Literature Review of Gastric Cancer Producing Alphafetoprotein

Author(s):  
Tsung SH
Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Bilal Alkhaffaf ◽  
Jane M. Blazeby ◽  
Aleksandra Metryka ◽  
Anne-Marie Glenny ◽  
Ademola Adeyeye ◽  
...  

Abstract Background Core outcome sets (COS) should be relevant to key stakeholders and widely applicable and usable. Ideally, they are developed for international use to allow optimal data synthesis from trials. Electronic Delphi surveys are commonly used to facilitate global participation; however, this has limitations. It is common for these surveys to be conducted in a single language potentially excluding those not fluent in that tongue. The aim of this study is to summarise current approaches for optimising international participation in Delphi studies and make recommendations for future practice. Methods A comprehensive literature review of current approaches to translating Delphi surveys for COS development was undertaken. A standardised methodology adapted from international guidance derived from 12 major sets of translation guidelines in the field of outcome reporting was developed. As a case study, this was applied to a COS project for surgical trials in gastric cancer to translate a Delphi survey into 7 target languages from regions active in gastric cancer research. Results Three hundred thirty-two abstracts were screened and four studies addressing COS development in rheumatoid and osteoarthritis, vascular malformations and polypharmacy were eligible for inclusion. There was wide variation in methodological approaches to translation, including the number of forward translations, the inclusion of back translation, the employment of cognitive debriefing and how discrepancies and disagreements were handled. Important considerations were identified during the development of the gastric cancer survey including establishing translation groups, timelines, understanding financial implications, strategies to maximise recruitment and regulatory approvals. The methodological approach to translating the Delphi surveys was easily reproducible by local collaborators and resulted in an additional 637 participants to the 315 recruited to complete the source language survey. Ninety-nine per cent of patients and 97% of healthcare professionals from non-English-speaking regions used translated surveys. Conclusion Consideration of the issues described will improve planning by other COS developers and can be used to widen international participation from both patients and healthcare professionals.


2015 ◽  
Vol 17 ◽  
pp. 34-40 ◽  
Author(s):  
Amilcare Parisi ◽  
Ninh T. Nguyen ◽  
Daniel Reim ◽  
Shu Zhang ◽  
Zhi-Wei Jiang ◽  
...  

2021 ◽  
Vol 19 (1) ◽  
pp. 34-40
Author(s):  
Lorena Chaparro-Diaz ◽  
Maria Zoraida Rojas ◽  
Sonia Patricia Carreño-Moreno

Background: Gastric (stomach) cancer is common, difficult to detect and has a high mortality rate. Many gastric cancers are treatable with invasive gastrointestinal surgery, including total or partial gastrectomy. These patients face many postoperative challenges, including pain, nausea and nutritional difficulties, as well as consequent anxiety and socio-economic challenges. Some healthcare institutions have implemented discharge plans as a cost-effective strategy to improve postoperative care. Aim: This systematic literature review aimed to identify essential elements to incorporate in the design and implementation of discharge plans for post-surgical gastric cancer patients. Methods: A systematic literature search was performed on the Cochrane Central Register of Controlled Studies, Elsevier Scopus and the library database of the National University of Colombia. These articles were assessed for relevance and underwent thematic analysis. Findings: The search returned nine relevant articles in English and Spanish. They suggested that discharge plans should start from first contact with a nurse and integrate the patient and their family and carers into the process of home self-care and recovery. These plans should also guide nurses to provide ongoing patient education, nutritional interventions and psychosocial support, as well as prevention of thromboembolism and assistance with symptom management and coming to terms with a new life situation. Conclusions: Discharge plans reduce the negative impact of the disease and invasive procedures on patients, families and health systems, reducing unplanned hospitalisation and readmission. There is a need to develop and test supportive care programmes that are designed to meet the needs of patients and focus on improving patients' quality of life after this life-changing surgery.


Author(s):  
Daisuke Gomi ◽  
Toshirou Fukushima ◽  
Takashi Kobayashi ◽  
Nodoka Sekiguchi ◽  
Akiyuki Sakamoto ◽  
...  

Author(s):  
Leandro Cardoso BARCHI ◽  
Marcus Fernando Kodama Pertille RAMOS ◽  
André Roncon DIAS ◽  
Nelson Adami ANDREOLLO ◽  
Antônio Carlos WESTON ◽  
...  

ABSTRACT Background: Since the publication of the first Brazilian Consensus on Gastric Cancer (GC) in 2012 carried out by the Brazilian Gastric Cancer Association, new concepts on diagnosis, staging, treatment and follow-up have been incorporated. Aim: This new consensus is to promote an update to professionals working in the fight against GC and to provide guidelines for the management of patients with this condition. Methods: Fifty-nine experts answered 67 statements regarding the diagnosis, staging, treatment and prognosis of GC with five possible alternatives: 1) fully agree; 2) partially agree; 3) undecided; 4) disagree and 5) strongly disagree A consensus was adopted when at least 80% of the sum of the answers “fully agree” and “partially agree” was reached. This article presents only the responses of the participating experts. Comments on each statement, as well as a literature review, will be presented in future publications. Results: Of the 67 statements, there was consensus in 50 (74%). In 10 declarations, there was 100% agreement. Conclusion: The gastric cancer treatment has evolved considerably in recent years. This consensus gathers consolidated principles in the last decades, new knowledge acquired recently, as well as promising perspectives on the management of this disease.


2019 ◽  
Vol 69 (1) ◽  
pp. 1-6
Author(s):  
Marek Krawczyk ◽  
Michał Skalski ◽  
Michał Grąt ◽  
Piotr Krawczyk ◽  
Oskar Kornasiewicz

2017 ◽  
Vol 119 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Audrius Dulskas ◽  
Mahdi Al Bandar ◽  
Yoon Young Choi ◽  
Su-Jin Shin ◽  
Seung-Hoon Beom ◽  
...  

2017 ◽  
Vol 3 (3) ◽  
pp. 101 ◽  
Author(s):  
Simona Gurzu ◽  
MariusAlexandru Beleaua ◽  
Laura Banias ◽  
Ioan Jung

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