INTERLEUKIN-6 INDEPENDENTLY PREDICTS LATE FATALITY AND POOR FUNCTIONAL OUTCOME AFTER TRANSIENT ISCHAEMIC ATTACK (TIA) AND NON SEVERE STROKE

2018 ◽  
Author(s):  
Sarah Coveney
Keyword(s):  
Functional Outcome ◽  
Interleukin 6 ◽  
Transient Ischaemic Attack ◽  
Poor Functional Outcome ◽  
Severe Stroke ◽  
Ischaemic Attack

Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack

2019 ◽  
Vol 26 (8) ◽  
pp. 1082-1090
Author(s):  
A. Wang ◽  
X. Zhang ◽  
S. Li ◽  
X. Zhao ◽  
L. Liu ◽  
...  
Keyword(s):  
Functional Outcome ◽  
Transient Ischaemic Attack ◽  
Minor Stroke ◽  
Poor Functional Outcome ◽  
Ischaemic Attack

scholarly journals 192 Interleukin-6 and C-Reactive Protein Predict all Cause Death and Poor Functional Outcome after Non-Severe Stroke and Transient Ischaemic Attack

2019 ◽  
Vol 48 (Supplement_3) ◽  
pp. iii1-iii16
Author(s):  
Sarah Coveney ◽  
John J McCabe ◽  
Murphy Sean ◽  
Orina Belton ◽  
M Crowe ◽  
...  
Keyword(s):  
Functional Outcome ◽  
Trauma Surgery ◽  
C Reactive Protein ◽  
Poor Functional Outcome ◽  
Severe Stroke ◽  
Cox Regression Analysis ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Unit Increase

Abstract Background Inflammation plays a role in the development of ischaemic cerebrovascular events. High sensitivity C-reactive protein (CRP) is known to predict recurrent events. Little data exists for more upstream serum markers of inflammation. Methods BIO-STROKE and BIO-TIA were multicentre prospective biomarker and imaging studies of patients with non-severe stroke, TIA and controls. Exclusion criteria were malignancy, infection, recent trauma / surgery, recurrent stroke before phlebotomy/MRI. Serum biomarkers analysed included Interleukin (IL) – 6, CRP, IL-1, IL-8, IL10, IL12p70, IFN and TNF.Plasma CRP and IL-6 were measured by mass spectrometry. Additional biomarkers were measured using ELISA. Follow up was performed at 7, 28, 90 days and 1 year. Results 680 patients (439 strokes, 241 TIAs) and 68 controls were included in the analysis. The median age was 70 for cases. Carotid stenosis was present in 23.6% of cases. Median CRP was 3.75mg/L, 2.36mg/l and 1.87mg/L in the stroke, TIA and control groups (p=<0.001). Median IL-6 was 5.86pg/ml (stroke), 4.25pg/ml (TIA), 3.06pg/ml (control) (p=<0.001). On multivariate cox regression analysis baseline IL6 and CRP were independent predictors of all cause death at 1 year with a HR of 1.005 (95% CI 1.002-1.007, p<0.001).and 1.005(95% CI 1.002-1.007, p<0.001) per unit increase. Both IL6 and CRP were associated with vascular death at 1 year. In adjusted analyses, IL6 and CRP were associated with poor functional outcome at 1 year (OR of 1.02(CI 1.01 -1.03) and 1.02(CI 1.01-1.03) per unit increase, for IL6 and CRP respectively). On adjusted analysis, when IL6 was analysed as quartiles, there was a strong association with death at 1 year with an OR 1.87 (95% CI 1.19-2.93).CRP, analysed as quartiles, demonstrated an OR for death at 1 year of 1.64 (1.10-2.46). Conclusion IL-6 and CRP may be a useful prognostic factor for the prediction of outcome and death after stroke at 1 year follow up.

Severe Disability After Stroke: Outcome After Inpatient Rehabilitation

1999 ◽  
Vol 13 (3) ◽  
pp. 199-203 ◽  
Author(s):  
John G. Schmidt ◽  
Jessie Drew-Cates ◽  
Mary L. Dombovy
Keyword(s):  
Functional Outcome ◽  
Hemorrhagic Stroke ◽  
Inpatient Rehabilitation ◽  
Functional Independence ◽  
Efficiency Score ◽  
Poor Functional Outcome ◽  
Rehabilitation Unit ◽  
Home Setting ◽  
Severe Stroke ◽  
Acute Rehabilitation

Objective: To determine the functional outcome following acute rehabilitation of patients with severe and very severe stroke using the Functional Independence Mea sure (FIM). Background: Most patients with severe and very severe stroke are reported in the literature to have a poor functional outcome. However, there are few studies that specifically address severity and their conclusions are confounding. Methods: We retrospectively reviewed charts of 41 consecutive patients with the primary diag nosis of ischemic or hemorrhagic stroke admitted to an inpatient rehabilitation unit with a admission FIM score of <60. Outcome measures included discharge residence, length of stay, and FIM score. Results: Over 63 percent (26 patients) were discharged to home. Discharge mean FIM scores (61.24) were significantly improved over the admission mean FIM (34.12) for self-care, mobility, communication, and social cog nition. The FIM Efficiency score was 0.356/day (mean[FIMdis-FIMadm]/mean LOS) as compared with previous reports of FIM Efficiency of 0.97/day for all stroke. Con clusion: Patients with severe stroke can experience improvement during inpatient rehabilitation and be discharged to a home setting, although the rate of improvement is less than that of more moderate stroke.

scholarly journals Cognitive screening improves the predictive value of stroke severity scores for functional outcome 3–6 months after mild stroke and transient ischaemic attack: an observational study

BMJ Open ◽  
2013 ◽  
Vol 3 (9) ◽  
pp. e003105 ◽  
Author(s):  
YanHong Dong ◽  
Melissa Jane Slavin ◽  
Bernard Poon-Lap Chan ◽  
Narayanaswamy Venketasubramanian ◽  
Vijay Kumar Sharma ◽  
...  
Keyword(s):  
Observational Study ◽  
Functional Outcome ◽  
Transient Ischaemic Attack ◽  
Predictive Value ◽  
Stroke Severity ◽  
Cognitive Screening ◽  
Severity Scores ◽  
Ischaemic Attack ◽  
Mild Stroke

Interleukin-6 as an Early Predictor for One-Year Survival following an Ischaemic Stroke/Transient Ischaemic Attack

2010 ◽  
Vol 5 (1) ◽  
pp. 16-20 ◽  
Author(s):  
S. Shenhar-Tsarfaty ◽  
E. Ben Assayag ◽  
I. Bova ◽  
L. Shopin ◽  
M. Fried ◽  
...  
Keyword(s):  
Ischaemic Stroke ◽  
Interleukin 6 ◽  
Transient Ischaemic Attack ◽  
Ischaemic Attack ◽  
One Year ◽  
Early Predictor
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