VITAMIN D DEFICIENCY AS RISK FACTOR FOR SEVERITY OF ACUTE LOWER RESPIRATORY TRACT INFECTIONS.

Author(s):  
Corina Cazan
2016 ◽  
Vol 47 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Kana Ram Jat

Studies related to vitamin D deficiency and lower respiratory tract infections (LRTI) in children have inconsistent findings. The objective of this systematic review was to assess the prevalence of vitamin D deficiency in children with LRTI, and to evaluate the correlation between vitamin D levels and the incidence and severity of LRTI. A total of 12 studies enrolling 2279 participants were included in our analysis. Children with LRTI were found to have significantly lower mean vitamin D levels as compared to controls There was likewise a correlation between vitamin D levels and incidence and severity of LRTI. Large randomised controlled trials are needed to evaluate effect of vitamin D supplementation for LRTI.


2020 ◽  
Author(s):  
Sinan Tüfekci ◽  
Erhan Aygün

Abstract Background: Newborn infants are exposed to life-threatening conditions such as severe lower respiratory tract infections mostly caused by a respiratory syncytial virus. Previous studies suggest vitamin D deficiency is associated with an increased risk of lower respiratory tract infections but this hypothesis is controversial. This study aimed to assess the relationship between serum vitamin D levels and the occurrence of lower respiratory tract infections among Turkish infants.Methods: We performed a case-control study including newborns admitted in the neonatal intensive care unit. Respiratory syncytial virus related respiratory infections were confirmed by the Respi-strip test. Clinical and biological data were collected from medical records and analyzed with Epi Info7.Results: We included 18 newborns (9 cases with the diagnosis of respiratory syncytial virus-related lower respiratory tract infections and 9 controls admitted with another diagnosis). Their mean age was 23.72 days and sex-ratio was 2. The main clinical symptoms of lower respiratory tract infections were cough, tachypnea, and fever and respiratory syncytial virus test was positive in all cases. Vitamin D level was significantly lower in cases compared to the control group (5.40 vs 17.67 ng/ml respectively). All newborns with lower respiratory tract infections presented vitamin D deficiency and 11.1 % of controls had normal vitamin D status. All babies and mothers with vitamin D deficiency were supplemented. Conclusion: Our results suggest that severe lower respiratory tract infections is associated with lower vitamin D levels among newborns admitted in neonatal intensive care unit. Vitamin D supplementation could help correct this deficiency and prevent postnatal severe lower respiratory tract infections.


2018 ◽  
Vol 1 (1) ◽  
pp. 5-8
Author(s):  
Henish Shakya ◽  
Saurav Singh ◽  
Ashish Lakhey

Introduction: Lower respiratory tract infection is a major cause of death in children in a developing country and anemia is found to be one of the commonest associated cofactors. This study was aimed to determine association of anemia in children with lower respiratory tract infections.Materials and Methods: The retrospective study was done over a one-year period for children under 5 years of age, admitted in Pediatric Ward of a tertiary Hospital in Lalitpur. The study included 100 diagnosed cases of lower respiratory tract infections as per WHO criteria and 100 age and sex matched patients who did not have respiratory complaints as controls, excluding prematurity, chronic diseases, malnutrition and severe systemic illness. Appropriate clinical history, examination routine investigations like hemoglobin, peripheral smear, and Chest X-ray were included.Results: The age distribution maximum children were in the age group of 3 months to 23 months with significant association with prevalence of both pneumonia (p value 0.005) and anemia (p value 0.002). Anemia was found to be a significant risk factor for LRTI (p value < 0.001) with odds ratio of 2.68 and 95% CI (1.51 – 4.75).Conclusions: Anemia was significantly found to be associated with lower respiratory tract infections and these children were found to be 2.68 times more susceptible to lower respiratory tract infections. Early diagnosis and prevention of anemia is thus important to reduce the incidence of lower respiratory tract infections in children.Nepalese Medical Journal. vol.1, No. 1, 2018, page: 5-8


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