Next Generation Sequencing (NGS) metrics following DOP-PCR whole genome amplification (WGA) of single and multi-cell samples for PGS

2016 ◽  
Author(s):  
Melinda Jasper
Keyword(s):  
Next Generation Sequencing ◽  
Whole Genome Amplification ◽  
Whole Genome ◽  
Next Generation ◽  
Genome Amplification ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

scholarly journals Comparative study of whole genome amplification and next generation sequencing performance of single cancer cells

Oncotarget ◽  
2016 ◽  
Vol 8 (34) ◽  
pp. 56066-56080 ◽  
Author(s):  
Anna Babayan ◽  
Malik Alawi ◽  
Michael Gormley ◽  
Volkmar Müller ◽  
Harriet Wikman ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Comparative Study ◽  
Cancer Cells ◽  
Whole Genome Amplification ◽  
Whole Genome ◽  
Next Generation ◽  
Genome Amplification ◽  
Single Cancer ◽  
Generation Sequencing

scholarly journals Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018

2019 ◽  
Vol 24 (2) ◽  
Author(s):  
Anja Berger ◽  
Alexandra Dangel ◽  
Tilmann Schober ◽  
Birgit Schmidbauer ◽  
Regina Konrad ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Corynebacterium Diphtheriae ◽  
Whole Genome ◽  
Next Generation ◽  
Insect Bites ◽  
Next Generation Sequencing Ngs ◽  
Ngs Data ◽  
Generation Sequencing

In September 2018, a child who had returned from Somalia to Germany presented with cutaneous diphtheria by toxigenic Corynebacterium diphtheriae biovar mitis. The child’s sibling had superinfected insect bites harbouring also toxigenic C. diphtheriae. Next generation sequencing (NGS) revealed the same strain in both patients suggesting very recent human-to-human transmission. Epidemiological and NGS data suggest that the two cutaneous diphtheria cases constitute the first outbreak by toxigenic C. diphtheriae in Germany since the 1980s.

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