Contrast-enhanced mammography-guided preoperative wire localization of breast lesions: A feasibility study of an adapted pre-operative localizing technique to improve tissue-sampling in challenging cases.

2021 ◽  
Author(s):  
Marcio Mitsugui Saito
Keyword(s):  
Feasibility Study ◽  
Breast Lesions ◽  
Tissue Sampling ◽  
Wire Localization ◽  
Contrast Enhanced

scholarly journals Added value of Contrast Enhanced Mammography (CEM) in staging of malignant breast lesions – a feasibility study

2020 ◽  
Author(s):  
Kristina Åhsberg ◽  
Anna Gardfjell ◽  
Emma Nimeus ◽  
Rogvi Rasmussen ◽  
Catharina Behmer ◽  
...  
Keyword(s):  
Adverse Events ◽  
Feasibility Study ◽  
Digital Mammography ◽  
Preoperative Staging ◽  
Added Value ◽  
Breast Lesions ◽  
Primary Surgery ◽  
Standard Assessment ◽  
Contrast Enhanced ◽  
Malignant Breast

Abstract Objectives: The aim of this feasibility study was to evaluate the added value of contrast enhanced mammography (CEM) in preoperative staging of malignant breast lesions, beyond standard assessment with digital mammography and ultrasound, as a base for a future prospective randomized trial. Materials and methods: Forty-seven patients, with confirmed or strongly suspected malignant breast lesions after standard assessment (digital mammography (DM) and ultrasound (US)), scheduled for primary surgery, were invited to undergo CEM as an additional preoperative procedure. The primary endpoint was change in treatment due to CEM findings, defined as mastectomy instead of partial mastectomy or contrariwise, bilateral surgery instead of unilateral or neoadjuvant treatment instead of primary surgery. Accuracy in tumour extent estimation compared to histopathology was evaluated by Bland Altman statistics. Number of extra biopsies and adverse events were recorded.Results: In 10/47 patients (21%), findings from CEM affected the primary treatment. Agreement with histopathology regarding extent estimation was better for CEM (mean difference -1.36, SD +/- 18.45) in comparison with DM (-4.18, SD +/- 26.20) and US (-8.36, SD +/- 24.30). Additional biopsies were taken from 19 lesions in 13 patients. Nine biopsies showed malignant outcome. No major adverse events occurred. Conclusion: The feasibility of preoperative additional CEM was found to be satisfactory without any serious negative effects. Results imply an added value of CEM in preoperative staging of breast cancer. Further evaluation in larger prospective randomized trials is needed.Trial registration: ClinicalTrials.gov., NCT03402529, Registered 18 January 2018 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03402529?term=NCT03402529&draw=2&rank=1

scholarly journals Added value of contrast-enhanced mammography (CEM) in staging of malignant breast lesions—a feasibility study

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Kristina Åhsberg ◽  
Anna Gardfjell ◽  
Emma Nimeus ◽  
Rogvi Rasmussen ◽  
Catharina Behmer ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Added Value ◽  
Breast Lesions ◽  
Contrast Enhanced ◽  
Malignant Breast

scholarly journals Magnetically Guided Localization Using a Guiding-Marker System® and a Handheld Magnetic Probe for Nonpalpable Breast Lesions: A Multicenter Feasibility Study in Japan

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2923
Author(s):  
Tomoko Kurita ◽  
Kanae Taruno ◽  
Seigo Nakamura ◽  
Hiroyuki Takei ◽  
Katsutoshi Enokido ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Safety Margin ◽  
Target Lesion ◽  
Magnetic Probe ◽  
Resected Specimen ◽  
Breast Lesions ◽  
Marker System ◽  
Magnetic Marker ◽  
Nonpalpable Lesions ◽  
Nonpalpable Breast Lesions

