Neurokinin B receptor antagonism suppresses ovarian follicle growth and delays ovulation in healthy women

2016 ◽  
Author(s):  
Richard Anderson
Keyword(s):  
Ovarian Follicle ◽  
Follicle Growth ◽  
Neurokinin B ◽  
Receptor Antagonism ◽  
Healthy Women

scholarly journals Neurokinin B Regulates Gonadotropin Secretion, Ovarian Follicle Growth, and the Timing of Ovulation in Healthy Women

2017 ◽  
Vol 103 (1) ◽  
pp. 95-104 ◽  
Author(s):  
Karolina Skorupskaite ◽  
Jyothis T George ◽  
Johannes D Veldhuis ◽  
Richard A Anderson
Keyword(s):  
Ovarian Follicle ◽  
Follicle Development ◽  
Follicle Growth ◽  
Duration Of Treatment ◽  
Neurokinin B ◽  
Gonadotropin Secretion ◽  
Lh Surge ◽  
Healthy Women ◽  
Follicle Diameter ◽  
Lh Secretion

Abstract Context Neurokinin B (NKB) is obligate for human puberty, but its role in adult female gonadotropin secretion and ovarian follicle growth is unknown. Objective To investigate antagonism of NKB on pulsatile gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion and ovarian follicle development in healthy women. Design Open investigation of the effects of a neurokinin-3 receptor (NK3R) antagonist (NK3Ra) vs a no-treatment control cycle. Setting Clinical research facility. Patients or other participants Healthy women with regular menses (n = 13). Intervention(s) NK3Ra MLE4901 40 mg taken orally twice daily from cycle day 5 to 6 for 7 days. Main outcome measure(s) LH secretion, ovarian follicle growth, and timing of ovulation. Results NK3Ra administration reduced basal LH secretion without a change in pulse frequency and delayed the LH surge by 7 days, the duration of treatment [mean cycle day ± standard error of the mean (SEM), 22 ± 1 days vs 15 ± 1 days in control cycles; P = 0.0006]. Follicle growth (mean diameter at the end of administration of NK3Ra administration ± SEM, 9.3 ± 0.4 mm vs 15.1 ± 0.9 mm in control cycles; P < 0.0001) and rising estradiol concentrations (mean ± SEM, 166 ± 29 pmol/L vs 446 ± 86 pmol/L in control cycles; P < 0.0001) were prevented. After treatment, follicle development resumed and normal preovulatory follicle diameter and estradiol concentrations were demonstrated. Postovulatory progesterone rise was similarly delayed (peak cycle day, 30 ± 2 vs 22 ± 1; P = 0.002) and cycle length was prolonged (35 ± 1 days vs 29 ± 1 days in control cycles; P = 0.0003) but luteal progesterone excretion was unaffected by the NK3Ra (LH surge day +7 mean urinary progesterone levels ± SEM, 58 ± 10 pmol/mol vs 48±7 pmol/mol creatinine in control cycles; nonsignificant). Conclusion These data demonstrate the involvement of NKB-NK3R signaling in the physiological regulation of GnRH/LH secretion, determining normal follicle development in women.

scholarly journals Mathematical modelling of oxygen transport-limited follicle growth

Reproduction ◽  
2007 ◽  
Vol 133 (6) ◽  
pp. 1095-1106 ◽  
Author(s):  
G P Redding ◽  
J E Bronlund ◽  
A L Hart
Keyword(s):  
Mathematical Modelling ◽  
Oxygen Transport ◽  
Size Range ◽  
Ovarian Follicle ◽  
Antral Follicle ◽  
Follicle Growth ◽  
Preantral Follicles ◽  
Formation Stage ◽  
Ultimate Fate ◽  
Further Development

Mathematical modelling was used to investigate oxygen transport in the developing ovarian follicle. In contrast to previous findings, the results show that oxygen can reach the oocyte in large preantral follicles. This is largely due to the inclusion of fluid voidage in the model and improved estimates of oxygen diffusion coefficients through the granulosa. The results also demonstrate that preantral follicles will eventually reach a size beyond which further growth will result in the follicle becoming increasingly anoxic. The predicted size range at which this occurs is consistent with the size range at which antrum formation is observed in many mammals. This suggests that the antrum formation stage of follicular growth may be pivotal to the further development and ultimate fate of the follicle, and that antrum formation itself may represent a mechanism by which the follicle can overcome oxygen limitations. This was supported through extension of the model to the antral follicle, which showed that antrum formation can provide a way in which the follicle can continue to grow and yet avoid becoming hypoxic. The results of the model were consistent with observed follicle development.

scholarly journals Involvement of hyaluronan synthesis in ovarian follicle growth in rats

Reproduction ◽  
2014 ◽  
Vol 147 (2) ◽  
pp. 189-197 ◽  
Author(s):  
Noriyuki Takahashi ◽  
Wataru Tarumi ◽  
Bunpei Ishizuka
Keyword(s):  
Ovarian Follicle ◽  
Primary Site ◽  
Corpora Lutea ◽  
Follicular Atresia ◽  
Follicle Growth ◽  
Adult Rats ◽  
Antral Follicles ◽  
Cell Layers ◽  
Ha Synthase

