Ultrasound accelerated expedient and eco-friendly synthesis of aryl sulfonates using I2 as catalyst at ambient conditions

2021 ◽  
Vol 18 ◽  
Author(s):  
Sha Zhu ◽  
Bin-Bin Wang ◽  
Mei-Chen Tan ◽  
Xiaofu Qian ◽  
Shengneng Ying ◽  
...  
Keyword(s):  
Energy Saving ◽  
Room Temperature ◽  
Coupling Reaction ◽  
Ambient Conditions ◽  
Metal Free ◽  
Mild Conditions ◽  
Efficient Construction ◽  
Ultrasound Assisted

: By using an energy-saving and eco-friendly approach for the efficient construction of aryl sulfonates through ultrasound-assisted coupling reaction of readily sodium sulfinates with N-hydroxyphthalimide was developed under metal-free and mild conditions within 10 min at room temperature.

scholarly journals A New Heterogeneous Catalyst Obtained via Supramolecular Decoration of Graphene with a Pd2+ Azamacrocyclic Complex

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2714 ◽  
Author(s):  
Matteo Savastano ◽  
Paloma Arranz-Mascarós ◽  
Maria Paz Clares ◽  
Rafael Cuesta ◽  
Maria Luz Godino-Salido ◽  
...  
Keyword(s):  
Heterogeneous Catalyst ◽  
Self Assembly ◽  
Room Temperature ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Assembly Process ◽  
Efficient Catalyst ◽  
Mild Conditions ◽  
Cross Coupling Reaction ◽  
Green Procedure

A new G-(H2L)-Pd heterogeneous catalyst has been prepared via a self-assembly process consisting in the spontaneous adsorption, in water at room temperature, of a macrocyclic H2L ligand on graphene (G) (G + H2L = G-(H2L)), followed by decoration of the macrocycle with Pd2+ ions (G-(H2L) + Pd2+ = G-(H2L)-Pd) under the same mild conditions. This supramolecular approach is a sustainable (green) procedure that preserves the special characteristics of graphene and furnishes an efficient catalyst for the Cu-free Sonogashira cross coupling reaction between iodobenzene and phenylacetylene. Indeed, G-(H2L)-Pd shows an excellent conversion (90%) of reactants into diphenylacetylene under mild conditions (50 °C, water, aerobic atmosphere, 14 h). The catalyst proved to be reusable for at least four cycles, although decreasing yields down to 50% were observed.

Metal-free phosphonation of heteroarene N-oxides with trialkyl phosphite at room temperature

2017 ◽  
Vol 15 (15) ◽  
pp. 3165-3169 ◽  
Author(s):  
Ming-Tao Chen ◽  
Xia You ◽  
Li-Gang Bai ◽  
Qun-Li Luo
Keyword(s):  
Room Temperature ◽  
Trialkyl Phosphite ◽  
Metal Free ◽  
Mild Conditions ◽  
Short Time

Heteroarene N-oxides were successfully converted to heteroarylphosphonates in a very short time under mild conditions through in situ activation with CBrCl3.

Nitrogen enriched polytriazine as a metal-free heterogeneous catalyst for the Knoevenagel reaction under mild conditions

2018 ◽  
Vol 42 (15) ◽  
pp. 12924-12928 ◽  
Author(s):  
Monika Chaudhary ◽  
Paritosh Mohanty
Keyword(s):  
Heterogeneous Catalyst ◽  
Knoevenagel Reaction ◽  
Ambient Conditions ◽  
Metal Free ◽  
Mild Conditions

A nitrogen-enriched nanoporous polytriazine was used as a metal-free heterogeneous organocatalyst for high-yielding ultra-fast Knoevenagel reactions under ambient conditions.

scholarly journals Organophotoredox-Catalyzed Direct C-H Functionalization of “Drug Prejudice” at Room Temperature

2020 ◽  
Author(s):  
Narendra Chaubey ◽  
Anant Kapdi ◽  
Biswanath Maity
Keyword(s):  
Room Temperature ◽  
Bond Functionalization ◽  
First Report ◽  
Metal Free ◽  
Mild Conditions ◽  
The Past ◽  
Free Environment

<p>Organophotocatalytic C─H bond functionalization has attracted lot of attention in the past several years due to the possibility of catalysing reactions in a metal-free environment. Continuing on these lines, we repot herein an organophotoredox catalyzed C─H functionalization of imidazo[1,2-a]pyridines and related heterocycles with malonates under mild conditions providing excellent yields of the products at room temperature. Although, C─3 functionalization of imidazo[1,2-a]pyridines are known, this is the first report involving malonates as coupling partners leading to the synthesis of a range of functionalized products including Zolpidem, a sedative-hypnotic medicine. </p>

An Iodide-Mediated Transition-Metal-Free Strategy towards Unsymmetrical Diaryl Sulfides via Arylhydrazines and Thiols

Synthesis ◽  
2019 ◽  
Vol 52 (05) ◽  
pp. 727-734 ◽  
Author(s):  
Farnaz Jafarpour ◽  
Mohammad Asadpour ◽  
Meysam Azizzade ◽  
Mehran Ghasemi ◽  
Saideh Rajai-Daryasarei
Keyword(s):  
Transition Metal ◽  
Room Temperature ◽  
Bond Formation ◽  
Antidepressant Drug ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Potential Utility ◽  
Metal Free ◽  
Cross Coupling Reaction ◽  
High Yields

