IL-17a Knockout Attenuates Inflammatory Response and Mitochondrial Dysfunction after Hepatic Ischemia-reperfusion Injury

2017 ◽  
Author(s):  
Xin Xiang Yang
Keyword(s):  
Inflammatory Response ◽  
Mitochondrial Dysfunction ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats

2006 ◽  
Vol 26 (6) ◽  
pp. 734-741 ◽  
Author(s):  
Matthias Behrends ◽  
Ryutaro Hirose ◽  
Natalie J. Serkova ◽  
John L. Coatney ◽  
Melanie Bedolli ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Mild Hypothermia ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

scholarly journals Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Kristina L. Go ◽  
Sooyeon Lee ◽  
Ivan Zendejas ◽  
Kevin E. Behrns ◽  
Jae-Sung Kim
Keyword(s):  
Mitochondrial Dysfunction ◽  
Reperfusion Injury ◽  
Cell Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Major Complication ◽  
Therapeutic Approaches ◽  
Hepatic Ischemia ◽  
Mitochondrial Homeostasis ◽  
Hepatic Ischemia Reperfusion

Ischemia/reperfusion (I/R) injury remains a major complication of liver resection, transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic I/R are complex and diverse involving the interaction of cell injury in hepatocytes, immune cells, and endothelium, mitochondrial dysfunction is a cardinal event culminating in hepatic reperfusion injury. Mitochondrial autophagy, so-called mitophagy, is a key cellular process that regulates mitochondrial homeostasis and eliminates damaged mitochondria in a timely manner. Growing evidence accumulates that I/R injury is attributed to defective mitophagy. This review aims to summarize the current understanding of autophagy and its role in hepatic I/R injury and highlight the various therapeutic approaches that have been studied to ameliorate injury.

scholarly journals Repressor and activator protein accelerates hepatic ischemia reperfusion injury by promoting neutrophil inflammatory response

Oncotarget ◽  
2016 ◽  
Vol 7 (19) ◽  
pp. 27711-27723 ◽  
Author(s):  
Chang Xian Li ◽  
Chung Mau Lo ◽  
Qizhou Lian ◽  
Kevin Tak-Pan Ng ◽  
Xiao Bing Liu ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Activator Protein ◽  
Hepatic Ischemia Reperfusion
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