Overexpression of thymidine phosphorylase in Mycoplasma hominis as a factor in the formation of variants of small colonies

2020 ◽  
Author(s):  
Evsyutina Daria
Keyword(s):  
Thymidine Phosphorylase ◽  
Mycoplasma Hominis

MYCOPLASMA AND CHLAMYDIA AS ETHIOLOGICAL FACTORS OF BRONCHIAL ASTHMA IN TERMS OF ETHNOGENESIS

2013 ◽  
Vol 68 (7) ◽  
pp. 57-60
Author(s):  
O. A. Sharavii ◽  
S. V. Smirnova
Keyword(s):  
Immune Response ◽  
Chlamydia Trachomatis ◽  
Blood Serum ◽  
Bronchial Asthma ◽  
Mycoplasma Hominis ◽  
Acute Stage ◽  
Control Group ◽  
Clinical Markers ◽  
Chlamydophila Psittaci ◽  
Asthma Patients

 Aim. The study of the prevalence and clinical peculiarities of Mycoplasmosis and Chlamydiosis in patients with different pathogenic forms of bronchial asthma (BA) taking into account ethnicity of a patient. Subjects and Methods. The research covered 239 subjects – both the Europeoids and the Mongoloids in the city of Krasnoyarsk and the town of Kyzyl, all of them being BA patients of different stages, including acute stage and practically healthy. We had determined antigens Mycoplasma pneumoniae, Mycoplasma hominis, Chlamydophila pneumoniae, Chlamydophila psittaci and Chlamydia trachomatis in smears of mucosa of pharynx and antibodies to these antigens in peripheral blood serum. Results.  We found high frequency of Mycoplasmosis and Chlamydiosis in the inhabitants of Eastern Siberia, BA patients with different pathogenic forms as compared to control group. We had determined ethnic peculiarities of specific immune response: IgM to М. pneumoniae was revealed in the Europoids more frequently than in the Mongoloids, but IgM to С. pneumoniae and to C. trachomatis, C. trachomatis antigens had been revealed more often in the Mongoloids than in the Europoids. We accepted as clinical equivalents of Mycoplasmosis and Chlamydiosis diagnostics the following signs: temperature around 37C (subfebrile temperature), non-intensive but stable coughing with scanty mucous and muco-purulent sputum, dyspnea of mixed character. Conclusions. Mycoplasma and Chlamydia are meaningful etiologic factors of bronchial asthma. We have found the peculiarities of immune response depending on ethnicity of a patient (ethnic belonging). Clinical markers of Mycoplasmosis and Chlamydiosis should be taken into account in bronchial asthma in order to provide diagnostics timely as well as eradication of infection agents. Because of insufficient knowledge of problem of bronchial asthma related to contamination with Мycoplasma and Chlamydia we put the goal to study the frequency of Mycoplasmosis and Chlamydiosis occurrence in bronchial asthma patients and determine the characteristics clinical course of diseases. We defined antigens Мycoplasma pneumoniae, Мycoplasma hominis, Chlamydophila pneumoniaе, Chlamydophila psittaci, Chlamydia trachomatis in smears of oropharynx mucosa and antibodies to them in blood serum. 

Exemplar Abstract for Mycoplasma hominis (Freundt 1953) Edward 1955 (Approved Lists 1980).

2003 ◽  
Author(s):  
Charles Thomas Parker ◽  
Dorothea Taylor ◽  
George M Garrity
Keyword(s):  
Mycoplasma Hominis

Thymidine Phosphorylase Over-Expression in Oral Squamous Carcinoma Tissue as a Potential Target of Capecitabine

2004 ◽  
Vol 1 (1) ◽  
pp. 45-49 ◽  
Author(s):  
G. Ranieri ◽  
R. Patruno ◽  
G. Fiore ◽  
G. Saponaro ◽  
A. Paradiso ◽  
...  
Keyword(s):  
Thymidine Phosphorylase ◽  
Squamous Carcinoma ◽  
Over Expression ◽  
Carcinoma Tissue ◽  
Potential Target ◽  
Oral Squamous Carcinoma

The silent presence of Mycoplasma hominis in patients with prostate cancer

2020 ◽  
Vol 78 (7) ◽  
Author(s):  
Saman Saadat ◽  
Pezhman Karami ◽  
Mohammad Jafari ◽  
Mahdi Kholoujini ◽  
Zahra Rikhtegaran Tehrani ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mycoplasma Hominis ◽  
Opportunistic Pathogen ◽  
Host Cells ◽  
Prostate Tissue ◽  
Control Group ◽  
P Value ◽  
Retrospective Case ◽  
Formalin Fixed Paraffin Embedded ◽  
Pcr Targeting

ABSTRACT Background Mycoplasma hominis, an opportunistic pathogen in human genitourinary tract, can cause chronic infection in the prostate. Intracellular survival of M. hominis leads to a prolonged presence in the host cells that can affect the cell's biological cycle. In the present study, we aimed to evaluate the frequency of M. hominis DNA in prostate tissue of Iranian patients with prostate cancer (PCa) in comparison to a control group with benign prostatic hyperplasia (BPH). Methods This research was a retrospective case-control study using 61 archived formalin-fixed paraffin-embedded (FFPE) blocks of prostate tissue from patients with PCa and 70 FFPE blocks of patients with BPH. Real-time PCR, targeting two different genes, 16S rRNA and yidC, in the M. hominis genome was performed for all specimens. Results Out of 61 blocks of prostate biopsy from patients with PCa, eight samples (13%) were positive for M. hominis, while the bacterium was not detected in any of the 70 blocks of patients with BPH (P value, 0.002). Conclusions The high frequency of M. hominis in patients with PCa likely shows a hidden role of the organism in prostate cancer during its chronic, apparently silent and asymptomatic colonization in prostate.

scholarly journals The Generation of Energy by the Arginine Dihydrolase Pathway in Mycoplasma hominis 07

1966 ◽  
Vol 241 (10) ◽  
pp. 2228-2236
Author(s):  
Robert T. Schimke ◽  
C.M. Berlin ◽  
E.W. Sweeney ◽  
William R. Carroll
Keyword(s):  
Mycoplasma Hominis ◽  
Arginine Dihydrolase
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