DEVELOPMENT OF A NOVEL BIOIMAGING ALGORITHM FOR DIRECT ASSESSMENT OF CHEMO-RESPONSE IN ADVANCED OVARIAN CANCER PATIENTS

Author(s):  
Alexandros Laios
2021 ◽  
Vol 36 ◽  
pp. 100731
Author(s):  
Clarissa Polen-De ◽  
Carrie Langstraat ◽  
Gladys B. Asiedu ◽  
Aminah Jatoi ◽  
Amanika Kumar

Author(s):  
Antonio Gil-Moreno ◽  
Lorena Alonso-Alconada ◽  
Berta Díaz-Feijoo ◽  
Santiago Domingo ◽  
Ana Vilar ◽  
...  

2012 ◽  
Vol 38 (12) ◽  
pp. 1204-1210 ◽  
Author(s):  
F. Fanfani ◽  
A. Fagotti ◽  
M.G. Salerno ◽  
P.A. Margariti ◽  
M.L. Gagliardi ◽  
...  

2016 ◽  
Vol 15 ◽  
pp. CIN.S40660 ◽  
Author(s):  
Alexandros Laios ◽  
Davide Volpi ◽  
Rajeev Kumar ◽  
Zoe Traill ◽  
Borivoj Vojnovic ◽  
...  

In patients with advanced ovarian cancer (AOC), additional imaging of disseminated disease at laparoscopy could complement conventional imaging for estimation of chemotherapy response. We developed an image segmentation method and evaluated its use in making accurate and objective measurements of peritoneal metastases in comparison to Response Evaluation Criteria In Solid Tumors (RECIST) criteria. A software tool using a custom ImageJ macro-based approach was employed to estimate lesion size by converting image pixels into unit length. The software tool was tested as a proof-of-principle in an AOC patient with two isolated peritoneal deposits. Image analysis of representative laparoscopic snapshots before and after three cycles of neoadjuvant chemotherapy (NACT) revealed an average tumor nodule response ratio (TNRR) of 40% (partial response), which was in concordance with RECIST evaluation by computed tomography (CT). We demonstrated the feasibility of using this novel anatomical analysis for direct assessment of chemotherapy response in an AOC patient as an adjunct to RECIST criteria.


Aging ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 1066-1074 ◽  
Author(s):  
Claire Falandry ◽  
Béatrice Horard ◽  
Amandine Bruyas ◽  
Eric Legouffe ◽  
Jacques Cretin ◽  
...  

2015 ◽  
Vol 137 ◽  
pp. 53
Author(s):  
A. Kumar ◽  
M. Moynagh ◽  
B.A. Cliby ◽  
M. McGree ◽  
P. Young ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document