A Di Copper Peptidyl Complex Mimics Catalase Activity in HeLa HyPer Cells
Keyword(s):
In this manuscript, we describe the implementation of a combinatorial apporach to synthesize a library of copper complexes, associated with an activity-based screening to discover the first peptidyl di copper complex mimicking CAT redox chemistry. The selected dinuclear complex was studied in detail and characterized for its CAT activity i<i>n vitro</i> and in cells. Very interestingly, despite moderate intrinsic catalysis constant, this complex was efficacious in a cellular assay.<br>
2018 ◽
Vol 2018
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pp. 3144-3144
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pp. 1227-1232
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Vol 91
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pp. 292-299
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pp. 239-242
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Vol 9
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pp. 300-303
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