A mild, scalable iodine-mediated oxidative cross-coupling reaction of arylhydrazines and thiols for construction of thioethers (sulfides) in the absence of any transition metals or photocatalysts is disclosed. A variety of unsymmetrical diaryl sulfides with broad substrate scope both on thiols and hydrazines were synthesized in high yields in water at room temperature. Furthermore, to demonstrate the utility of the protocol, the above C–S bond formation was applied in the synthesis of the key structure of vortioxetine as an antidepressant drug. The gram-scale outcome also added to the potential utility of this protocol.

scholarly journals One-Pot, Metal-Free Synthesis of Dimethyl Carbonate from CO2 at Room Temperature

2020 ◽  
Vol 1 (3) ◽  
pp. 298-314
Author(s):  
Santosh Govind Khokarale ◽  
Thai Q. Bui ◽  
Jyri-Pekka Mikkola
Keyword(s):  
Ionic Liquid ◽  
Room Temperature ◽  
Dimethyl Carbonate ◽  
High Selectivity ◽  
Chemical Species ◽  
Side Reactions ◽  
Ambient Conditions ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free

Herein, we report on the metal-free, one-pot synthesis of industrially important dimethyl carbonate (DMC) from molecular CO2 under ambient conditions. In this process, initially the CO2 was chemisorbed through the formation of a switchable ionic liquid (SIL), [DBUH] [CH3CO3], by the interaction of CO2 with an equivalent mixture of organic superbase 1,8-diazabicyclo-[5.4.0]-undec-7-ene (DBU) and methanol. The obtained SIL further reacted with methyl iodide (CH3I) to form DMC. The synthesis was carried out in both dimethyl sulfoxide (DMSO) and methanol. Methanol is preferred, as it not only served as a reagent and solvent in CO2 capture and DMC synthesis, but it also assisted in controlling the side reactions between chemical species such as CH3I and [DBUH]+ cation and increased the yield of DMC. Hence, the use of methanol avoided the loss of captured CO2 and favored the formation of DMC with high selectivity. Under the applied reaction conditions, 89% of the captured CO2 was converted to DMC. DBU was obtained, achieving 86% recovery of its salts formed during the synthesis. Most importantly, in this report we describe a simple and renewable solvent-based process for a metal-free approach to DMC synthesis under industrially feasible reaction conditions.

An N-heterocyclic carbene-functionalised covalent organic framework with atomically dispersed palladium for coupling reactions under mild conditions

2019 ◽  
Vol 21 (19) ◽  
pp. 5267-5273 ◽  
Author(s):  
Junjuan Yang ◽  
Yuanyuan Wu ◽  
Xiaowei Wu ◽  
Wenjing Liu ◽  
Yaofang Wang ◽  
...  
Keyword(s):  
Room Temperature ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Pure Ethanol ◽  
Covalent Organic Framework ◽  
Mild Conditions ◽  
Cross Coupling Reaction ◽  
Aqueous Solvent ◽  
Organic Framework

We report a heterogeneous catalyst based on N-heterocyclic carbene-functionalized covalent organic framework, which shows high activity in the C–C cross coupling reaction at room temperature in pure/ethanol aqueous solvent even with multiple reuse.

Synthesis of Multibromo-Substituted Quinolines by NBS-Mediated Cascade Electrophilic Bromination/Cyclization of N-(3-Phenylprop-2-ynyl)anilines

Synthesis ◽  
2021 ◽  
Author(s):  
Ruchun Yang ◽  
Qiang Xiao ◽  
Si Deng ◽  
Wenliang Ouyang ◽  
Jiang Bai ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Sonogashira Coupling ◽  
Metal Free ◽  
Cascade Cyclization ◽  
Mild Conditions ◽  
Free Process ◽  
Substituted Quinolines ◽  
Sonogashira Coupling Reaction ◽  
Electrophilic Bromination

AbstractA new and convenient protocol is presented here for the synthesis of 3,6,8-tribromoquinolines via cascade cyclization of N-(3-phenylprop-2-ynyl)anilines employing N-bromosuccinimide as an electrophile. The metal-free process is carried out under mild conditions and is compatible with a variety of substituents. The Sonogashira coupling reaction regioselectively occurs at position C-6 of the obtained products.

ChemInform Abstract: Metal-Free Direct Construction of Sulfonamides via Iodine-Mediated Coupling Reaction of Sodium Sulfinates and Amines at Room Temperature.

ChemInform ◽  
2015 ◽  
Vol 46 (30) ◽  
pp. no-no
Author(s):  
Wei Wei ◽  
ChunLi Liu ◽  
Daoshan Yang ◽  
Jiangwei Wen ◽  
Jinmao You ◽  
...  
Keyword(s):  
Room Temperature ◽  
Coupling Reaction ◽  
Direct Construction ◽  
Metal Free

Pd–Co nanoalloys nested on CuO nanosheets for efficient electrocatalytic N2 reduction and room-temperature Suzuki–Miyaura coupling reaction

Nanoscale ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 1379-1385 ◽  
Author(s):  
Wenzhi Fu ◽  
Yudong Cao ◽  
Qianyi Feng ◽  
William R. Smith ◽  
Pei Dong ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Room Temperature ◽  
Coupling Reaction ◽  
Coupling Reactions ◽  
Ambient Conditions ◽  
Cuo Nanosheets

The nanoalloy structure greatly improves the catalytic activity for electrocatalytic N2 reduction and Suzuki–Miyaura coupling reactions under ambient conditions.

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