scholarly journals A Di Copper Peptidyl Complex Mimics Catalase Activity in HeLa HyPer Cells

2020 ◽  
Author(s):  
Koudedja Coulibaly ◽  
Marion Thauvin ◽  
Adyn Melenbacher ◽  
Clara testard ◽  
Evangelia Trigoni ◽  
...  
Keyword(s):  
Copper Complex ◽  
Catalase Activity ◽  
Copper Complexes ◽  
Redox Chemistry ◽  
Dinuclear Complex ◽  
Cellular Assay ◽  
In Cells

In this manuscript, we describe the implementation of a combinatorial apporach to synthesize a library of copper complexes, associated with an activity-based screening to discover the first peptidyl di copper complex mimicking CAT redox chemistry. The selected dinuclear complex was studied in detail and characterized for its CAT activity i<i>n vitro</i> and in cells. Very interestingly, despite moderate intrinsic catalysis constant, this complex was efficacious in a cellular assay.<br>

scholarly journals A Di Copper Peptidyl Complex Mimics Catalase Activity in HeLa HyPer Cells

2020 ◽  
Author(s):  
Koudedja Coulibaly ◽  
Marion Thauvin ◽  
Adyn Melenbacher ◽  
Clara testard ◽  
Evangelia Trigoni ◽  
...  
Keyword(s):  
Copper Complex ◽  
Catalase Activity ◽  
Copper Complexes ◽  
Redox Chemistry ◽  
Dinuclear Complex ◽  
Cellular Assay ◽  
In Cells

In this manuscript, we describe the implementation of a combinatorial apporach to synthesize a library of copper complexes, associated with an activity-based screening to discover the first peptidyl di copper complex mimicking CAT redox chemistry. The selected dinuclear complex was studied in detail and characterized for its CAT activity i<i>n vitro</i> and in cells. Very interestingly, despite moderate intrinsic catalysis constant, this complex was efficacious in a cellular assay.<br>

Controlled nitrene transfer from a tyrosinase-like arylnitroso–copper complex

2015 ◽  
Vol 51 (56) ◽  
pp. 11206-11209 ◽  
Author(s):  
Mohammad S. Askari ◽  
Maylis Orio ◽  
Xavier Ottenwaelder
Keyword(s):  
Electronic Structure ◽  
Copper Complex ◽  
Dinuclear Complex ◽  
Nitrene Transfer

The reaction between p-nitrosonitrobenzene and the tetramethylpropylenediamine–copper(i) complex yields a dinuclear complex that has similar topology, electronic structure and reactivity as side-on peroxo species known in Cu/O2 chemistry.

Oxidation of copper(II) hydroxyporphyrin (oxophlorin); oxidative ring opening and formation of an ester-linked, dinuclear copper complex

2001 ◽  
Vol 79 (5-6) ◽  
pp. 922-929 ◽  
Author(s):  
Shane Phillips ◽  
Bruce C Noll ◽  
Marilyn M Olmstead ◽  
Alan L Balch
Keyword(s):  
Crystal Structure ◽  
Copper Complex ◽  
Epr Spectroscopy ◽  
Ring Opening ◽  
Oxidative Cleavage ◽  
Dinuclear Complex ◽  
Dinuclear Copper ◽  
Ring Opening Reaction ◽  
Copper Porphyrin ◽  
Ester Linkage

Addition of copper(II) acetate to octaethyl(meso-hydroxy)porphyrin (H2OEPOH) in THF under a dinitrogen atmosphere produces CuII(OEPOH), which has been isolated as red crystals and shown to have a meso-hydroxyporphyrin structure by UV-vis and EPR spectroscopy. CuII(OEPOH) undergoes oxidation by dioxygen to form a novel dinuclear copper complex {CuII(OEPOC(O)OEB)CuII}. This dinuclear complex is composed of a copper(II) meso-substituted porphyrin portion (with a planar CuN4 unit), which is attached through an ester linkage to a helical copper(II) tetrapyrrole that has been ring-opened through oxidative cleavage of a second molecule of CuII(OEPOH). The oxidative ring-opening reaction resembles that of natural heme catabolism but is arrested at a stage where the oxidized meso-carbon is still appended to the helical open tetrapyrrole. A mechanism is suggested for this process.Key words: copper porphyrin, crystal structure, porphyrin oxidation, linear tetrapyrrole, hydroxy-porphyrin, oxophlorin.

Catalytic activity of dithioic acid copper complexes in the alkyne–azide cycloaddition

2013 ◽  
Vol 91 (4) ◽  
pp. 292-299 ◽  
Author(s):  
Bayardo E. Velasco ◽  
Gustavo López-Téllez ◽  
Nelly González-Rivas ◽  
Iván García-Orozco ◽  
Erick Cuevas-Yañez
Keyword(s):  
Catalytic Activity ◽  
Copper Complex ◽  
Copper Complexes ◽  
Functional Group ◽  
High Efficiency ◽  
High Catalytic Activity ◽  
Different Temperatures ◽  
High Yields

