scholarly journals Organophotoredox-Catalyzed Direct C-H Functionalization of “Drug Prejudice” at Room Temperature

2020 ◽  
Author(s):  
Narendra Chaubey ◽  
Anant Kapdi ◽  
Biswanath Maity
Keyword(s):  
Room Temperature ◽  
Bond Functionalization ◽  
First Report ◽  
Metal Free ◽  
Mild Conditions ◽  
The Past ◽  
Free Environment

<p>Organophotocatalytic C─H bond functionalization has attracted lot of attention in the past several years due to the possibility of catalysing reactions in a metal-free environment. Continuing on these lines, we repot herein an organophotoredox catalyzed C─H functionalization of imidazo[1,2-a]pyridines and related heterocycles with malonates under mild conditions providing excellent yields of the products at room temperature. Although, C─3 functionalization of imidazo[1,2-a]pyridines are known, this is the first report involving malonates as coupling partners leading to the synthesis of a range of functionalized products including Zolpidem, a sedative-hypnotic medicine. </p>

scholarly journals Organophotoredox-Catalyzed Direct C-H Functionalization of “Drug Prejudice” at Room Temperature

2020 ◽  
Author(s):  
Narendra Chaubey ◽  
Anant Kapdi ◽  
Biswanath Maity
Keyword(s):  
Room Temperature ◽  
Bond Functionalization ◽  
First Report ◽  
Metal Free ◽  
Mild Conditions ◽  
The Past ◽  
Free Environment

<p>Organophotocatalytic C─H bond functionalization has attracted lot of attention in the past several years due to the possibility of catalysing reactions in a metal-free environment. Continuing on these lines, we repot herein an organophotoredox catalyzed C─H functionalization of imidazo[1,2-a]pyridines and related heterocycles with malonates under mild conditions providing excellent yields of the products at room temperature. Although, C─3 functionalization of imidazo[1,2-a]pyridines are known, this is the first report involving malonates as coupling partners leading to the synthesis of a range of functionalized products including Zolpidem, a sedative-hypnotic medicine. </p>

scholarly journals Organophotoredox-Catalyzed Direct C-H Functionalization of “Drug Prejudice” at Room Temperature

2020 ◽  
Author(s):  
Narendra Chaubey ◽  
Anant Kapdi ◽  
Biswanath Maity
Keyword(s):  
Room Temperature ◽  
Bond Functionalization ◽  
First Report ◽  
Metal Free ◽  
Mild Conditions ◽  
The Past ◽  
Free Environment

<p>Organophotocatalytic C─H bond functionalization has attracted lot of attention in the past several years due to the possibility of catalysing reactions in a metal-free environment. Continuing on these lines, we repot herein an organophotoredox catalyzed C─H functionalization of imidazo[1,2-a]pyridines and related heterocycles with malonates under mild conditions providing excellent yields of the products at room temperature. Although, C─3 functionalization of imidazo[1,2-a]pyridines are known, this is the first report involving malonates as coupling partners leading to the synthesis of a range of functionalized products including Zolpidem, a sedative-hypnotic medicine. </p>

Organophotoredox-Catalyzed C–H Alkylation of Imidazoheterocycles with Malonates: Total Synthesis of Zolpidem

Synthesis ◽  
2020 ◽  
Author(s):  
Narendra R. Chaubey ◽  
Anant R. Kapdi ◽  
Biswanath Maity
Keyword(s):  
Total Synthesis ◽  
Room Temperature ◽  
Drug Molecule ◽  
Bond Functionalization ◽  
First Report ◽  
Mild Conditions ◽  
The Past ◽  
Hypnotic Drug ◽  
Free Environment

AbstractOrganophotocatalytic C–H bond functionalization has attracted a lot of attention in the past several years due to the possibility of catalyzing reactions in a metal- and peroxide-free environment. Continuing on these lines, an organophotoredox-catalyzed C–H functionalization of imidazo[1,2-a]pyridines and related heterocycles with bromomalonates under mild conditions is reported, providing excellent yields of the products at room temperature. This is the first report involving malonates as coupling partners leading to the synthesis of a range of functionalized products including total synthesis of zolpidem, a sedative­-hypnotic drug molecule.

Metal-free phosphonation of heteroarene N-oxides with trialkyl phosphite at room temperature

2017 ◽  
Vol 15 (15) ◽  
pp. 3165-3169 ◽  
Author(s):  
Ming-Tao Chen ◽  
Xia You ◽  
Li-Gang Bai ◽  
Qun-Li Luo
Keyword(s):  
Room Temperature ◽  
Trialkyl Phosphite ◽  
Metal Free ◽  
Mild Conditions ◽  
Short Time

Heteroarene N-oxides were successfully converted to heteroarylphosphonates in a very short time under mild conditions through in situ activation with CBrCl3.