Most of the previous studies on ovarian hyaluronan (HA) have focused on mature antral follicles or corpora lutea, but scarcely on small preantral follicles. Moreover, the origin of follicular HA is unknown. To clarify the localization of HA and its synthases in small growing follicles, involvement of HA in follicle growth, and gonadotropin regulation of HA synthase (Has) gene expression, in this study, perinatal, immature, and adult ovaries of Wistar-Imamichi rats were examined histologically and biochemically and byin vitrofollicle culture. HA was detected in the extracellular matrix of granulosa and theca cell layers of primary follicles and more advanced follicles. Ovarian HA accumulation ontogenetically started in the sex cords of perinatal rats, and its primary site shifted to the intrafollicular region of primary follicles within 5 days of birth. TheHas1–3mRNAs were expressed in the ovaries of perinatal, prepubertal, and adult rats, and the expression levels ofHas1andHas2genes were modulated during the estrous cycle in adult rats and following administration of exogenous gonadotropins in immature acyclic rats. TheHas1andHas2mRNAs were predominantly localized in the theca and granulosa cell layers of growing follicles respectively. Treatments with chemicals known to reduce ovarian HA synthesis induced follicular atresia. More directly, the addition ofStreptomyceshyaluronidase, which specifically degrades HA, induced the arrest of follicle growth in anin vitroculture system. These results indicate that gonadotropin-regulated HA synthesis is involved in normal follicle growth.

Inhibition of Ovarian Follicle Growth by a Chemical Antiestrogen

1982 ◽  
Vol 16 (4) ◽  
pp. 230-236 ◽  
Author(s):  
R. Nakano ◽  
T. Nakayama ◽  
M. Iwao
Keyword(s):  
Ovarian Follicle ◽  
Follicle Growth

X-Ray Binary Stars and Ovarian Follicle Growth: Math Models in Astrophysics and Physiology

2010 ◽  
Author(s):  
Gordon E. Sarty ◽  
Curtis Saxton ◽  
Kinwah Wu ◽  
Roger Pierson ◽  
N. Mebarki ◽  
...  
Keyword(s):  
Binary Stars ◽  
Ovarian Follicle ◽  
Follicle Growth ◽  
X Ray

scholarly journals Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation

2019 ◽  
Author(s):  
Fabiana Cerqueira Campos ◽  
Cynthia Dennis ◽  
Hervé Alégot ◽  
Cornelia Fritsch ◽  
Adam Isabella ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Ovarian Follicle ◽  
Follicle Cell ◽  
Autonomous Control ◽  
Stress Fibers ◽  
Follicle Growth ◽  
Growth Promoting ◽  
Fibers Orientation ◽  
Open Question ◽  
The Relationship

SummaryHow extracellular matrix participates to tissue morphogenesis is still an open question. In the Drosophila ovarian follicle, it has been proposed that after Fat2-dependent planar polarization of the follicle cell basal domain, oriented basement membrane (BM) fibrils and F-actin stress fibers constrain follicle growth, promoting its axial elongation. However, the relationship between BM fibrils and stress fibers and their respective impact on elongation are unclear. We found that Dystroglycan (Dg) and Dystrophin (Dys) are involved in BM fibril deposition. Moreover, they orient stress fibers, by acting locally and in parallel to Fat2. Nonetheless, Dg-Dys complex-mediated cell autonomous control of F-actin fibers orientation relies on the previous BM fibril deposition, indicating two distinct but interdependent functions. Thus, the Dg-Dys complex works as a critical organizer of the epithelial basal domain, regulating both F-actin and BM. Furthermore, BM fibrils act as a persistent cue for the orientation of stress fibers that are the main effector of elongation.

Interpolation of Missing Part of Human Follicle Border on Ultrasonic B-Mode Image by Iterative Revision

2000 ◽  
Vol 22 (2) ◽  
pp. 108-122
Author(s):  
Y. Yamakoshi ◽  
M. Takemoto ◽  
N. Shinozuka
Keyword(s):  
Ovarian Follicle ◽  
A Priori ◽  
Three Dimensional ◽  
Closed Curve ◽  
Smoothness Condition ◽  
A Priori Information ◽  
Follicle Growth ◽  
Cross Sectional ◽  
Geometrical Characteristics ◽  
Priori Information

In clinical infertility treatments, assessment of ovarian follicle growth by ultrasonography is important. In order to measure the geometrical characteristics of the human follicle, such as the area of the cross-sectional image and the volume inside the follicle, a method based on manual tracing of the follicle contour from the ultrasonic B mode image is widely used. However, the observable ultrasonic B mode images are sometimes imperfect and some parts of the follicle border are missing due to the existence of the acoustic shadow. In this paper, a method that interpolates the missing part of the follicle border from the known part is proposed. This method uses a priori information of the follicle, which is usually known in actual cases: (1) the follicle's surface is so smooth that its border is assumed to be a smooth closed curve; and (2) the position of the follicle's center is roughly predicted in advance in the ultrasonic B-mode image. In the proposed method, the missing part of the human follicle border is interpolated from the known part by applying an iterative revision so as to satisfy the smoothness condition of the follicle. This method is also applied to three-dimensional image reconstruction of the human follicle.

Exposure to Bisphenol A Inhibits Ovarian Follicle Growth and Hormone Production in the Mouse.

2009 ◽  
Vol 81 (Suppl_1) ◽  
pp. 639-639
Author(s):  
Jackye Peretz ◽  
Tessie Paulose ◽  
Maria Isabel Hernandez Ochoa ◽  
Jodi Anne Flaws
Keyword(s):  
Bisphenol A ◽  
Ovarian Follicle ◽  
Follicle Growth ◽  
Hormone Production

scholarly journals P-083. Three-dimensional and flat environmental culture conditions for ovarian follicle growth and differentiation

1997 ◽  
Vol 12 (Suppl_2) ◽  
pp. 160-160 ◽  
Author(s):  
J.E. Gomes ◽  
S.C. Correia ◽  
A.J. Cidadão ◽  
C.E. Plancha
Keyword(s):  
Ovarian Follicle ◽  
Three Dimensional ◽  
Culture Conditions ◽  
Follicle Growth
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