Diverse dithioic acid copper complexes exhibit a high catalytic activity in the copper-catalyzed alkyne–azide cycloaddition using several solvents under different temperatures, showing a high efficiency with only 0.005 mmol catalyst/mmol alkyne or less. A dithioic acid copper complex derived from acetophenone was selected and used as the catalyst in the preparation of a library of 1,4-disubstituted-1,2,3-triazoles. This process occurred in high yields and good functional group tolerance.

scholarly journals A Proteomic View of Cellular Responses to Anticancer Quinoline-Copper Complexes

Proteomes ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 26 ◽  
Author(s):  
Bastien Dalzon ◽  
Joanna Bons ◽  
Hélène Diemer ◽  
Véronique Collin-Faure ◽  
Caroline Marie-Desvergne ◽  
...  
Keyword(s):  
Copper Complex ◽  
Copper Complexes ◽  
Leukemic Cell ◽  
Anticancer Activities ◽  
Proteomic Approach ◽  
Target Action ◽  
Biological Target ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway ◽  
Validation Experiments

Metal-containing drugs have long been used in anticancer therapies. The mechansims of action of platinum-based drugs are now well-understood, which cannot be said of drugs containing other metals, such as gold or copper. To gain further insights into such mechanisms, we used a classical proteomic approach based on two-dimensional elelctrophoresis to investigate the mechanisms of action of a hydroxyquinoline-copper complex, which shows promising anticancer activities, using the leukemic cell line RAW264.7 as the biological target. Pathway analysis of the modulated proteins highlighted changes in the ubiquitin/proteasome pathway, the mitochondrion, the cell adhesion-cytoskeleton pathway, and carbon metabolism or oxido-reduction. In line with these prteomic-derived hypotheses, targeted validation experiments showed that the hydroxyquinoline-copper complex induces a massive reduction in free glutathione and a strong alteration in the actin cytoskeleton, suggesting a multi-target action of the hydroxyquinoline-copper complex on cancer cells.

scholarly journals Salicylaldehyde thiosemicarbazone copper complexes: impact of hybridization with estrone on cytotoxicity, solution stability and redox activity

2020 ◽  
Vol 44 (28) ◽  
pp. 12154-12168
Author(s):  
Tatsiana V. Petrasheuskaya ◽  
Márton A. Kiss ◽  
Orsolya Dömötör ◽  
Tamás Holczbauer ◽  
Nóra V. May ◽  
...  
Keyword(s):  
Copper Complex ◽  
Copper Complexes ◽  
Redox Activity ◽  
Solution Stability

Copper complex of a novel estrone–thiosemicarbazone hybrid with significant cytotoxicity, lipophilicity and solution stability in addition to its structurally related bicyclic analogue.

scholarly journals Synthesis and crystal structure of the dinuclear copper(II) Schiff base complex μ-hydroxido-μ-chlorido-bis{[bis(trans-2-nitrocinnamaldehyde)ethylenediamine]chloridocopper(II)} dichloromethane sesquisolvate

2016 ◽  
Vol 72 (3) ◽  
pp. 239-242
Author(s):  
Kazem Barati ◽  
William Clegg ◽  
Mohammad Hossein Habibi ◽  
Ross W. Harrington ◽  
Arash Lalegani ◽  
...  
Keyword(s):  
Schiff Base ◽  
Copper Complexes ◽  
Schiff Base Complex ◽  
Dinuclear Complex ◽  
Molar Ratio ◽  
Schiff Base Ligands ◽  
Synthesis And Crystal Structure ◽  
Trigonal Bipyramidal ◽  
Solvent Molecules ◽  
Hydroxide Bridge

Transition metal complexes of Schiff base ligands have been shown to have particular application in catalysis and magnetism. The chemistry of copper complexes is of interest owing to their importance in biological and industrial processes. The reaction of copper(I) chloride with the bidentate Schiff baseN,N′-bis(trans-2-nitrocinnamaldehyde)ethylenediamine {Nca2en, systematic name: (1E,1′E,2E,2′E)-N,N′-(ethane-1,2-diyl)bis[3-(2-nitrophenyl)prop-2-en-1-imine]} in a 1:1 molar ratio in dichloromethane without exclusion of air or moisture resulted in the formation of the title complex μ-chlorido-μ-hydroxido-bis(chlorido{(1E,1′E,2E,2′E)-N,N′-(ethane-1,2-diyl)bis[3-(2-nitrophenyl)prop-2-en-1-imine]-κ2N,N′}copper(II)) dichloromethane sesquisolvate, [Cu2Cl3(OH)(C20H18N4O4)2]·1.5CH2Cl2. The dinuclear complex has a folded four-membered ring in an unsymmetrical Cu2OCl3core in which the approximate trigonal bipyramidal coordination displays different angular distortions in the equatorial planes of the two CuIIatoms; the chloride bridge is asymmetric, but the hydroxide bridge is symmetric. The chelate rings of the two Nca2en ligands have different conformations, leading to a more marked bowing of one of the ligands compared with the other. This is the first reported dinuclear complex, and the first five-coordinate complex, of the Nca2en Schiff base ligand. Molecules of the dimer are associated in pairs by ring-stacking interactions supported by C—H...Cl interactions with solvent molecules; a further ring-stacking interaction exists between the two Schiff base ligands of each molecule.

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