Accurate pre-operative localization of nonpalpable lesions plays a pivotal role in guiding breast-conserving surgery (BCS). In this multicenter feasibility study, nonpalpable breast lesions were localized using a handheld magnetic probe (TAKUMI) and a magnetic marker (Guiding-Marker System®). The magnetic marker was preoperatively placed within the target lesion under ultrasound or stereo-guidance. Additionally, a dye was injected subcutaneously to indicate the extent of the tumor excision. Surgeons checked for the marker within the lesion using a magnetic probe. The magnetic probe could detect the guiding marker and accurately localize the target lesion intraoperatively. All patients with breast cancer underwent wide excision with a safety margin of ≥5 mm. The presence of the guiding-marker within the resected specimen was the primary outcome and the pathological margin status and re-excision rate were the secondary outcomes. Eighty-seven patients with nonpalpable lesions who underwent BCS, from January to March of 2019 and from January to July of 2020, were recruited. The magnetic marker was detected in all resected specimens. The surgical margin was positive only in 5/82 (6.1%) patients; these patients underwent re-excision. This feasibility study demonstrated that the magnetic guiding localization system is useful for the detection and excision of nonpalpable breast lesions.

scholarly journals Can DWI-MRI be an alternative to DCE-MRI in the diagnosis of troublesome breast lesions?

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Lamiaa Mohamed Bassam Hashem ◽  
Sherihan W. Y. Gareer ◽  
Aya Mohamed Bassam Hashem ◽  
Sherihan Fakhry ◽  
Yasmin Mounir Tohamey
Keyword(s):  
Problem Solver ◽  
Breast Lesions ◽  
Diffusion Weighted Mri ◽  
Resonance Imaging ◽  
Contrast Administration ◽  
Dce Mri ◽  
Water Diffusivity ◽  
Contrast Enhanced ◽  
Mri Study ◽  
Established Technique

Abstract Background Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has always been a problem solver in troublesome breast lesions. Despite its many advantages, the encountered low specificity results in unnecessary biopsies. Diffusion-weighted MRI (DW-MRI) is a well-established technique that helps in characterizing breast lesions according to their water diffusivity. So this work aimed to assess the diagnostic performance of DW-MRI in troublesome breast lesions and see if it can replace DCE-MRI study. Results In our prospective study, we included 86 patients with mammography and/or ultrasound-detected 90 probably benign or probably malignant (BIRADS 3 or 4) breast lesions. Among the studied cases, 49/90 lesions were benign, and 41/90 were malignant. Combined analysis of morphological and kinetic findings in DCE-MRI had achieved the highest sensitivity of 95.1%. DW-MRI alone was less sensitive (73.2%) yet more specific (83.7%) than DCE-MRI (77.6%). Diagnostic accuracy of DCE-MRI was higher (85.6%) as compared to DW-MRI which was (78.9%). Conclusion DCE-MRI is the cornerstone in the workup of troublesome breast lesions. DW-MRI should not be used as supplementary tool unless contrast administration is contraindicated. Combining both DCE-MRI and DW-MRI is the ultimate technique for better lesion evaluation.

scholarly journals Contrast-enhanced ultrasound of breast fibromatosis: a case report

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110106
Author(s):  
Shanhong Lin ◽  
Yong Cao ◽  
Libin Chen ◽  
Mei Chen ◽  
Shengmin Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rare Case ◽  
Common Type ◽  
Breast Lesions ◽  
Contrast Enhanced Ultrasound ◽  
High Similarity ◽  
Potential Value ◽  
Contrast Enhanced ◽  
Malignant Breast ◽  
Contrast Enhanced Ultrasonography

We herein present a rare case of breast fibromatosis, the contrast-enhanced ultrasonography (CEUS) findings of which we believe have never been described. The high similarity between the clinical and imaging manifestations of breast cancer makes its differential diagnosis difficult. In this report, we describe the CEUS findings of a less common type of fibromatosis, discuss the potential value of CEUS to differentiate it from malignant breast lesions, and briefly review the literature.

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