REAL-WORLD HEALTHCARE UTILISATION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE NEWLY TREATED WITH VEDOLIZUMAB AND ANTI-TUMOUR NECROSIS FACTOR AGENTS

2017 ◽  
Author(s):  
Mark Osterman
Keyword(s):  
Inflammatory Bowel Disease ◽  
Tumour Necrosis Factor ◽  
Real World ◽  
Bowel Disease ◽  
Tumour Necrosis ◽  
Healthcare Utilisation ◽  
Inflammatory Bowel ◽  
Necrosis Factor

scholarly journals Anti-tumour necrosis factor treatment of inflammatory bowel disease in liver transplant recipients

2012 ◽  
Vol 36 (6) ◽  
pp. 569-574 ◽  
Author(s):  
A. B. Mohabbat ◽  
W. J. Sandborn ◽  
E. V. Loftus ◽  
R. H. Wiesner ◽  
D. H. Bruining
Keyword(s):  
Inflammatory Bowel Disease ◽  
Liver Transplant ◽  
Tumour Necrosis Factor ◽  
Bowel Disease ◽  
Tumour Necrosis ◽  
Transplant Recipients ◽  
Inflammatory Bowel ◽  
Liver Transplant Recipients ◽  
Necrosis Factor

Review article: chronic viral infection in the anti-tumour necrosis factor therapy era in inflammatory bowel disease

2010 ◽  
Vol 31 (1) ◽  
pp. 20-34 ◽  
Author(s):  
M. J. SHALE ◽  
C. H. SEOW ◽  
C. S. COFFIN ◽  
G. G. KAPLAN ◽  
R. PANACCIONE ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Viral Infection ◽  
Tumour Necrosis Factor ◽  
Bowel Disease ◽  
Tumour Necrosis ◽  
Review Article ◽  
Chronic Viral Infection ◽  
Factor Therapy ◽  
Inflammatory Bowel ◽  
Necrosis Factor

Circulating Tumour Necrosis Factor in Active Inflammatory Bowel Disease

1993 ◽  
pp. 699-703 ◽  
Author(s):  
K. R. Gardiner ◽  
M. I. Halliday ◽  
F. Lloyd ◽  
S. Stephens ◽  
B. J. Rowlands
Keyword(s):  
Inflammatory Bowel Disease ◽  
Tumour Necrosis Factor ◽  
Bowel Disease ◽  
Tumour Necrosis ◽  
Active Inflammatory Bowel Disease ◽  
Inflammatory Bowel ◽  
Necrosis Factor

scholarly journals P574 Incidence and indicators of suboptimal response to tumour necrosis factor antagonist therapy in Chinese patients with inflammatory bowel disease: Results from the EXPLORE study

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S483-S484
Author(s):  
J Li ◽  
Z Li ◽  
P Hu ◽  
Z Wen ◽  
Q Cao ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Tumour Necrosis Factor ◽  
Bowel Disease ◽  
Tumour Necrosis ◽  
Retrospective Chart Review ◽  
Chinese Patients ◽  
First Line ◽  
Related Hospitalisation ◽  
Inflammatory Bowel ◽  
Necrosis Factor

Abstract Background Inflammatory bowel disease (IBD) patients may experience a suboptimal response to anti-tumour necrosis factor (TNF) therapy. In China, these data are limited. The EXPLORE study aimed to assess the incidence and indicators of suboptimal response to first-line anti-TNF agents in IBD patients in real-world practice in the newly industrialised countries. Methods The EXPLORE study was a multinational, retrospective chart review study. In the China subgroup, adult patients from 10 centres diagnosed with ulcerative colitis (UC) or Crohn’s disease (CD) and who initiated first anti-TNF treatment between March 2010 and March 2015, were included. The cumulative incidence (CI) of suboptimal response was assessed over 24 months since the anti-TNF initiation. The indicators of suboptimal response included: IBD-related hospitalisation, dose-escalation, discontinuation including switch to another anti-TNF, non-biologic therapy augmentation, or IBD-related surgery. Primary non-response (PNR) and secondary loss of response (SLOR) were defined as any suboptimal response indicator at <4 and ≥4 months after anti-TNF initiation, respectively. Results Overall, 287 first-line anti-TNF treated patients (35 UC; 252 CD) were included: male, UC 54.3% (n = 19), CD 74.6% (n = 188); mean (SD) age (years), UC 43.1 (14.2), CD 31.9 (11.3); median (min-max) disease duration (years), UC 1.0 (0–9), CD <1 year (0–21); median (min-max) follow-up (months), UC 27.6 (24–60), CD 40.0 (24–60). At 12 and 24 months, the CI of suboptimal response to first anti-TNF treatment was 51.4% and 75.7% in UC, 45.4% and 57.0% in CD, respectively (Figure 1). The median time to the first suboptimal response was 7.2 months in UC and 14.3 months in CD. The CI of PNR was 31.2% in UC and 33.7% in CD. The CI of SLOR was 29.4% and 64.7% in UC, 17.7% and 35.2% in CD at 12 and 24 months, respectively. The most frequent first suboptimal response indicator was ‘discontinuation of anti-TNF therapy’ in UC patients (56.3%) while for CD patients it was ‘IBD-related hospitalisation’ (56.1%) followed by ‘augmentation with non-biological therapy’ in both cohorts (UC 31.3%; CD 22.8%). Conclusion Approximately three-quarters of UC and over half of CD patients experienced a suboptimal response to their first anti-TNF agent at 24 months. Given the high unmet needs observed with anti-TNF therapies in China, IBD patients may benefit from greater optimisation of care and new biologic options.

scholarly journals Tuberculosis in Anti-Tumour Necrosis Factor-treated Inflammatory Bowel Disease Patients After the Implementation of Preventive Measures: Compliance With Recommendations and Safety of Retreatment

2016 ◽  
Vol 10 (10) ◽  
pp. 1186-1193 ◽  
Author(s):  
D. Carpio ◽  
A. Jauregui-Amezaga ◽  
R. de Francisco ◽  
L. de Castro ◽  
M. Barreiro-de Acosta ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Tumour Necrosis Factor ◽  
Bowel Disease ◽  
Tumour Necrosis ◽  
Preventive Measures ◽  
Inflammatory Bowel ◽  
Necrosis Factor
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