallel to this, we problematise the internally divided socio-pedagogical attitude, which, on the one hand, seeks to liberate, and on the other hand, is repeatedly caught in the preservation of existing “oppressive” power relations. In doing so, we consider the concerns regarding political action as the goal of “radicalising” social pedagogy, which indicate that in social pedagogy we have internalized collaboration as a democratic “norm” of solving social and other societal issues and thus accepted it as the only formally realistic option to achieve structural change.

The Role of Mesenchymal Stem Cells (MSCs) in Veterinary Medicine and Their Use in Musculoskeletal Disorders

Regenerative medicine is a dynamically developing field of human and veterinary medicine. The animal model was most commonly used for mesenchymal stem cells (MSCs) treatment in experimental and preclinical studies with a satisfactory therapeutic effect. Year by year, the need for alternative treatments in veterinary medicine is increasing, and other applications for promising MSCs and their biological derivatives are constantly being sought. There is also an increase in demand for other methods of treating disease states, of which the classical treatment methods did not bring the desired results. Cell therapy can be a realistic option for treating human and animal diseases in the near future and therefore additional research is needed to optimize cell origins, numbers, or application methods in order to standardize the treatment process and assess its effects. The aim of the following work was to summarize available knowledge about stem cells in veterinary medicine and their possible application in the treatment of chosen musculoskeletal disorders in dogs and horses.

iPS-abgeleitete Kardiomyozyten als therapeutische Hoffnungsträger

After ischemic injury in adolescence, the human heart has only limited capacity to regenerate. The loss of cardiomyocytes is typically replaced by fibrotic scar tissue. The resulting scars reduce myocardial contractility and function. To date, the gold standard for end-stage heart disease remains a heart transplant, which is not a realistic option due to donor heart shortage. The regenerative potential of reprogrammed stem cells has the potential for a long-expected breakthrough in development of efficient therapeutic interventions.

Wind Turbine Prognosis Models Based on SCADA Data and Extreme Learning Machines

In this paper, a method to build models to monitor and evaluate the health status of wind turbines using Single-hidden Layer Feedforward Neural networks (SLFN) is presented. The models are trained using the Extreme Learning Machines (ELM) strategy. The data used is obtained from the SCADA systems, easily available in modern wind turbines. The ELM technique requires very low computational costs for the training of the models, and thus allows for the integration of a grid-search approach with parallelized instances to find out the optimal model parameters. These models can be built both individually, considering the turbines separately, or as an aggregate for the whole wind plant. The followed strategy consists in predicting a target variable using the rest of the variables of the system/subsystem, computing the error deviation from the real target variable and finally comparing high error values with a selection of alarm events for that system, therefore validating the performance of the model. The experimental results indicate that this methodology leads to the detection of mismatches in the stages of the system’s failure, thus making it possible to schedule the maintenance operation before a critical failure occurs. The simplicity of the ELM systems and the ease with which the parameters can be adjusted make it a realistic option to be implemented in wind turbine models to work in real time.

Prevention of metropolitan and railway suicide

Railway suicides account for less than 10% of all suicides and are considered a major public health issue because of their consequences for the operation of the transportation system and their deteriorating impact on staff and bystanders. Behaviour patterns include jumping, lying, wandering, and deviant behaviour prodromal to the attempt. Case fatality is 90% of all attempts (railway) or circa 60% (metro). Victims are predominately male and young, with a median age stratum in the range of 25–34 years. The weekly distribution shows a peak at the beginning of the week and a low on weekends. Preventive measures include inhibiting access to the track (e.g. barriers at places of advanced risk or surveillance systems), inhibiting media coverage, or education of gatekeepers to increase awareness, and skilfulness in contact with vulnerable subjects. Railway suicide prevention is a realistic option; however, further research is urgently needed.

Adipose Tissue and Endocrine-Disrupting Chemicals: Does Sex Matter?

Obesity and metabolic-related diseases, among which diabetes, are prominent public health challenges of the 21st century. It is now well acknowledged that pollutants are a part of the equation, especially endocrine-disrupting chemicals (EDCs) that interfere with the hormonal aspect. The aim of the review is to focus on adipose tissue, a central regulator of energy balance and metabolic homeostasis, and to highlight the significant differences in the endocrine and metabolic aspects of adipose tissue between males and females which likely underlie the differences of the response to exposure to EDCs between the sexes. Moreover, the study also presents an overview of several mechanisms of action by which pollutants could cause adipose tissue dysfunction. Indeed, a better understanding of the mechanism by which environmental chemicals target adipose tissue and cause metabolic disturbances, and how these mechanisms interact and sex specificities are essential for developing mitigating and sex-specific strategies against metabolic diseases of chemical origin. In particular, considering that a scenario without pollutant exposure is not a realistic option in our current societies, attenuating the deleterious effects of exposure to pollutants by acting on the gut-adipose tissue axis may constitute a new direction of research.