Effects of prenatal exposure to methylazoxymethanol acetate on juvenile social play behavior and ultrasonic communication in male and female rats

2018 ◽  
Author(s):  
Jakub Mlost ◽  
Agnieszka Potasiewicz ◽  
Piotr Popik ◽  
Agnieszka Nikiforuk
Keyword(s):  
Prenatal Exposure ◽  
Social Play ◽  
Play Behavior ◽  
Female Rats ◽  
Male And Female ◽  
Methylazoxymethanol Acetate ◽  
Male And Female Rats ◽  
Social Play Behavior ◽  
Ultrasonic Communication

scholarly journals Social interaction with an alcohol-intoxicated or cocaine-injected peer selectively alters social behaviors and drinking in adolescent male and female rats

2019 ◽  
Author(s):  
Danielle M. Gamble ◽  
Chloe C. Josefson ◽  
Mary K. Hennessey ◽  
Ashley M. Davis ◽  
Renee C. Waters ◽  
...  
Keyword(s):  
Social Interaction ◽  
Alcohol Drinking ◽  
Social Play ◽  
Social Behaviors ◽  
Ethanol Intake ◽  
Female Rats ◽  
Adolescent Male ◽  
Saccharin Consumption ◽  
Male And Female ◽  
Male And Female Rats

AbstractBackgroundDrinking alcohol is facilitated by social interactions with peers, especially during adolescence. The importance of peer social influences during adolescence on alcohol and substance use have recently received more attention. We have shown that social interaction with an alcohol-intoxicated peer influences adolescent alcohol drinking differently in male and female rats using the demonstrator-observer paradigm. The present set of experiments analyzed the social interaction session to determine behaviors that influence alcohol drinking in adolescent male and female rats.MethodsSpecifically, in experiment one we determined which behaviors were altered during social interaction with an alcohol-intoxicated demonstrator and assessed changes in ethanol intake in adolescent observers. Experiment two examined changes in voluntary saccharin consumption to determine if social interaction with an alcohol-intoxicated demonstrator altered consumption of a palatable solution. In experiment three, we administered a low (5 mg/kg) or high (20 mg/kg) dose of cocaine to the demonstrator and assessed changes in the adolescent observers to determine if social interaction with a ‘drugged’ peer altered social behaviors and voluntary ethanol intake.ResultsWe showed that social interaction with an alcohol-intoxicated demonstrator (1) decreased social play and increased social investigation and social contact in adolescent male and female observers, (2) did not alter non-social behaviors, (3) did not alter saccharin consumption and (4) increased voluntary ethanol intake in adolescent female but not male observers. When the peer was injected with cocaine (1) social play was dose-dependently decreased, (2) there were no changes in other social or non-social behaviors, and (3) voluntary ethanol intake in adolescent male and female observers was unaffected.ConclusionsThe present results are consistent and extend our previous work showing that social interaction with an alcohol-intoxicated peer selectively alters social behaviors and alcohol-drinking in adolescent rats. Females appear to be more sensitive to elevating effects of social interaction on voluntary ethanol consumption.

Prenatal exposure to alcohol impairs social play behavior in adolescent male mice

2020 ◽  
Vol 79 ◽  
pp. 142-149
Author(s):  
Mara A.P. de Ávila ◽  
Rebeca M. Gonçalves ◽  
Elisandra C.C. Nascimento ◽  
Layla D.M. Cabral ◽  
Fabiana C. Vilela ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Social Play ◽  
Play Behavior ◽  
Adolescent Male ◽  
Male Mice ◽  
Social Play Behavior

Sex‐dependent effects of Cacna1c haploinsufficiency on juvenile social play behavior and pro‐social 50‐kHz ultrasonic communication in rats

2019 ◽  
Vol 19 (2) ◽  
Author(s):  
Theresa M. Kisko ◽  
Moria D. Braun ◽  
Susanne Michels ◽  
Stephanie H. Witt ◽  
Marcella Rietschel ◽  
...  
Keyword(s):  
Social Play ◽  
Play Behavior ◽  
Social Play Behavior ◽  
Ultrasonic Communication

scholarly journals Prenatal Exposure to Lamotrigine: Effects on Postnatal Development and Behaviour in Rat Offspring

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Sekar Sathiya ◽  
Murugan Ganesh ◽  
Periyathambi Kalaivani ◽  
Vijayan Ranju ◽  
Srinivasan Janani ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Prenatal Exposure ◽  
Clinical Signs ◽  
Female Offspring ◽  
Receptor Expression ◽  
Female Rats ◽  
Sprague Dawley ◽  
Pregnant Rats ◽  
Male And Female ◽  
Male And Female Rats

Use of antiepileptic drugs (AEDs) in pregnancy warrants various side effects and also deleterious effects on fetal development. The present study was carried out to assess the effects of prenatal exposure to lamotrigine (LTG) on postnatal development and behavioural alterations of offspring. Adult male and female Sprague Dawley rats weighing 150–180 g b. wt. were allowed to copulate and pregnancy was confirmed by vaginal cytology. Pregnant rats were treated with LTG (11.5, 23, and 46 mg/kg, p.o) from gestational day 3 (GND 3) and this treatment continued till postnatal day 11 (PND 11). Offspring were separated from their dam on day 21 following parturition. LTG, at 46 mg/kg, p.o, produced severe clinical signs of toxicity leading to death of dam between GND 15 and 17. LTG, at 11.5 and 23 mg/kg, p.o, showed significant alterations in offspring’s incisors eruption and vaginal opening when compared to age matched controls. LTG (23 mg/kg, p.o) exposed female offspring expressed hyperactive behaviour and decreased GABA-A receptor expression when compared to control rats. These results reveal that prenatal exposure to LTG may impart differential postnatal behavioural alterations between male and female rats which paves way for further investigations.

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