Ultrasound accelerated expedient and eco-friendly synthesis of aryl sulfonates using I2 as catalyst at ambient conditions

2021 ◽  
Vol 18 ◽  
Author(s):  
Sha Zhu ◽  
Bin-Bin Wang ◽  
Mei-Chen Tan ◽  
Xiaofu Qian ◽  
Shengneng Ying ◽  
...  
Keyword(s):  
Energy Saving ◽  
Room Temperature ◽  
Coupling Reaction ◽  
Ambient Conditions ◽  
Metal Free ◽  
Mild Conditions ◽  
Efficient Construction ◽  
Ultrasound Assisted

: By using an energy-saving and eco-friendly approach for the efficient construction of aryl sulfonates through ultrasound-assisted coupling reaction of readily sodium sulfinates with N-hydroxyphthalimide was developed under metal-free and mild conditions within 10 min at room temperature.

scholarly journals Eosin Y-catalyzed visible-light-mediated aerobic oxidative cyclization of N,N-dimethylanilines with maleimides

2015 ◽  
Vol 11 ◽  
pp. 425-430 ◽  
Author(s):  
Zhongwei Liang ◽  
Song Xu ◽  
Wenyan Tian ◽  
Ronghua Zhang
Keyword(s):  
Visible Light ◽  
Oxidative Cyclization ◽  
Eosin Y ◽  
Efficient Synthesis ◽  
One Pot ◽  
Bond Functionalization ◽  
Metal Free ◽  
Mild Conditions ◽  
Simple Strategy ◽  
Air Atmosphere

A novel and simple strategy for the efficient synthesis of the corresponding tetrahydroquinolines from N,N-dimethylanilines and maleimides using visible light in an air atmosphere in the presence of Eosin Y as a photocatalyst has been developed. The metal-free protocol involves aerobic oxidative cyclization via sp3 C–H bond functionalization process to afford good yields in a one-pot procedure under mild conditions.

Metal-free photocatalytic aerobic oxidation of biomass-based furfural derivatives to prepare γ-butyrolactone

2021 ◽  
Author(s):  
Rui Zhu ◽  
Gongyu Zhou ◽  
Jia-nan Teng ◽  
Wanying Liang ◽  
Xinglong Li ◽  
...  
Keyword(s):  
Visible Light ◽  
Room Temperature ◽  
Aerobic Oxidation ◽  
Metal Free ◽  
Mild Conditions ◽  
Photocatalytic System

A heterogeneous metal-free photocatalytic system was developed for photocatalytic aerobic oxidation of biomass-based furfural derivatives to prepare γ-butyrolactone under mild conditions (visible light, room temperature, no base, and O2 balloon).

scholarly journals Diastereoselective synthesis of fused oxazolidines and highly substituted 1H-pyrrolo [2,1-c][1,4] oxazines via C–H functionalization

RSC Advances ◽  
2015 ◽  
Vol 5 (76) ◽  
pp. 61664-61670 ◽  
Author(s):  
Chottanahalli. S. Pavan Kumar ◽  
Kachigere. B. Harsha ◽  
Kempegowda Mantelingu ◽  
Kanchugarakoppal. S. Rangappa
Keyword(s):  
Benzoic Acid ◽  
Diastereoselective Synthesis ◽  
One Pot ◽  
Bond Functionalization ◽  
Metal Free ◽  
Mild Conditions ◽  
Acid Catalyzed ◽  
Catalyzed Reactions

The first one pot protocol for the diastereoselective synthesis of oxazolo[2,3-c]isoquinoline was achieved by metal-free, benzoic acid catalyzed reactions under mild conditions via C–H, C–O bond functionalization.

Metal-free insertion of sulfur dioxide with aryl iodides under ultraviolet irradiation: direct access to sulfonated cyclic compounds

2020 ◽  
Vol 7 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Shengqing Ye ◽  
Kaida Zhou ◽  
Pornchai Rojsitthisak ◽  
Jie Wu
Keyword(s):  
Sulfur Dioxide ◽  
Ultraviolet Irradiation ◽  
Room Temperature ◽  
Direct Access ◽  
Metal Free ◽  
Mild Conditions ◽  
Aryl Iodides ◽  
Convenient Route ◽  
Cyclic Compounds ◽  
Allylic Bromide

Metal-free insertion of sulfur dioxide with aryl iodides and silyl enolates or allylic bromide under ultraviolet irradiation at room temperature is accomplished. This protocol provides a convenient route to sulfonated cyclic compounds under mild conditions.

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