INTERLEUKIN-6 (IL-6) IS A POTENTIAL BIOMARKER OF PLAQUE-DERIVED SYSTEMIC INFLAMMATION IN PATIENTS WITH TRANSIENT ISCHAEMIC ATTACK AND CAROTID STENOSIS.

2018 ◽  
Author(s):  
Sarah Coveney
Keyword(s):  
Carotid Stenosis ◽  
Systemic Inflammation ◽  
Interleukin 6 ◽  
Transient Ischaemic Attack ◽  
Potential Biomarker ◽  
Ischaemic Attack

scholarly journals Relationship between Lipoprotein (a) and Both Stroke and Carotid Atheroma

1997 ◽  
Vol 34 (4) ◽  
pp. 360-365 ◽  
Author(s):  
Hugh S Markus ◽  
Rupal Kapadia ◽  
Roy A Sherwood
Keyword(s):  
Carotid Stenosis ◽  
Patient Group ◽  
Transient Ischaemic Attack ◽  
Case Control Studies ◽  
Stroke Subtype ◽  
Lipoprotein A ◽  
Unselected Population ◽  
Ischaemic Attack ◽  
The Relationship

In vitro studies provide mechanisms by which elevated lipoprotein(a) [Lp(a)] concentrations may promote both thrombosis and atherogenesis. Case-control studies have reported raised Lp(a) concentrations in patients with stroke, but prospective studies have failed to confirm the association. A potential confounding factor is that Lp(a) may rise acutely after stroke. We determined Lp(a) concentrations in 164 patients studied at least 21 days after stroke or transient ischaemic attack, and in 91 controls. In the patient group we correlated Lp(a) concentrations with both the degree of carotid stenosis estimated on duplex ultrasonography, and with stroke subtype (large vessel disease, lacunar infarction, and cardioembolic and unknown pathogenesis). There was no difference between Lp(a) concentration in cases and controls [median (quartiles) 0·10 (0·04, 0·39) versus 0·12 (0·04, 0·30) g/L, P = 0·34]. There was no difference in the proportion of cases compared with controls with a markedly elevated Lp(a) of > 0·4g/L (21·3 versus 16·5%, P = 0·34). There was non-significant trend towards higher median Lp(a) concentrations in women [median (quartiles) 0·16 (0·04, 0·32)g/L versus 0·12 (0·04, 0·28) g/L, P = 0·3]. In view of this trend we analysed the differences between cases and controls for each sex separately. Lp(a) concentrations in men were median (quartiles) 0·08 (0·04, 0·26)g/L in the 101 cases and 0·12 (0·04, 0·28) g/L in the 43 controls ( P = 0·6). Lp(a) concentrations in women were median (quartiles) 0·25 (0·04, 0·44) g/L in the 63 cases, and 0·16 (0·04, 0·32) g/L in the 48 controls ( P = 0·16). Within the patient group there was no difference between Lp(a) concentrations in the different stroke subgroups. There was no relationship between Lp(a) concentrations and mean percentage carotid stenosis ( rs = 0·14, P = 0·07). Our results suggest that in an unselected population of men studied more than 3 weeks post event there is no relationship between lipoprotein(a) concentrations and either stroke/transient ischaemic attack, or carotid atheroma. The relationship in women requires further study.

Age but not ABCD2score predicts any level of carotid stenosis in either symptomatic or asymptomatic side in transient ischaemic attack

2015 ◽  
Vol 69 (9) ◽  
pp. 948-956 ◽  
Author(s):  
G. S. Mannu ◽  
M. M. Kyu ◽  
J. H. Bettencourt-Silva ◽  
Y. K. Loke ◽  
A. B. Clark ◽  
...  
Keyword(s):  
Carotid Stenosis ◽  
Transient Ischaemic Attack ◽  
Ischaemic Attack

scholarly journals Carotid artery stenosis, an underestimated cause of stroke recurrence in patients with ischaemic monocular visual loss

2019 ◽  
Vol 101 (8) ◽  
pp. 579-583
Author(s):  
SF Cheng ◽  
A Zarkali ◽  
T Richards ◽  
R Simister ◽  
A Chandratheva
Keyword(s):  
Carotid Stenosis ◽  
Transient Ischaemic Attack ◽  
Visual Loss ◽  
Surgical Intervention ◽  
Recurrent Stroke ◽  
Stroke Recurrence ◽  
Symptomatic Carotid ◽  
Symptomatic Carotid Stenosis ◽  
Ischaemic Attack ◽  
Transient Visual Loss

Introduction Isolated monocular ischaemic events are thought to be low risk for stroke recurrence. In the presence of carotid stenosis however, the risks should not be treated similarly and surgical intervention should be considered at an early stage. The aim of this study was to determine the vascular risk profile and stroke recurrence in patients with ischaemic monocular visual loss. Methods and methods Consecutive records for all patients with monocular ischaemia were reviewed from January 2014 to October 2016. Stroke, transient ischaemic attack or monocular ischaemia recurrence within 90 days were recorded. Carotid stenosis was assessed with duplex ultrasound, computed tomography or magnetic resonance angiography. Results In total, 400 patients presented with monocular ischaemia; 391 had carotid imaging (97.8%). Causality was symptomatic carotid stenosis ≥ 50% in 53 (13.6%), including carotid stenosis ≥ 70% in 31 (7.9%). Patients with permanent visual loss (n = 131) were more likely to have significant stenosis compared with patients with transient visual loss (n = 260), 19.8% compared with 10.4% (P = 0.012). Recurrent stroke, transient ischaemic attack or monocular ischaemia within 90 days after presentation occurred in three patients (5.7%) in the carotid stenosis group, compared to three (0.9%) who did not have stenosis (P = 0.035). Age, male sex and hypertension were associated with carotid stenosis but hypercholesterolaemia, diabetes and smoking were not. Conclusions Carotid stenosis ≥ 50% is present in patients with ocular ischaemia in approximately 20% of those with persistent visual loss and in 10% with transient visual loss. Those with carotid stenosis have a higher risk of stroke recurrence and should be considered urgent surgical intervention as other forms of stroke.

Interleukin-6 as an Early Predictor for One-Year Survival following an Ischaemic Stroke/Transient Ischaemic Attack

2010 ◽  
Vol 5 (1) ◽  
pp. 16-20 ◽  
Author(s):  
S. Shenhar-Tsarfaty ◽  
E. Ben Assayag ◽  
I. Bova ◽  
L. Shopin ◽  
M. Fried ◽  
...  
Keyword(s):  
Ischaemic Stroke ◽  
Interleukin 6 ◽  
Transient Ischaemic Attack ◽  
Ischaemic Attack ◽  
One Year ◽  
Early Predictor
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